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Literature summary extracted from

  • Boeckmann, B.; Bairoch, A.; Apweiler, R.; Blatter, M.C.; Estreicher, A.; Gasteiger, E.; Martin M.J.; Michoud, K.; O'Donovan, C.; Phan, I.; Pilbout, S.; Schneider, M.
    The SWISS-PROT protein knowledgebase and its supplement TrEMBL (2003), Nucleic Acids Res., 31, 365-370.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
3.4.21.34 factor XIIa activation by cleavage into light- and heavy-chain, that are linked by one or more disulfide bridges after cleavage Homo sapiens
3.4.21.34 factor XIIa activation by cleavage into light- and heavy-chain, that are linked by one or more disulfide bridges after cleavage Rattus norvegicus
3.4.21.34 factor XIIa activation by cleavage into light- and heavy-chain, that are linked by one or more disulfide bridges after cleavage Mus musculus
3.4.21.34 additional information binding to negatively charged surfaces activates the enzyme Homo sapiens
3.4.21.34 additional information binding to negatively charged surfaces activates the enzyme Rattus norvegicus
3.4.21.34 additional information binding to negatively charged surfaces activates the enzyme Mus musculus

Cloned(Commentary)

EC Number Cloned (Comment) Organism
3.4.22.B25
-
 Rattus norvegicus
3.4.22.54 cloning of human full-length CDSs in BD Creator(TM) system donor vector Homo sapiens
3.4.22.54 skeletal muscle enzyme Sus scrofa

Inhibitors

EC Number Inhibitors Comment Organism Structure
3.4.22.54 calpastatin
-
 Bos taurus
3.4.22.54 calpastatin
-
 Homo sapiens
3.4.22.54 calpastatin
-
 Mus musculus
3.4.22.54 calpastatin
-
 Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
3.4.21.34 soluble plasma Homo sapiens
-
-
3.4.21.34 soluble plasma Rattus norvegicus
-
-
3.4.21.34 soluble plasma Mus musculus
-
-
3.4.22.B24 cytoplasm translocates to the plasma membrane upon Ca2+ binding Bos taurus 5737
-
3.4.22.B24 cytoplasm translocates to the plasma membrane upon Ca2+ binding Mus musculus 5737
-
3.4.22.B24 cytoplasm translocates to the plasma membrane upon Ca2+ binding Sus scrofa 5737
-
3.4.22.B24 cytoplasm translocates to the plasma membrane upon Ca2+ binding Homo sapiens 5737
-
3.4.22.B24 cytoplasm translocates to the plasma membrane upon Ca2+ binding Rattus norvegicus 5737
-
3.4.22.B27 nucleus
-
 Homo sapiens 5634
-
3.4.22.B27 nucleus
-
 Mus musculus 5634
-
3.4.22.54 cytoplasm
-
 Sus scrofa 5737
-
3.4.22.54 cytoplasm
-
 Homo sapiens 5737
-
3.4.22.54 cytoplasm
-
 Bos taurus 5737
-
3.4.22.54 cytoplasm
-
 Mus musculus 5737
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.7.11.17 Ca2+ Ca2+/calmodulin-dependent Homo sapiens
2.7.11.17 Ca2+ Ca2+/calmodulin-dependent Mus musculus
2.7.11.17 Ca2+ Ca2+/calmodulin-dependent Metarhizium anisopliae
3.4.22.B24 Ca2+ the enzyme contains 4 EF-hand calcium-binding domains Bos taurus
3.4.22.B24 Ca2+ the enzyme contains 4 EF-hand calcium-binding domains Mus musculus
3.4.22.B24 Ca2+ the enzyme contains 4 EF-hand calcium-binding domains Sus scrofa
3.4.22.B24 Ca2+ the enzyme contains 4 EF-hand calcium-binding domains Homo sapiens
3.4.22.B24 Ca2+ the enzyme contains 4 EF-hand calcium-binding domains Rattus norvegicus
3.4.22.B29 Ca2+ regulates the enzyme, contains 2 EF-hand calcium-binding domains Rattus norvegicus
3.4.22.B29 Ca2+ regulates the enzyme, contains 2 EF-hand calcium-binding domains Mus musculus
3.4.22.B29 Ca2+ regulates the enzyme, contains 2 EF-hand calcium-binding domains Homo sapiens
3.4.22.B30 Ca2+ calcium-regulated protein Mus musculus
3.4.22.B30 Ca2+ calcium-regulated protein Homo sapiens
3.4.22.B30 Ca2+ calcium-regulated protein Macaca fascicularis
3.4.22.B30 Ca2+ calcium-regulated protein Rattus norvegicus
3.4.22.B31 Ca2+ contains 2 EF-hand calcium-binding domains Homo sapiens
3.4.22.B32 Ca2+ calcium-regulated thiol protease Mus musculus
3.4.22.54 Ca2+ regulated by Ca2+, contains 2 EF-hand calcium-binding domains. Activated by micromolar concentrations of calcium Sus scrofa
3.4.22.54 Ca2+ regulated by Ca2+, contains 2 EF-hand calcium-binding domains. Activated by micromolar concentrations of calcium Homo sapiens
3.4.22.54 Ca2+ regulated by Ca2+, contains 2 EF-hand calcium-binding domains. Activated by micromolar concentrations of calcium Bos taurus
3.4.22.54 Ca2+ regulated by Ca2+, contains 2 EF-hand calcium-binding domains. Activated by micromolar concentrations of calcium Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
3.4.21.34 factor XII + H2O Homo sapiens activation of the factor XII, bound to negatively charged surfaces ?
-
 ir
3.4.21.34 factor XII + H2O Rattus norvegicus activation of the factor XII, bound to negatively charged surfaces ?
-
 ir
3.4.21.34 factor XII + H2O Mus musculus activation of the factor XII, bound to negatively charged surfaces ?
