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Literature summary extracted from

  • Blatt, J.M.; Pledger, W.J.; Umbarger, H.E.
    Isoleucine and valine metabolism in Escherichia coli. XX. Multiple forms of acetohydroxy acid synthetase (1972), Biochem. Biophys. Res. Commun., 48, 444-450.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.2.1.6 Ile isoenzyme AHS I is sensitive to feed-back inhibition, isoenzyme AHS II is insensitive Escherichia coli
2.2.1.6 Leu isoenzyme AHS I is sensitive to feed-back inhibition, isoenzyme AHS II is insensitive Escherichia coli
2.2.1.6 Val isoenzyme AHS I is sensitive to feed-back inhibition, isoenzyme AHS II is insensitive Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
2.2.1.6 pyruvate Escherichia coli production of isoenzyme AHS I is under multivalent control by Val and Leu, production of isoenzyme AHS II is under multivalent control by Ile, Val and Leu ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.6 Escherichia coli
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 2 enzyme form AHS I and AHS II
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.2.1.6 pyruvate
-
 Escherichia coli 2-acetolactate + CO2
-
 ?
2.2.1.6 pyruvate production of isoenzyme AHS I is under multivalent control by Val and Leu, production of isoenzyme AHS II is under multivalent control by Ile, Val and Leu Escherichia coli ?
-
 ?