EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.52 | additional information | IDO can bind following substances as ligand in effector binding site: alkyl isocyanides, CN-, F-, N3-, imidazoles, pyridines, formate, benzhydroxamate, phosphines | Oryctolagus cuniculus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.52 | CO | negatively cooperative | Oryctolagus cuniculus | |
1.13.11.52 | imidazole | negatively cooperative or competitive | Oryctolagus cuniculus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.13.11.52 | 0.0065 | - |
L-tryptophan | pH 8.0 | Oryctolagus cuniculus | |
1.13.11.52 | 0.009 | - |
L-tryptophan | pH 7.5 | Oryctolagus cuniculus | |
1.13.11.52 | 0.013 | - |
L-tryptophan | pH 7.0 | Oryctolagus cuniculus | |
1.13.11.52 | 0.025 | - |
L-tryptophan | pH 6.5 | Oryctolagus cuniculus | |
1.13.11.52 | 0.05 | - |
L-tryptophan | pH 6.0 | Oryctolagus cuniculus | |
1.13.11.52 | 0.25 | - |
L-tryptophan | pH 5.5 | Oryctolagus cuniculus |
EC Number | Metals/Ions | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.52 | CN- | enhances the affinity for L-tryptophan for the ferric enzyme in reziprocal manner, positive cooperativity | Oryctolagus cuniculus | |
1.13.11.52 | F- | enhances the affinity for L-tryptophan for the ferric enzyme in reziprocal manner, positive cooperativity | Oryctolagus cuniculus | |
1.13.11.52 | N3- | enhances the affinity for L-tryptophan for the ferric enzyme in reziprocal manner, positive cooperativity | Oryctolagus cuniculus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.52 | D-tryptophan + O2 | Oryctolagus cuniculus | - |
N-formyl-D-kynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | Oryctolagus cuniculus | higher affinity at alkaline pH than at acidic pH | N-formyl-L-kynurenine | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.13.11.52 | Oryctolagus cuniculus | - |
- |
- |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.13.11.52 | small intestine | - |
Oryctolagus cuniculus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.13.11.52 | D-tryptophan + O2 | - |
Oryctolagus cuniculus | N-formyl-D-kynurenine | - |
? | |
1.13.11.52 | L-Trp + O2 | - |
Oryctolagus cuniculus | L-formylkynurenine | - |
? | |
1.13.11.52 | L-tryptophan + O2 | higher affinity at alkaline pH than at acidic pH | Oryctolagus cuniculus | N-formyl-L-kynurenine | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.13.11.52 | heme | the environmental structure of the active-site heme pocket is similar but the size is considerably larger than that of myoglobin | Oryctolagus cuniculus |