-
 ir
3.4.21.34 kininogen + H2O Homo sapiens high-molecular weight kininogen bradykinin + fragments of kininogen
-
 ir
3.4.21.34 kininogen + H2O Rattus norvegicus high-molecular weight kininogen bradykinin + fragments of kininogen
-
 ir
3.4.21.34 kininogen + H2O Mus musculus high-molecular weight kininogen bradykinin + fragments of kininogen
-
 ir
3.4.21.34 additional information Homo sapiens defects in gene KLKB1 cause Fletcher factor deficiency, a blood coagulation defect ?
-
 ?
3.4.21.34 Prorenin + H2O Homo sapiens activation of prorenin, involved in the renin-angiotensin system Renin + ?
-
 ir
3.4.21.34 Prorenin + H2O Rattus norvegicus activation of prorenin, involved in the renin-angiotensin system Renin + ?
-
 ir
3.4.21.34 Prorenin + H2O Mus musculus activation of prorenin, involved in the renin-angiotensin system Renin + ?
-
 ir
3.4.21.35 polypeptide + H2O Homo sapiens
-
 peptides
-
 ?
3.4.22.B24 additional information Bos taurus limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction ?
-
 ?
3.4.22.B24 additional information Mus musculus limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction ?
-
 ?
3.4.22.B24 additional information Sus scrofa limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction ?
-
 ?
3.4.22.B24 additional information Homo sapiens limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction ?
-
 ?
3.4.22.B24 additional information Rattus norvegicus limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction ?
-
 ?
3.4.22.B30 peptide + H2O Homo sapiens
-
 hydrolyzed peptide
-
 ?
3.4.22.B30 peptide + H2O Macaca fascicularis
-
 hydrolyzed peptide
-
 ?
3.4.22.B30 peptide + H2O Rattus norvegicus
-
 hydrolyzed peptide
-
 ?
3.4.22.B30 peptide + H2O Mus musculus proteolysis of substrates involved in cytoskeletal remodelling and signal transduction hydrolyzed peptide
-
 ?
3.4.22.B30 peptide + H2O Mus musculus 129/SvJ proteolysis of substrates involved in cytoskeletal remodelling and signal transduction hydrolyzed peptide
-
 ?
3.4.22.B31 peptide + H2O Homo sapiens the enzyme catalyzes limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction hydrolyzed peptide
-
 ?
3.4.24.B3 protein + H2O Homo sapiens
-
 peptides
-
 ?
3.4.24.B3 protein + H2O Xenopus laevis
-
 peptides
-
 ?
3.4.24.B4 protein + H2O Bos taurus
-
 peptides
-
 ?
3.4.24.B4 protein + H2O Rattus norvegicus
-
 peptides
-
 ?
3.4.24.B4 protein + H2O Xenopus laevis
-
 peptides
-
 ?
3.4.24.B4 protein + H2O Equus caballus
-
 peptides
-
 ?
3.4.24.B5 protein + H2O Homo sapiens
-
 peptides
-
 ?
3.4.24.B5 protein + H2O Mus musculus
-
 peptides
-
 ?
3.4.24.B6 proteins + H2O Mus musculus
-
 peptides
-
 ?
3.4.24.B6 proteins + H2O Sus scrofa
-
 peptides
-
 ?
3.4.24.B8 proteins + H2O Mus musculus
-
 peptides
-
 ?
3.4.24.B8 proteins + H2O Rattus norvegicus
-
 peptides
-
 ?
3.4.24.B9 proteins + H2O Homo sapiens
-
 peptides
-
 ?
3.4.24.B9 proteins + H2O Mus musculus
-
 peptides
-
 ?
3.4.24.B11 proteins + H2O Mus musculus
-
 peptides
-
 ?
3.4.24.B11 proteins + H2O Rattus norvegicus
-
 peptides
-
 ?
3.4.24.B12 proteins + H2O Homo sapiens
-
 peptides
-
 ?
3.4.24.B12 proteins + H2O Mus musculus
-
 peptides
-
 ?
3.4.24.B12 proteins + H2O Bos taurus
-
 peptides
-
 ?
3.4.24.B14 protein + H2O Mus musculus
-
 peptides
-
 ?
3.4.24.B15 protein + H2O Homo sapiens
-
 peptides
-
 ?
3.4.24.B15 protein + H2O Mus musculus
-
 peptides
-
 ?
3.4.24.B18 protein + H2O Saccharomyces cerevisiae
-
 peptides
-
 ?
3.4.24.B19 proteins + H2O Saccharomyces cerevisiae
-
 peptides
-
 ?
