EC Number | Cloned (Comment) | Organism |
---|---|---|
1.3.1.22 | monkey SR type 1 cDNA expression in CHO-cells | Macaca fascicularis |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.22 | 4-methyl-4-azasteroids | competitive | Homo sapiens | |
1.3.1.22 | 4-methyl-4-azasteroids | competitive | Macaca fascicularis | |
1.3.1.22 | 4-methyl-4-azasteroids | competitive | Rattus norvegicus | |
1.3.1.22 | 4-methyl-azasteroid | - |
Homo sapiens | |
1.3.1.22 | 4-methyl-azasteroid | - |
Macaca fascicularis | |
1.3.1.22 | 4-methyl-azasteroid | - |
Rattus norvegicus | |
1.3.1.22 | acrylate episteride | - |
Homo sapiens | |
1.3.1.22 | acrylate episteride | - |
Macaca fascicularis | |
1.3.1.22 | acrylate episteride | - |
Rattus norvegicus | |
1.3.1.22 | finasteride | - |
Homo sapiens | |
1.3.1.22 | finasteride | - |
Macaca fascicularis | |
1.3.1.22 | finasteride | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.1.22 | 0.0002 | - |
testosterone | isoenzyme 2 | Macaca fascicularis | |
1.3.1.22 | 0.0002 | - |
progesterone | isoenzyme 2 | Macaca fascicularis | |
1.3.1.22 | 0.0002 | - |
20alpha-hydroxyprogesterone | isoenzyme 1 | Homo sapiens | |
1.3.1.22 | 0.0003 | - |
progesterone | isoenzyme 2 | Homo sapiens | |
1.3.1.22 | 0.0003 | - |
progesterone | isoenzyme 1 | Homo sapiens | |
1.3.1.22 | 0.0003 | - |
progesterone | isoenzyme 1 | Macaca fascicularis | |
1.3.1.22 | 0.0004 | - |
androstenedione | isoenzyme 2 | Macaca fascicularis | |
1.3.1.22 | 0.0004 | - |
20alpha-hydroxyprogesterone | isoenzyme 2 | Homo sapiens | |
1.3.1.22 | 0.0005 | - |
20alpha-hydroxyprogesterone | isoenzyme 1 | Macaca fascicularis | |
1.3.1.22 | 0.0006 | - |
androstenedione | isoenzyme 1 | Macaca fascicularis | |
1.3.1.22 | 0.0007 | - |
testosterone | isoenzyme 2 | Homo sapiens | |
1.3.1.22 | 0.0008 | - |
androstenedione | isoenzyme 2 | Homo sapiens | |
1.3.1.22 | 0.001 | - |
androstenedione | isoenzyme 1 | Homo sapiens | |
1.3.1.22 | 0.002 | - |
corticosterone | isoenzyme 2 | Macaca fascicularis | |
1.3.1.22 | 0.002 | - |
testosterone | isoenzyme 1 | Macaca fascicularis | |
1.3.1.22 | 0.0035 | - |
testosterone | isoenzyme 1 | Homo sapiens | |
1.3.1.22 | 0.004 | - |
corticosterone | isoenzyme 2 | Homo sapiens | |
1.3.1.22 | 0.008 | - |
corticosterone | isoenzyme 1 | Macaca fascicularis | |
1.3.1.22 | 0.018 | - |
corticosterone | isoenzyme 1 | Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.22 | Homo sapiens | - |
- |
- |
1.3.1.22 | Macaca fascicularis | - |
- |
- |
1.3.1.22 | Rattus norvegicus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.3.1.22 | prostate gland | - |
Homo sapiens | - |
1.3.1.22 | prostate gland | - |
Rattus norvegicus | - |
1.3.1.22 | prostate gland | - |
Macaca fascicularis | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.22 | 20-alpha-hydroxypregn-4-ene-3one + NADPH | - |
Homo sapiens | 20-alpha-hydroxy-5alpha-pregnan-3-one + NADP+ | - |
? | |
1.3.1.22 | 20-alpha-hydroxypregn-4-ene-3one + NADPH | - |
Macaca fascicularis | 20-alpha-hydroxy-5alpha-pregnan-3-one + NADP+ | - |
? | |
1.3.1.22 | androstenedione + NADPH + H+ | - |
Homo sapiens | 5alpha-androstan-3,17-dione + NADP+ | - |
? | |
1.3.1.22 | androstenedione + NADPH + H+ | - |
Rattus norvegicus | 5alpha-androstan-3,17-dione + NADP+ | - |
? | |
1.3.1.22 | androstenedione + NADPH + H+ | - |
Macaca fascicularis | 5alpha-androstan-3,17-dione + NADP+ | - |
? | |
1.3.1.22 | corticosterone + NADPH + H+ | - |
