Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Rueffer, M.; Zenk, M.H.
    Berberine synthase, the methylenedioxy group forming enzyme in berberine synthesis (1985), Tetrahedron Lett., 26, 201-202.
No PubMed abstract available

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.21.3.2 1,10-phenanthroline
-
 Berberis stolonifera
1.21.3.2 cyanide
-
 Berberis stolonifera
1.21.3.2 p-phenanthroline
-
 Berberis stolonifera

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.21.3.2 0.002
-
 Columbamine
-
 Berberis stolonifera

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.21.3.2 Fe2+ an iron protein, oxidation of the O-methoxyphenol structure forms the methylenedioxy group of berberine, Fe2+ restores activity after dialysis against o-phenanthroline Berberis stolonifera

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.21.3.2 columbamine + O2 Berberis stolonifera berberine biosynthesis ?
-
 ir

Organism

EC Number Organism UniProt Comment Textmining
1.21.3.2 Berberis stolonifera
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.21.3.2
-
 Berberis stolonifera

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.21.3.2 columbamine + O2
-
 Berberis stolonifera berberine + H2O
-
 ir
1.21.3.2 columbamine + O2 berberine biosynthesis Berberis stolonifera ?
-
 ir
1.21.3.2 additional information
-
 Berberis stolonifera ?
-
 ?

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.21.3.2 70
-
-
 Berberis stolonifera

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.21.3.2 8.9
-
-
 Berberis stolonifera