3.4.24.B20 proteins + H2O Arabidopsis thaliana
-
 peptides
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Mus musculus P48776 definite classification as EC 1.13.11.11 based on protein sequence
-
2.7.10.1 Caenorhabditis elegans Q10656
-
-
2.7.10.1 Drosophila melanogaster P04412
-
-
2.7.10.1 Gallus gallus Q91044
-
-
2.7.10.1 Gallus gallus Q91987
-
-
2.7.10.1 Homo sapiens P00533
-
-
2.7.10.1 Homo sapiens P04629
-
-
2.7.10.1 Homo sapiens P06213
-
-
2.7.10.1 Homo sapiens P07949
-
-
2.7.10.1 Homo sapiens P17948
-
-
2.7.10.1 Homo sapiens Q9UM73
-
-
2.7.10.1 Rattus norvegicus O08775
-
-
2.7.10.2 Danio rerio O12990
-
-
2.7.10.2 Danio rerio O93596
-
-
2.7.10.2 Drosophila melanogaster P00528
-
-
2.7.10.2 Drosophila melanogaster P18106
-
-
2.7.10.2 Drosophila melanogaster Q24145
-
-
2.7.10.2 Drosophila melanogaster Q9V9J3
-
-
2.7.10.2 Homo sapiens P06239
-
-
2.7.10.2 Homo sapiens Q06187
-
-
2.7.10.2 Macaca fascicularis Q95M30
-
-
2.7.10.2 Mus musculus P00520
-
-
2.7.10.2 Mus musculus Q9R117
-
-
2.7.10.2 Rattus norvegicus Q9WUD9
-
-
2.7.11.1 Homo sapiens O15530
-
-
2.7.11.1 Schizosaccharomyces pombe Q12701
-
-
2.7.11.7 Dictyostelium discoideum P34125 gene MHCK, myosin heavy chain kinase
-
2.7.11.7 Dictyostelium discoideum P42527 gene MHKA or MHCKA, myosin heavy chain kinase A
-
2.7.11.7 Dictyostelium discoideum P90648 gene MHKB or MHCKB, myosin heavy chain kinase B
-
2.7.11.11 Mus musculus P05132
-
-
2.7.11.17 Homo sapiens Q13554
-
-
2.7.11.17 Homo sapiens Q9UQM7
-
-
2.7.11.17 Metarhizium anisopliae O14408
-
-
2.7.11.17 Mus musculus Q923T9
-
-
2.7.11.18 Homo sapiens Q15746
-
-
3.4.21.B10 Homo sapiens Q92876 gene KLK6 or PRSS9
-
3.4.21.B10 Mus musculus P15947 gene KLK6, glandular kallikrein K6 precursor
-
3.4.21.B12 Homo sapiens Q9Y5K2 kallikrein 4 precursor
-
3.4.21.34 Homo sapiens P03952 gene KLK3 or KLKB1, plasma kallikrein precursor
-
3.4.21.34 Mus musculus P26262 gene KLKB1 or KLK3 or PK, plasma kallikrein precursor
-
3.4.21.34 Rattus norvegicus P14272 gene KLKB1 or PK, plasma kallikrein precursor
-
3.4.21.35 Homo sapiens P06870 glandular kallikrein 1 precursor
-
3.4.21.35 Macaca fascicularis Q07276 gene KLK1, glandular kallikrein 1 precursor
-
3.4.21.35 Mastomys natalensis P32824 gene KLK1, renal glanduar kallikrein precursor
-
3.4.21.35 Mastomys natalensis P32824 african soft-furred rat
-
3.4.21.35 Mus musculus P00755 gene KLK1, glandular kallikrein 1 precursor
-
3.4.21.35 Papio hamadryas Q28773 gene KLK1, glandular kallikrein 1 precursor
-
3.4.21.35 Rattus norvegicus P00758 gene KLK1, pancreatic glandular kallikrein 1 precursor
-
3.4.21.B39 Homo sapiens Q9Y337 gene KLK5 or SCTE
-
3.4.21.B39 Mus musculus P15945 glandular kallikrein K5 precursor
-
3.4.21.B40 Homo sapiens Q9UKQ9 precursor
-
3.4.21.B40 Homo sapiens Q9UKQ9 gene KLK-L3 or KLK9
-
3.4.21.B40 Mus musculus P15949 gene KLK9, glandula kallikrein K9 precursor
-
3.4.21.B40 Rattus norvegicus P07647 gene KLK9, submandibular glandular kallikrein 9 precursor
-
3.4.21.B41 Homo sapiens O43240 gene KLK10 or PRRSL or NES1
-
3.4.21.B42 Mus musculus P15946 gene KLK11, glandular kallkrein K11 precursor
-
3.4.21.B43 Homo sapiens Q9UKR0
-
-
3.4.21.B45 Homo sapiens Q9P0G3 gene KLK14 or KLK-L6
-
3.4.21.77 Homo sapiens P07288 enzyme precursor
-
3.4.21.77 Homo sapiens P07288 gene KLK3 or APS
-
3.4.21.77 Macaca mulatta P33619 gene KLK3 or APS
-
3.4.21.77 Macaca mulatta P33619 enzyme presursor
-
3.4.21.77 Macaca mulatta P33619 rhesus macaque
-
3.4.21.77 Mus musculus P00756 gene KLK3 or NGFG
-
3.4.21.77 Mus musculus P00756 glandular kallikrein K3 precursor
-
3.4.21.77 Rattus norvegicus P15950 gene KLK3
-
3.4.21.77 Rattus norvegicus P15950 glandular kallikrein 3 fragment
-
3.4.21.117 Homo sapiens P49862
-
-
3.4.21.118 Homo sapiens O60259 precursor
-
3.4.21.118 Homo sapiens O60259 TADG14
-
3.4.21.118 Homo sapiens O60259 gene KLK8 or PRSS19 or NRPN
-
3.4.21.118 Mus musculus P07628 gene KLK8
-
3.4.21.118 Mus musculus P07628 glandular kallikrein K8 precursor
-
3.4.21.118 Mus musculus Q61955 neuropsin precursor
-
3.4.21.118 Mus musculus Q61955 gene KLK8 or PRSS19 or NRPN or BSP1
-
3.4.21.118 Rattus norvegicus O88780 neuropsin precursor
-
3.4.21.118 Rattus norvegicus O88780 gene KLK8 or PRSS19 or NRPN or BSP1
-
3.4.21.118 Rattus norvegicus P36374 gene KLK8
-
3.4.21.118 Rattus norvegicus P36374 prostatic glandular kallikrein 8 precursor
-
3.4.21.119 Mus musculus P36368 gene KLK13 or EGFB2, glandular kallikrein K13 precursor
-
3.4.22.B1 Vigna mungo P12412
-
-
3.4.22.B24 Bos taurus P13135
-
-
3.4.22.B24 Homo sapiens P04632
-
-
3.4.22.B24 Mus musculus O88456
-
