Literature summary extracted from

Voigt, W.; Hsia, S.I.
Further studies on testosterone 5 -reductase of human skin. Structural features of steroid inhibitors (1973), J. Biol. Chem., 248, 4280-4285.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.3.1.22	4-Androsten-3-one-17beta-carboxylic acid	competitive	Homo sapiens
1.3.1.22	deoxycorticosterone acetate	competitive	Homo sapiens
1.3.1.22	additional information	-	Homo sapiens
1.3.1.22	progesterone	competitive	Homo sapiens

Localization

EC Number	Localization	Comment	Organism	GeneOntology No.	Textmining
1.3.1.22	microsome	-	Homo sapiens	-	-

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.3.1.22	Homo sapiens	-	-	-

Source Tissue

EC Number	Source Tissue	Comment	Organism	Textmining
1.3.1.22	skin	-	Homo sapiens	-

Substrates and Products (Substrate)

EC Number	Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
1.3.1.22	cholest-4-en-3-one + NADPH	-	Homo sapiens	5-alpha-cholestan-3-one + NADP+	-	?

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.3.1.22	NADPH	-	Homo sapiens

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Release 2023.1 (January 2023)