EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.3.1.22 | alpha-4-azasteroids | substitution of finasteride N-group by 6-azasteroids increased the rate of inhibition of type-1 5-alpha-reductases | Homo sapiens | |
1.3.1.22 | finasteride | 17-beta-N-tert-butylcarbonyl-4-aza-5alpha-androstan-1-en-3-one is a time-dependent, apparently irreversible inhibitor of 5alpha-reductases, but does not fully inhibit the activity of 5alpha-reductase in vivo | Homo sapiens |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.1.22 | 0.00069 | - |
progesterone | - |
Homo sapiens | |
1.3.1.22 | 0.0063 | - |
testosterone | - |
Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.3.1.22 | microsome | - |
Homo sapiens | - |
- |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.3.1.22 | Homo sapiens | - |
- |
- |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.3.1.22 | progesterone + NADPH + H+ | - |
Homo sapiens | 5alpha-pregnan-3,20-dione + NADP+ | - |
? |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.3.1.22 | 0.00036 | - |
finasteride | - |
Homo sapiens |