-
3.4.22.B24 Rattus norvegicus Q64537
-
-
3.4.22.B24 Sus scrofa P04574
-
-
3.4.22.B25 Mus musculus O08688
-
-
3.4.22.B25 Rattus norvegicus Q8R4C0
-
-
3.4.22.B25 Rattus norvegicus Sprague-Dawley Q8R4C0
-
-
3.4.22.B27 Homo sapiens Q7Z479
-
-
3.4.22.B27 Homo sapiens Q9Y6W3
-
-
3.4.22.B27 Mus musculus Q9R1S8
-
-
3.4.22.B29 Homo sapiens O14815
-
-
3.4.22.B29 Mus musculus Q9D805
-
-
3.4.22.B29 Mus musculus C57/BL6J Q9D805
-
-
3.4.22.B29 Rattus norvegicus O35920
-
-
3.4.22.B30 Homo sapiens Q9HC96
-
-
3.4.22.B30 Macaca fascicularis Q95LP4
-
-
3.4.22.B30 Mus musculus Q9ESK3
-
-
3.4.22.B30 Mus musculus 129/SvJ Q9ESK3
-
-
3.4.22.B30 Rattus norvegicus Q9ES66
-
-
3.4.22.B31 Homo sapiens Q9UMQ6
-
-
3.4.22.B32 Mus musculus Q9ER56
-
-
3.4.22.B35 Drosophila melanogaster P27398
-
-
3.4.22.B37 Drosophila melanogaster Q9VT65
-
-
3.4.22.B38 Drosophila melanogaster Q9VXH6
-
-
3.4.22.54 Bos taurus P51186
-
-
3.4.22.54 Homo sapiens P20807 alternative splicing: I: isoform ID P20807-1, this is the isoform sequence displayed in this entry. II: isoform IDP20807-2, features which should be applied to build the isoform sequence: VSP_005227, VSP_005228. III: isoform ID P20807-3, features which should be applied to build the isoform sequence: VSP_005229. IV: isoform ID P20807-4, features which should be applied to build the isoform sequence: VSP_007813
-
3.4.22.54 Mus musculus Q64691
-
-
3.4.22.54 Sus scrofa P43368
-
-
3.4.24.B3 Homo sapiens P24347 precursor
-
3.4.24.B3 Xenopus laevis Q11005 precursor
-
3.4.24.B4 Bos taurus O77656 precursor
-
3.4.24.B4 Equus caballus O18927 precursor
-
3.4.24.B4 Rattus norvegicus P23097 precursor fragment
-
3.4.24.B4 Xenopus laevis Q10835 precursor fragment
-
3.4.24.B5 Homo sapiens P51511 precursor
-
3.4.24.B5 Mus musculus O54732 precursor
-
3.4.24.B6 Mus musculus P57748 precursor
-
3.4.24.B6 Sus scrofa P79287 precursor
-
3.4.24.B8 Mus musculus Q60813 precursor
-
3.4.24.B8 Mus musculus Q8R534 precursor
-
3.4.24.B8 Rattus norvegicus P70505 precursor
-
3.4.24.B9 Homo sapiens Q13443
-
-
3.4.24.B9 Mus musculus Q61072
-
-
3.4.24.B11 Mus musculus P97857 precursor
-
3.4.24.B11 Rattus norvegicus Q9WUQ1
-
-
3.4.24.B12 Bos taurus Q9TT92 fragment
-
3.4.24.B12 Homo sapiens Q9UNA0 precursor
-
3.4.24.B12 Mus musculus Q9R001 precursor
-
3.4.24.B14 Mus musculus Q9JLI3
-
-
3.4.24.B15 Homo sapiens P78562
-
-
3.4.24.B15 Mus musculus P70669
-
-
3.4.24.B18 Saccharomyces cerevisiae P40341
-
-
3.4.24.B19 Saccharomyces cerevisiae P32795
-
-
3.4.24.B20 Arabidopsis thaliana O80860
-
-
3.4.24.86 Cricetulus griseus Q923X3 chinese hamster, fragment
-
3.4.24.86 Rattus norvegicus Q9Z1K9
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
3.4.21.B39 proteolytic cleavage of polypeptides enzyme is a serine protease Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
3.4.21.34 plasma
-
 Homo sapiens
-
3.4.21.34 plasma
-
 Rattus norvegicus
-
3.4.21.34 plasma
-
 Mus musculus
-
3.4.21.77 submandibular gland
-
 Rattus norvegicus
-
3.4.22.B27 brain
-
 Homo sapiens
-
3.4.22.B29 stomach
-
 Mus musculus
-
3.4.22.B29 stomach
-
 Homo sapiens
-
3.4.22.B29 stomach predominantly expressed in Rattus norvegicus
-
3.4.22.B30 lung
-
 Mus musculus
-
3.4.22.B30 lung
-
 Rattus norvegicus
-
3.4.22.B30 testis
-
 Macaca fascicularis
-
3.4.22.B35 optic lobe
-
 Drosophila melanogaster
-
3.4.22.54 leukocyte alternatively exon-spliced isoforms of calpain 3 expressed in human leukocytes Homo sapiens
-
3.4.22.54 skeletal muscle
-
 Sus scrofa
-
3.4.22.54 skeletal muscle
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
3.4.21.34 factor XII + H2O activation of the factor XII, bound to negatively charged surfaces Homo sapiens ?
-
 ?
3.4.21.34 factor XII + H2O activation of the factor XII, bound to negatively charged surfaces Homo sapiens ?
-
 ir
3.4.21.34 factor XII + H2O activation of the factor XII, bound to negatively charged surfaces Rattus norvegicus ?
-
 ?
3.4.21.34 factor XII + H2O activation of the factor XII, bound to negatively charged surfaces Rattus norvegicus ?
-
 ir
3.4.21.34 factor XII + H2O activation of the factor XII, bound to negatively charged surfaces Mus musculus ?
-
 ?
3.4.21.34 factor XII + H2O activation of the factor XII, bound to negatively charged surfaces Mus musculus ?
-
 ir
3.4.21.34 kininogen + H2O high-molecular weight kininogen Homo sapiens bradykinin + fragments of kininogen
-
 ?
3.4.21.34 kininogen + H2O high-molecular weight kininogen Homo sapiens bradykinin + fragments of kininogen
-
 ir
3.4.21.34 kininogen + H2O high-molecular weight kininogen Rattus norvegicus bradykinin + fragments of kininogen
-
 ?
