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Literature summary extracted from

  • Sono, M.
    Spectroscopic and equilibrium studies of ligand and organic substrate binding to indolamine 2,3-dioxygenase (1990), Biochemistry, 29, 1451-1460.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.52 additional information IDO can bind following substances as ligand in effector binding site: alkyl isocyanides, CN-, F-, N3-, imidazoles, pyridines, formate, benzhydroxamate, phosphines Oryctolagus cuniculus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.52 CO negatively cooperative Oryctolagus cuniculus
1.13.11.52 imidazole negatively cooperative or competitive Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.52 0.0065
-
L-tryptophan pH 8.0 Oryctolagus cuniculus
1.13.11.52 0.009
-
L-tryptophan pH 7.5 Oryctolagus cuniculus
1.13.11.52 0.013
-
L-tryptophan pH 7.0 Oryctolagus cuniculus
1.13.11.52 0.025
-
L-tryptophan pH 6.5 Oryctolagus cuniculus
1.13.11.52 0.05
-
L-tryptophan pH 6.0 Oryctolagus cuniculus
1.13.11.52 0.25
-
L-tryptophan pH 5.5 Oryctolagus cuniculus

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.52 CN- enhances the affinity for L-tryptophan for the ferric enzyme in reziprocal manner, positive cooperativity Oryctolagus cuniculus
1.13.11.52 F- enhances the affinity for L-tryptophan for the ferric enzyme in reziprocal manner, positive cooperativity Oryctolagus cuniculus
1.13.11.52 N3- enhances the affinity for L-tryptophan for the ferric enzyme in reziprocal manner, positive cooperativity Oryctolagus cuniculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.52 D-tryptophan + O2 Oryctolagus cuniculus
-
N-formyl-D-kynurenine
-
?
1.13.11.52 L-tryptophan + O2 Oryctolagus cuniculus higher affinity at alkaline pH than at acidic pH N-formyl-L-kynurenine
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.52 Oryctolagus cuniculus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.52 small intestine
-
Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.52 D-tryptophan + O2
-
Oryctolagus cuniculus N-formyl-D-kynurenine
-
?
1.13.11.52 L-Trp + O2
-
Oryctolagus cuniculus L-formylkynurenine
-
?
1.13.11.52 L-tryptophan + O2 higher affinity at alkaline pH than at acidic pH Oryctolagus cuniculus N-formyl-L-kynurenine
-
?

Cofactor

EC Number Cofactor Comment Organism Structure
1.13.11.52 heme the environmental structure of the active-site heme pocket is similar but the size is considerably larger than that of myoglobin Oryctolagus cuniculus