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Literature summary extracted from

  • Chu, F.F.; Doroshow, J.H.; Esworthy, R.S.
    Expression, characterization, and tissue distribution of a new cellular selenium-dependent glutathione peroxidase, GSHPx-GI (1993), J. Biol. Chem., 268, 2571-2576.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.11.1.9 expression in MCF-7c1 cells Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.11.1.9 cytosol
-
 Homo sapiens 5829
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.11.1.9 selenium selenocysteine Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.9 cumene hydroperoxide + GSH Homo sapiens
-
 ?
-
 ?
1.11.1.9 glutathione + ROOH Homo sapiens
-
 glutathione disulfide + ROH + H2O
-
 ?
1.11.1.9 H2O2 + GSH Homo sapiens
-
 H2O + GSSG
-
 ?
1.11.1.9 linolenic acid hydroperoxide + GSH Homo sapiens
-
 ?
-
 ?
1.11.1.9 tert-butyl hydroperoxide + 2 GSH Homo sapiens
-
 tert-butyl alcohol + GSSG + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.9 Homo sapiens
-
 Hep-G2 cells
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.1.9 liver
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.9 cumene hydroperoxide + GSH
-
 Homo sapiens ?
-
 ?
1.11.1.9 glutathione + ROOH
-
 Homo sapiens glutathione disulfide + ROH + H2O
-
 ?
1.11.1.9 H2O2 + GSH
-
 Homo sapiens H2O + GSSG
-
 ?
1.11.1.9 linolenic acid hydroperoxide + GSH
-
 Homo sapiens ?
-
 ?
1.11.1.9 tert-butyl hydroperoxide + 2 GSH
-
 Homo sapiens tert-butyl alcohol + GSSG + H2O
-
 ?

Subunits

EC Number Subunits Comment Organism
1.11.1.9 homotetramer alpha4, 4 * 22000-23000, SDS-PAGE Homo sapiens