3.4.21.34 kininogen + H2O high-molecular weight kininogen Rattus norvegicus bradykinin + fragments of kininogen
-
 ir
3.4.21.34 kininogen + H2O high-molecular weight kininogen Mus musculus bradykinin + fragments of kininogen
-
 ir
3.4.21.34 kininogen + H2O human high-molecular weight kininogen Mus musculus bradykinin + fragments of kininogen
-
 ?
3.4.21.34 additional information belongs to the peptidase family S1, plasma kallikrein subfamily Homo sapiens ?
-
 ?
3.4.21.34 additional information belongs to the peptidase family S1, plasma kallikrein subfamily Rattus norvegicus ?
-
 ?
3.4.21.34 additional information belongs to the peptidase family S1, plasma kallikrein subfamily Mus musculus ?
-
 ?
3.4.21.34 additional information defects in gene KLKB1 cause Fletcher factor deficiency, a blood coagulation defect Homo sapiens ?
-
 ?
3.4.21.34 Prorenin + H2O activation of prorenin Homo sapiens Renin + ?
-
 ir
3.4.21.34 Prorenin + H2O activation of prorenin Rattus norvegicus Renin + ?
-
 ir
3.4.21.34 Prorenin + H2O activation of prorenin Mus musculus Renin + ?
-
 ir
3.4.21.34 Prorenin + H2O activation of prorenin, involved in the renin-angiotensin system Homo sapiens Renin + ?
-
 ir
3.4.21.34 Prorenin + H2O activation of prorenin, involved in the renin-angiotensin system Rattus norvegicus Renin + ?
-
 ir
3.4.21.34 Prorenin + H2O activation of prorenin, involved in the renin-angiotensin system Mus musculus Renin + ?
-
 ir
3.4.21.35 polypeptide + H2O
-
 Homo sapiens peptides
-
 ?
3.4.22.B1 azocasein + H2O
-
 Vigna mungo ?
-
 ?
3.4.22.B1 Boc-Asn 4-nitrophenyl ester + H2O
-
 Vigna mungo Boc-Asn + 4-nitrophenol
-
 ?
3.4.22.B24 additional information limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction Bos taurus ?
-
 ?
3.4.22.B24 additional information limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction Mus musculus ?
-
 ?
3.4.22.B24 additional information limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction Sus scrofa ?
-
 ?
3.4.22.B24 additional information limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction Homo sapiens ?
-
 ?
3.4.22.B24 additional information limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction Rattus norvegicus ?
-
 ?
3.4.22.B24 peptide + H2O
-
 Bos taurus hydrolyzed peptide
-
 ?
3.4.22.B24 peptide + H2O
-
 Mus musculus hydrolyzed peptide
-
 ?
3.4.22.B24 peptide + H2O
-
 Sus scrofa hydrolyzed peptide
-
 ?
3.4.22.B24 peptide + H2O
-
 Homo sapiens hydrolyzed peptide
-
 ?
3.4.22.B24 peptide + H2O
-
 Rattus norvegicus hydrolyzed peptide
-
 ?
3.4.22.B25 peptide + H2O
-
 Rattus norvegicus hydrolyzed peptide
-
 ?
3.4.22.B25 peptide + H2O
-
 Mus musculus hydrolyzed peptide
-
 ?
3.4.22.B25 peptide + H2O
-
 Rattus norvegicus Sprague-Dawley hydrolyzed peptide
-
 ?
3.4.22.B27 peptide + H2O
-
 Homo sapiens hydrolyzed peptide
-
 ?
3.4.22.B27 peptide + H2O
-
 Mus musculus hydrolyzed peptide
-
 ?
3.4.22.B29 peptide + H2O
-
 Rattus norvegicus hydrolyzed peptide
-
 ?
3.4.22.B29 peptide + H2O
-
 Mus musculus hydrolyzed peptide
-
 ?
3.4.22.B29 peptide + H2O
-
 Homo sapiens hydrolyzed peptide
-
 ?
3.4.22.B29 peptide + H2O
-
 Mus musculus C57/BL6J hydrolyzed peptide
-
 ?
3.4.22.B30 peptide + H2O
-
 Mus musculus hydrolyzed peptide
-
 ?
3.4.22.B30 peptide + H2O
-
 Homo sapiens hydrolyzed peptide
-
 ?
3.4.22.B30 peptide + H2O
-
 Macaca fascicularis hydrolyzed peptide
-
 ?
3.4.22.B30 peptide + H2O
-
 Rattus norvegicus hydrolyzed peptide
-
 ?
3.4.22.B30 peptide + H2O proteolysis of substrates involved in cytoskeletal remodelling and signal transduction Mus musculus hydrolyzed peptide
-
 ?
3.4.22.B30 peptide + H2O
-
 Mus musculus 129/SvJ hydrolyzed peptide
-
 ?
3.4.22.B30 peptide + H2O proteolysis of substrates involved in cytoskeletal remodelling and signal transduction Mus musculus 129/SvJ hydrolyzed peptide
-
 ?
3.4.22.B31 peptide + H2O
-
 Homo sapiens hydrolyzed peptide
-
 ?
3.4.22.B31 peptide + H2O the enzyme catalyzes limited proteolysis of substrates involved in cytoskeletal remodelling and signal transduction Homo sapiens hydrolyzed peptide
-
 ?
3.4.22.B32 peptide + H2O
-
 Mus musculus hydrolyzed peptide
-
 ?
3.4.22.B35 peptide + H2O
-
 Drosophila melanogaster hydrolyzed peptide
-
 ?
3.4.22.B37 peptide + H2O
-
 Drosophila melanogaster hydrolyzed peptide
-
 ?
3.4.24.B3 protein + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.B3 protein + H2O
-
 Xenopus laevis peptides
-
 ?
3.4.24.B4 protein + H2O
-
 Bos taurus peptides
-
 ?
