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Literature summary extracted from

  • Graef, V.; Golf, S.W.; Tuschen, M.
    NADPH: 4-ene-3-oxosteroid-5alpha-reductase and NADH: 4-ene-3-oxosteroid-5alpha-reductase in liver microsomes of different species of animals (1981), J. Steroid Biochem., 14, 883-887.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.3.1.22 microsome
-
 Gallus gallus
-
-
1.3.1.22 microsome
-
 Mus musculus
-
-
1.3.1.22 microsome
-
 Homo sapiens
-
-
1.3.1.22 microsome
-
 Rattus norvegicus
-
-
1.3.1.22 microsome
-
 Sus scrofa
-
-
1.3.1.22 microsome
-
 Oryctolagus cuniculus
-
-
1.3.1.22 microsome
-
 Mesocricetus auratus
-
-
1.3.1.22 microsome
-
 Chinchilla chinchilla
-
-

Organism

EC Number Organism UniProt Comment Textmining
1.3.1.22 Chinchilla chinchilla
-
-
-
1.3.1.22 Gallus gallus
-
-
-
1.3.1.22 Homo sapiens
-
-
-
1.3.1.22 Mesocricetus auratus
-
 golden Hamster
-
1.3.1.22 Mus musculus
-
-
-
1.3.1.22 Oryctolagus cuniculus
-
-
-
1.3.1.22 Rattus norvegicus
-
-
-
1.3.1.22 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.3.1.22 liver
-
 Gallus gallus
-
1.3.1.22 liver
-
 Mus musculus
-
1.3.1.22 liver
-
 Homo sapiens
-
1.3.1.22 liver
-
 Rattus norvegicus
-
1.3.1.22 liver
-
 Sus scrofa
-
1.3.1.22 liver
-
 Oryctolagus cuniculus
-
1.3.1.22 liver
-
 Mesocricetus auratus
-
1.3.1.22 liver
-
 Chinchilla chinchilla
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.3.1.22 0.00148
-
 female Mesocricetus auratus
1.3.1.22 0.00234
-
 male Mesocricetus auratus
1.3.1.22 0.03413
-
 female Rattus norvegicus
1.3.1.22 1090
-
 male Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.3.1.22 cholest-4-en-3-one + NADPH
-
 Gallus gallus 5-alpha-cholestan-3-one + NADP+
-
 ?
1.3.1.22 cholest-4-en-3-one + NADPH
-
 Mus musculus 5-alpha-cholestan-3-one + NADP+
-
 ?
1.3.1.22 cholest-4-en-3-one + NADPH
-
 Homo sapiens 5-alpha-cholestan-3-one + NADP+
-
 ?
1.3.1.22 cholest-4-en-3-one + NADPH
-
 Rattus norvegicus 5-alpha-cholestan-3-one + NADP+
-
 ?
1.3.1.22 cholest-4-en-3-one + NADPH
-
 Sus scrofa 5-alpha-cholestan-3-one + NADP+
-
 ?
1.3.1.22 cholest-4-en-3-one + NADPH
-
 Oryctolagus cuniculus 5-alpha-cholestan-3-one + NADP+
-
 ?
1.3.1.22 cholest-4-en-3-one + NADPH
-
 Mesocricetus auratus 5-alpha-cholestan-3-one + NADP+
-
 ?
1.3.1.22 cholest-4-en-3-one + NADPH
-
 Chinchilla chinchilla 5-alpha-cholestan-3-one + NADP+
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.3.1.22 6.2
-
 female Homo sapiens
1.3.1.22 7
-
 male Mesocricetus auratus
1.3.1.22 7.2
-
 male Rattus norvegicus
1.3.1.22 7.2
-
 male Chinchilla chinchilla

Cofactor

EC Number Cofactor Comment Organism Structure
1.3.1.22 NADPH
-
 Gallus gallus
1.3.1.22 NADPH
-
 Mus musculus
1.3.1.22 NADPH
-
 Homo sapiens
1.3.1.22 NADPH
-
 Rattus norvegicus
1.3.1.22 NADPH
-
 Sus scrofa
1.3.1.22 NADPH
-
 Oryctolagus cuniculus
1.3.1.22 NADPH
-
 Mesocricetus auratus
1.3.1.22 NADPH
-
 Chinchilla chinchilla