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Literature summary extracted from

  • Sono, M.
    The roles of superoxide anion and methylene blue in the reductive activation of indoleamine 2,3-dioxygenase by ascorbic acid or by xanthine oxidase-hypoxanthine (1989), J. Biol. Chem., 264, 1616-1622.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.52 methylene blue acts as electron mediator from donors to the ferric dioxygenase Oryctolagus cuniculus
1.13.11.52 additional information the enzyme can be activated through different pathways either by superoxide anion or by an electron donor-methylene blue system where the dye is acting as an electron mediator from the donor to the ferric dioxygenase Oryctolagus cuniculus
1.13.11.52 O2-
-
 Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 n-butyl isocyanide heme ligand which binds tightly to the ferrous enzyme Oryctolagus cuniculus
1.13.11.52 Superoxide dismutase 80-98% inhibition Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 L-tryptophan + O2 Oryctolagus cuniculus
-
 N-formyl-L-kynurenine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Oryctolagus cuniculus
-
-
-

Oxidation Stability

EC Number Oxidation Stability Organism
1.13.11.52 leuco-methylene blue reduces ferric enzyme Oryctolagus cuniculus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 small intestine
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 D-tryptophan + O2
-
 Oryctolagus cuniculus N-formyl-D-kynurenine
-
 ?
1.13.11.52 L-Trp + O2
-
 Oryctolagus cuniculus L-formylkynurenine
-
 ?
1.13.11.52 L-tryptophan + O2
-
 Oryctolagus cuniculus N-formyl-L-kynurenine
-
 ?