3.4.24.B4 protein + H2O
-
 Rattus norvegicus peptides
-
 ?
3.4.24.B4 protein + H2O
-
 Xenopus laevis peptides
-
 ?
3.4.24.B4 protein + H2O
-
 Equus caballus peptides
-
 ?
3.4.24.B5 protein + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.B5 protein + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B6 proteins + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B6 proteins + H2O
-
 Sus scrofa peptides
-
 ?
3.4.24.B8 proteins + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B8 proteins + H2O
-
 Rattus norvegicus peptides
-
 ?
3.4.24.B9 proteins + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.B9 proteins + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B11 proteins + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B11 proteins + H2O
-
 Rattus norvegicus peptides
-
 ?
3.4.24.B12 proteins + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.B12 proteins + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B12 proteins + H2O
-
 Bos taurus peptides
-
 ?
3.4.24.B14 protein + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B15 protein + H2O
-
 Homo sapiens peptides
-
 ?
3.4.24.B15 protein + H2O
-
 Mus musculus peptides
-
 ?
3.4.24.B18 protein + H2O
-
 Saccharomyces cerevisiae peptides
-
 ?
3.4.24.B19 proteins + H2O
-
 Saccharomyces cerevisiae peptides
-
 ?
3.4.24.B20 proteins + H2O
-
 Arabidopsis thaliana peptides
-
 ?

Subunits

EC Number Subunits Comment Organism
1.13.11.52 tetramer
-
 Mus musculus
3.4.22.B24 dimer heterodimer of a large and a small subunit Bos taurus
3.4.22.B24 dimer heterodimer of a large and a small subunit Mus musculus
3.4.22.B24 dimer heterodimer of a large and a small subunit Sus scrofa
3.4.22.B24 dimer heterodimer of a large and a small subunit Homo sapiens
3.4.22.B24 dimer heterodimer of a large and a small subunit Rattus norvegicus

Synonyms

EC Number Synonyms Comment Organism
1.13.11.52 TDO
-
 Mus musculus
1.13.11.52 TDO2
-
 Mus musculus
2.7.10.1 ALK tyrosine kinase receptor
-
 Homo sapiens
2.7.10.1 BDNF/NT-3 growth factors receptor
-
 Gallus gallus
2.7.10.1 epidermal growth factor receptor
-
 Drosophila melanogaster
2.7.10.1 epidermal growth factor receptor
-
 Homo sapiens
2.7.10.1 high affinity nerve growth factor receptor
-
 Homo sapiens
2.7.10.1 insulin receptor
-
 Homo sapiens
2.7.10.1 myoblast growth factor receptor egl-15
-
 Caenorhabditis elegans
2.7.10.1 NT-3 growth factor receptor
-
 Gallus gallus
2.7.10.1 proto-oncogene tyrosine-protein kinase receptor ret
-
 Homo sapiens
2.7.10.1 vascular endothelial growth factor receptor 1
-
 Homo sapiens
2.7.10.1 vascular endothelial growth factor receptor 2
-
 Rattus norvegicus
2.7.10.2 non-receptor tyrosine-protein kinase TYK2
-
 Mus musculus
2.7.10.2 Protein tyrosine kinase
-
 Danio rerio
2.7.10.2 proto-oncogene tyrosine-protein kinase ABL1
-
 Mus musculus
2.7.10.2 proto-oncogene tyrosine-protein kinase LCK
-
 Homo sapiens
2.7.10.2 proto-oncogene tyrosine-protein kinase SRC
-
 Rattus norvegicus
2.7.10.2 tyrosine-protein kinase BTK
-
 Homo sapiens
2.7.10.2 tyrosine-protein kinase Fps85D
-
 Drosophila melanogaster
2.7.10.2 tyrosine-protein kinase HCK
-
 Macaca fascicularis
2.7.10.2 tyrosine-protein kinase JAK1
-
 Danio rerio
2.7.10.2 tyrosine-protein kinase shark
-
 Drosophila melanogaster
2.7.10.2 tyrosine-protein kinase Src42A
-
 Drosophila melanogaster
2.7.10.2 tyrosine-protein kinase Src64B
-
 Drosophila melanogaster
2.7.11.1 3-phosphoinositide dependent protein kinase-1
-
 Homo sapiens
2.7.11.11 cAMP-dependent protein kinase, alpha-catalytic subunit
-
 Mus musculus
2.7.11.17 Ca2+/calmodulin-dependent protein kinase
-
 Metarhizium anisopliae
2.7.11.17 calcium/calmodulin-dependent protein kinase type II alpha chain
-
 Homo sapiens
2.7.11.17 calcium/calmodulin-dependent protein kinase type II beta chain
-
 Homo sapiens
2.7.11.17 calcium/calmodulin-dependent protein kinase type II gamma chain
-
 Mus musculus
2.7.11.18 myosin light chain kinase, smooth muscle and non-muscle isozymes
-
 Homo sapiens