Homo sapiens | 5alpha-dihydrocorticosterone + NADP+ | - |
r | |
1.3.1.22 | corticosterone + NADPH + H+ | - |
Macaca fascicularis | 5alpha-dihydrocorticosterone + NADP+ | - |
r | |
1.3.1.22 | deoxycorticosterone + NADPH | - |
Homo sapiens | 21-hydroxy-5alpha-pregnan-3,20-dione | - |
? | |
1.3.1.22 | deoxycorticosterone + NADPH | - |
Rattus norvegicus | 21-hydroxy-5alpha-pregnan-3,20-dione | - |
? | |
1.3.1.22 | deoxycorticosterone + NADPH | - |
Macaca fascicularis | 21-hydroxy-5alpha-pregnan-3,20-dione | - |
? | |
1.3.1.22 | progesterone + NADPH + H+ | - |
Homo sapiens | 5alpha-pregnan-3,20-dione + NADP+ | - |
? | |
1.3.1.22 | progesterone + NADPH + H+ | - |
Rattus norvegicus | 5alpha-pregnan-3,20-dione + NADP+ | - |
? | |
1.3.1.22 | progesterone + NADPH + H+ | - |
Macaca fascicularis | 5alpha-pregnan-3,20-dione + NADP+ | - |
? | |
1.3.1.22 | testosterone + NADPH + H+ | - |
Homo sapiens | 17beta-hydroxy-5alpha-androstan-3-one + NADP+ | - |
? | |
1.3.1.22 | testosterone + NADPH + H+ | - |
Rattus norvegicus | 17beta-hydroxy-5alpha-androstan-3-one + NADP+ | - |
? | |
1.3.1.22 | testosterone + NADPH + H+ | - |
Macaca fascicularis | 17beta-hydroxy-5alpha-androstan-3-one + NADP+ | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.3.1.22 | 5 | - |
recombinant monkey 5alpha-reductase isozyme 2 | Macaca fascicularis |
1.3.1.22 | 5 | - |
recombinant human 5alpha-reductase isozyme 2 | Homo sapiens |
1.3.1.22 | 7.5 | - |
recombinant human 5alpha-reductase isozyme 1 | Homo sapiens |
1.3.1.22 | 8 | - |
recombinant monkey 5alpha-reductase isozyme 1 | Macaca fascicularis |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.3.1.22 | 4.5 | 9.5 | recombinant human 5alpha-reductase isozyme 2 | Homo sapiens |
1.3.1.22 | 4.5 | 7.5 | recombinant monkey 5alpha-reductase isozyme 2 | Macaca fascicularis |
1.3.1.22 | 4.5 | 9 | recombinant human 5alpha-reductase isozyme 1 | Homo sapiens |
1.3.1.22 | 5.5 | 9 | recombinant monkey 5alpha-reductase isozyme 1 | Macaca fascicularis |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.1.22 | 0.0000003 | - |
acylate episteride | iosenzyme 2 | Homo sapiens | |
1.3.1.22 | 0.0000005 | - |
acylate episteride | iosenzyme 2 | Macaca fascicularis | |
1.3.1.22 | 0.000001 | - |
finasteride | iosenzyme 2 | Homo sapiens | |
1.3.1.22 | 0.000002 | - |
4-methyl-azasteroid | iosenzyme 2 | Macaca fascicularis | |
1.3.1.22 | 0.000003 | - |
4-methyl-azasteroid | iosenzyme 1 | Homo sapiens | |
1.3.1.22 | 0.000003 | - |
4-methyl-azasteroid | iosenzyme 1 | Macaca fascicularis | |
1.3.1.22 | 0.000003 | - |
4-methyl-azasteroid | iosenzyme 2 | Rattus norvegicus | |
1.3.1.22 | 0.000004 | - |
finasteride | iosenzyme 2 | Rattus norvegicus | |
1.3.1.22 | 0.000004 | - |
4-methyl-azasteroid | iosenzyme 2 | Homo sapiens | |
1.3.1.22 | 0.000004 | - |
acylate episteride | iosenzyme 2 | Rattus norvegicus | |
1.3.1.22 | 0.000005 | - |
finasteride | iosenzyme 2 | Macaca fascicularis | |
1.3.1.22 | 0.000006 | - |
finasteride | iosenzyme 1 | Rattus norvegicus | |
1.3.1.22 | 0.000008 | - |
4-methyl-azasteroid | iosenzyme 1 | Rattus norvegicus | |
1.3.1.22 | 0.00002 | - |
acylate episteride | iosenzyme 1 | Rattus norvegicus | |
1.3.1.22 | 0.00022 | - |
finasteride | iosenzyme 1 | Macaca fascicularis | |
1.3.1.22 | 0.0005 | - |
acylate episteride | iosenzyme 1 | Macaca fascicularis | |
1.3.1.22 | 0.001 | - |
finasteride | iosenzyme 1 | Homo sapiens | |
1.3.1.22 | 0.0041 | - |
acylate episteride | iosenzyme 1 | Homo sapiens |