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Literature summary extracted from

  • Tan, M.; Li, S.; Swaroop, M.; Guan, K.; Oberley, L.W.; Sun, Y.
    Transcriptional activation of the human glutathione peroxidase promoter by p53 (1999), J. Biol. Chem., 274, 12061-12066.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.11.1.9 etoposide activates p53, wich induces the expression of glutathione peroxidase Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.9 glutathione + ROOH Homo sapiens
-
 glutathione disulfide + ROH + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.9 Homo sapiens
-
 Saos-2 cell line
-
1.11.1.9 Homo sapiens
-
 U2-OS cell line
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.11.1.9 5
-
 Saos-2 Homo sapiens
1.11.1.9 5.5
-
 Saos-2 treated with etoposide Homo sapiens
1.11.1.9 6.7
-
 U2-OS Homo sapiens
1.11.1.9 11.9
-
 U2-OS treated with etoposide Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.9 glutathione + ROOH
-
 Homo sapiens glutathione disulfide + ROH + H2O
-
 ?