3.4.21.B10 GK
-
 Mus musculus
3.4.21.B10 KAL-B
-
 Mus musculus
3.4.21.B10 protease M
-
 Homo sapiens
3.4.21.B10 SP59
-
 Homo sapiens
3.4.21.B39 GK-5
-
 Mus musculus
3.4.21.B39 K5
-
 Homo sapiens
3.4.21.B39 K5
-
 Mus musculus
3.4.21.B39 tissue kallikrein
-
 Mus musculus
3.4.21.B40 EGF-BP C
-
 Mus musculus
3.4.21.B40 epidermal growth factor-binding protein type C
-
 Mus musculus
3.4.21.B40 GK-9
-
 Mus musculus
3.4.21.B40 KLK-S3
-
 Rattus norvegicus
3.4.21.B40 S3 kallikrein
-
 Rattus norvegicus
3.4.21.B40 SEV
-
 Rattus norvegicus
3.4.21.B40 submandibular enzymatic vasocontrictor
-
 Rattus norvegicus
3.4.21.B40 tissue kallikrein
-
 Rattus norvegicus
3.4.21.B40 tissue kallikrein
-
 Mus musculus
3.4.21.B42 GK-11
-
 Mus musculus
3.4.21.B42 glandular kallikrein K11
-
 Mus musculus
3.4.21.B42 tissue kallikrein
-
 Mus musculus
3.4.21.77 7S nerve growth factor gamma chain
-
 Mus musculus
3.4.21.77 gamma-NGF
-
 Mus musculus
3.4.21.77 gamma-seminoprotein
-
 Homo sapiens
3.4.21.77 gamma-seminoprotein
-
 Macaca mulatta
3.4.21.77 GK3
-
 Mus musculus
3.4.21.77 glandular kallikrein 3
-
 Rattus norvegicus
3.4.21.77 K3
-
 Homo sapiens
3.4.21.77 K3
-
 Macaca mulatta
3.4.21.77 K3
-
 Rattus norvegicus
3.4.21.77 K3
-
 Mus musculus
3.4.21.77 tissue kallikrein
-
 Mus musculus
3.4.21.117 SCCE
-
 Homo sapiens
3.4.21.118 brain serine protease 1
-
 Rattus norvegicus
3.4.21.118 GK-8
-
 Mus musculus
3.4.21.118 NP
-
 Mus musculus
3.4.21.118 NP
-
 Homo sapiens
3.4.21.118 NP
-
 Rattus norvegicus
3.4.21.118 ovasin
-
 Homo sapiens
3.4.21.118 P1 kallikrein
-
 Rattus norvegicus
3.4.21.118 RGK-8
-
 Rattus norvegicus
3.4.21.118 TADG14
-
 Homo sapiens
3.4.21.118 tissue kallikrein
-
 Rattus norvegicus
3.4.21.119 glandular kallikrein K13
-
 Mus musculus
3.4.21.119 MGK-13
-
 Mus musculus
3.4.21.119 tissue kallikrein
-
 Mus musculus
3.4.24.B3 M10.007 Merops-ID Homo sapiens
3.4.24.B3 M10.007 Merops-ID Xenopus laevis
3.4.24.B3 matrix metalloproteinase-11
-
 Homo sapiens
3.4.24.B3 matrix metalloproteinase-11
-
 Xenopus laevis
3.4.24.B3 MMP-11
-
 Homo sapiens
3.4.24.B3 MMP-11
-
 Xenopus laevis
3.4.24.B3 SL-3
-
 Homo sapiens
3.4.24.B3 ST3
-
 Homo sapiens
3.4.24.B3 ST3
-
 Xenopus laevis
3.4.24.B4 M10.013 Merops-ID Bos taurus
3.4.24.B4 M10.013 Merops-ID Rattus norvegicus
3.4.24.B4 M10.013 Merops-ID Xenopus laevis
3.4.24.B4 M10.013 Merops-ID Equus caballus
3.4.24.B4 matrix metalloproteinase-13
-
 Bos taurus
3.4.24.B4 matrix metalloproteinase-13
-
 Rattus norvegicus
3.4.24.B4 matrix metalloproteinase-13
-
 Xenopus laevis
3.4.24.B4 matrix metalloproteinase-13
-
 Equus caballus
3.4.24.B4 MMP-13
-
 Bos taurus
3.4.24.B4 MMP-13
-
 Rattus norvegicus
3.4.24.B4 MMP-13
-
 Xenopus laevis
3.4.24.B4 MMP-13
-
 Equus caballus
3.4.24.B4 UMRCASE
-
 Rattus norvegicus
3.4.24.B5 M10.015 Merops-ID Homo sapiens
3.4.24.B5 M10.015 Merops-ID Mus musculus
3.4.24.B5 membrane-type matrix metalloproteinase 2
-
 Homo sapiens
3.4.24.B5 membrane-type matrix metalloproteinase 2
-
 Mus musculus
3.4.24.B5 membrane-type-2 matrix metalloproteinase
-
 Homo sapiens
3.4.24.B5 membrane-type-2 matrix metalloproteinase
-
 Mus musculus
3.4.24.B5 MMP-15
-
 Homo sapiens
3.4.24.B5 MMP-15
-
 Mus musculus
3.4.24.B5 MT-MMP 2
-
 Homo sapiens
3.4.24.B5 MT-MMP 2
-
 Mus musculus
3.4.24.B5 MT2-MMP
-
 Homo sapiens
3.4.24.B5 MT2-MMP
-
 Mus musculus
3.4.24.B5 MT2MMP
-
 Homo sapiens
3.4.24.B5 MT2MMP
-
 Mus musculus
3.4.24.B5 MTMMP2
-
 Homo sapiens
3.4.24.B5 MTMMP2
-
 Mus musculus
3.4.24.B5 SMCP-2
-
 Homo sapiens
3.4.24.B6 enamel metalloproteinase
-
 Mus musculus
3.4.24.B6 enamel metalloproteinase
-
 Sus scrofa
3.4.24.B6 enamelysin
-
 Mus musculus
3.4.24.B6 enamelysin
-
 Sus scrofa
3.4.24.B6 M10.019 Merops-ID Mus musculus
3.4.24.B6 M10.019 Merops-ID Sus scrofa
3.4.24.B6 MMP-20
-
 Mus musculus
3.4.24.B6 MMP-20
-
 Sus scrofa
3.4.24.B8 a disintegrin and metalloproteinase domain 1
-
 Rattus norvegicus
3.4.24.B8 a disintegrin and metalloproteinase domain 1a
-
 Mus musculus
3.4.24.B8 a disintegrin and metalloproteinase domain 1b
