Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Hutzler, J.; Dancis, J.
    Saccharopine cleavage by a dehydrogenase of human liver (1970), Biochim. Biophys. Acta, 206, 205-214.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.1.9 hydroxylamine slight Homo sapiens
1.5.1.9 NH4Cl slight Homo sapiens
1.5.1.9 p-hydroxymercuribenzoate
-
Homo sapiens
1.5.1.9 Sodium bisulfite slight Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.1.9 0.4
-
NAD+
-
Homo sapiens
1.5.1.9 0.5
-
saccharopine
-
Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.5.1.9 Cu2+ strong inhibition Homo sapiens
1.5.1.9 Hg2+ strong inhibition Homo sapiens
1.5.1.9 Zn2+ strong inhibition Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O Homo sapiens involved in lysine catabolism L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
r

Organism

EC Number Organism UniProt Comment Textmining
1.5.1.9 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.1.9
-
Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.1.9 liver
-
Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.5.1.9 additional information
-
-
Homo sapiens

Storage Stability

EC Number Storage Stability Organism
1.5.1.9 -20°C, crude enzyme stable for several months, purified enzyme inactivated within 3 weeks Homo sapiens
1.5.1.9 2°C, 5-10% loss of activity per week, purified enzyme Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine, high specificity Homo sapiens L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
r
1.5.1.9 N6-(L-1,3-dicarboxypropyl)-L-lysine + NAD+ + H2O involved in lysine catabolism Homo sapiens L-glutamate + 2-aminoadipate 6-semialdehyde + NADH + H+
-
r

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.5.1.9 30
-
-
Homo sapiens

Temperature Range [°C]

EC Number Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
1.5.1.9 20 37 20°C: 35% of activity maximum, 37°C: 85% of activity maximum Homo sapiens

Temperature Stability [°C]

EC Number Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
1.5.1.9 37
-
5 min Homo sapiens
1.5.1.9 44
-
5 min, 50% activity Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.1.9 8.8 9
-
Homo sapiens

pH Range

EC Number pH Minimum pH Maximum Comment Organism
1.5.1.9 7.8 9.7 half maximal activities at pH 7.8 and 9.7 Homo sapiens

pH Stability

EC Number pH Stability pH Stability Maximum Comment Organism
1.5.1.9 6.6 9.9 10 min Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.1.9 NAD+
-
Homo sapiens
1.5.1.9 NADP+ 20fold higher activity with NAD+ than NAPD+ Homo sapiens