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Literature summary extracted from

  • Xing, R.; Whitman, W.B.
    Sulfometuron methyl-sensitive and -resistant acetolactate synthases of the archaebacteria Methanococcus spp. (1987), J. Bacteriol., 169, 4486-4492.
    View publication on PubMedView publication on EuropePMC

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.2.1.6 Ile no inhibition Methanococcus aeolicus
2.2.1.6 Ile
-
 Methanococcus maripaludis
2.2.1.6 Ile
-
 Methanococcus voltae
2.2.1.6 Leu no inhibition Methanococcus aeolicus
2.2.1.6 Leu
-
 Methanococcus maripaludis
2.2.1.6 Leu no inhibition Methanococcus voltae
2.2.1.6 Val feed-back inhibition Methanococcus aeolicus
2.2.1.6 Val feed-back inhibition Methanococcus maripaludis
2.2.1.6 Val feed-back inhibition Methanococcus voltae

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
2.2.1.6 0.5
-
 pyruvate
-
 Methanococcus voltae
2.2.1.6 2.3
-
 pyruvate
-
 Methanococcus aeolicus
2.2.1.6 4.2
-
 pyruvate
-
 Methanococcus maripaludis

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.2.1.6 Mg2+ strong requirement Methanococcus aeolicus

Organism

EC Number Organism UniProt Comment Textmining
2.2.1.6 Methanococcus aeolicus
-
-
-
2.2.1.6 Methanococcus maripaludis
-
-
-
2.2.1.6 Methanococcus voltae
-
-
-
2.2.1.6 Methanothermococcus thermolithotrophicus
-
-
-

Oxidation Stability

EC Number Oxidation Stability Organism
2.2.1.6 10% O2, 37°C, 30 min, 90% loss of activity Methanococcus aeolicus
2.2.1.6 10% O2, 37°C, 30 min, 90% loss of activity Methanococcus maripaludis

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
2.2.1.6 pyruvate
-
 Methanothermococcus thermolithotrophicus 2-acetolactate + CO2
-
 ?
2.2.1.6 pyruvate
-
 Methanococcus aeolicus 2-acetolactate + CO2
-
 ?
2.2.1.6 pyruvate
-
 Methanococcus maripaludis 2-acetolactate + CO2
-
 ?
2.2.1.6 pyruvate
-
 Methanococcus voltae 2-acetolactate + CO2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
2.2.1.6 FAD
-
 Methanococcus aeolicus
2.2.1.6 thiamine diphosphate required as cofactor Methanothermococcus thermolithotrophicus
2.2.1.6 thiamine diphosphate required as cofactor Methanococcus aeolicus
2.2.1.6 thiamine diphosphate required as cofactor Methanococcus maripaludis
2.2.1.6 thiamine diphosphate required as cofactor Methanococcus voltae
2.2.1.6 thiamine diphosphate required after dialysis Methanococcus aeolicus
2.2.1.6 thiamine diphosphate required after dialysis Methanococcus maripaludis
2.2.1.6 thiamine diphosphate required after dialysis Methanococcus voltae
2.2.1.6 thiamine diphosphate Km: 0.0033 mM Methanococcus maripaludis
2.2.1.6 thiamine diphosphate Km: 0.0031 mM Methanococcus voltae