-
 Mus musculus
3.4.24.B8 ADAM 1
-
 Rattus norvegicus
3.4.24.B8 ADAM 1a
-
 Mus musculus
3.4.24.B8 ADAM 1b
-
 Mus musculus
3.4.24.B8 fertilin alpha 1a subunit
-
 Mus musculus
3.4.24.B8 fertilin alpha 1b subunit
-
 Mus musculus
3.4.24.B8 fertilin alpha subunit
-
 Rattus norvegicus
3.4.24.B8 M12.201 Merops-ID Mus musculus
3.4.24.B8 M12.201 Merops-ID Rattus norvegicus
3.4.24.B9 a disintegrin and metalloproteinase domain 9
-
 Homo sapiens
3.4.24.B9 ADAM9
-
 Homo sapiens
3.4.24.B9 ADAM9
-
 Mus musculus
3.4.24.B9 cellular disintegrin-related protein
-
 Homo sapiens
3.4.24.B9 cellular disintegrin-related protein precursor Mus musculus
3.4.24.B9 M12.209 Merops-ID Homo sapiens
3.4.24.B9 M12.209 Merops-ID Mus musculus
3.4.24.B9 MDC
-
 Mus musculus
3.4.24.B9 MDC9
-
 Homo sapiens
3.4.24.B9 meltrin gamma
-
 Homo sapiens
3.4.24.B9 meltrin gamma
-
 Mus musculus
3.4.24.B9 metalloprotease/disintegrin/cysteine-rich protein 9
-
 Homo sapiens
3.4.24.B9 MLTNG
-
 Mus musculus
3.4.24.B9 myeloma cell metalloproteinase
-
 Homo sapiens
3.4.24.B11 a disintegrin and metalloproteinase with thrombospondin motifs 1
-
 Mus musculus
3.4.24.B11 a disintegrin and metalloproteinase with thrombospondin motifs 1
-
 Rattus norvegicus
3.4.24.B11 ADAM-TS 1
-
 Mus musculus
3.4.24.B11 ADAM-TS 1
-
 Rattus norvegicus
3.4.24.B11 ADAM-TS1
-
 Mus musculus
3.4.24.B11 ADAM-TS1
-
 Rattus norvegicus
3.4.24.B11 M12.222 Merops-ID Mus musculus
3.4.24.B11 M12.222 Merops-ID Rattus norvegicus
3.4.24.B12 a disintegrin and metalloproteinase with thrombospondin motifs 5
-
 Homo sapiens
3.4.24.B12 a disintegrin and metalloproteinase with thrombospondin motifs 5
-
 Mus musculus
3.4.24.B12 a disintegrin and metalloproteinase with thrombospondin motifs 5
-
 Bos taurus
3.4.24.B12 ADAM-TS 5
-
 Homo sapiens
3.4.24.B12 ADAM-TS 5
-
 Mus musculus
3.4.24.B12 ADAM-TS 5
-
 Bos taurus
3.4.24.B12 ADAM-TS11
-
 Homo sapiens
3.4.24.B12 ADAM-TS11
-
 Bos taurus
3.4.24.B12 ADAM-TS5
-
 Homo sapiens
3.4.24.B12 ADAM-TS5
-
 Mus musculus
3.4.24.B12 ADAM-TS5
-
 Bos taurus
3.4.24.B12 ADMP-2
-
 Homo sapiens
3.4.24.B12 ADMP-2
-
 Mus musculus
3.4.24.B12 ADMP-2
-
 Bos taurus
3.4.24.B12 aggrecanase-2
-
 Homo sapiens
3.4.24.B12 aggrecanase-2
-
 Mus musculus
3.4.24.B12 aggrecanase-2
-
 Bos taurus
3.4.24.B12 implantin
-
 Mus musculus
3.4.24.B12 M12.225 Merops-ID Homo sapiens
3.4.24.B12 M12.225 Merops-ID Mus musculus
3.4.24.B12 M12.225 Merops-ID Bos taurus
3.4.24.B14 M13.008 Merops-ID Mus musculus
3.4.24.B15 HYP
-
 Homo sapiens
3.4.24.B15 HYP
-
 Mus musculus
3.4.24.B15 M13.091 Merops-ID Homo sapiens
3.4.24.B15 M13.091 Merops-ID Mus musculus
3.4.24.B15 metalloendopeptidase homolog PEX
-
 Homo sapiens
3.4.24.B15 metalloendopeptidase homolog PEX
-
 Mus musculus
3.4.24.B15 PEX
-
 Homo sapiens
3.4.24.B15 PEX
-
 Mus musculus
3.4.24.B15 PHEX
-
 Homo sapiens
3.4.24.B15 PHEX
-
 Mus musculus
3.4.24.B15 phosphate regulating neutral endopeptidase
-
 Mus musculus
3.4.24.B15 vitamin D-resistant hypophosphatemic rickets protein
-
 Homo sapiens
3.4.24.B15 vitamin D-resistant hypophosphatemic rickets protein
-
 Mus musculus
3.4.24.B15 X-linked hypophosphatemia protein
-
 Homo sapiens
3.4.24.B15 X-linked hypophosphatemia protein
-
 Mus musculus
3.4.24.B18 M41.003 Merops-ID Saccharomyces cerevisiae
3.4.24.B18 mitochondrial respiratory chain complexes assembly protein RCA1
-
 Saccharomyces cerevisiae
3.4.24.B18 TAT-binding homolog 12
-
 Saccharomyces cerevisiae
3.4.24.B19 M41.004 Merops-ID Saccharomyces cerevisiae
3.4.24.B19 OSD1 protein
-
 Saccharomyces cerevisiae
3.4.24.B19 TAT-binding homolog 11
-
 Saccharomyces cerevisiae
3.4.24.B19 YME1
-
 Saccharomyces cerevisiae
3.4.24.B20 M41.005 Merops-ID Arabidopsis thaliana
3.4.24.B20 putative cell division protein
-
 Arabidopsis thaliana
3.4.24.B20 zinc dependent protease
-
 Arabidopsis thaliana

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme 2 molecules of protoheme IV per tetramer Mus musculus
2.7.11.17 3-phosphoinositide enzyme is dependent on Mus musculus