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Literature summary extracted from

  • Nie, D.; Tang, K.; Diglio, C.; Honn, K.V.
    Eicosanoid regulation of angiogenesis: role of endothelial arachidonate 12-lipoxygenase (2000), Blood, 95, 2304-2311.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.31 N-benzyl-N-hydroxy-5-phenylpentanamide
-
 Homo sapiens
1.13.11.31 N-benzyl-N-hydroxy-5-phenylpentanamide
-
 Mus musculus
1.13.11.31 N-benzyl-N-hydroxy-5-phenylpentanamide
-
 Rattus norvegicus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.13.11.31 additional information Mus musculus the 12-lipoxygenase pathway plays a critical role in angiogenesis ?
-
 ?
1.13.11.31 additional information Homo sapiens the 12-lipoxygenase pathway plays a critical role in angiogenesis ?
-
 ?
1.13.11.31 additional information Rattus norvegicus the 12-lipoxygenase pathway plays a critical role in angiogenesis ?
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Homo sapiens
-
-
-
1.13.11.31 Mus musculus
-
-
-
1.13.11.31 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.31 endothelial cell cell line RV-ECT Rattus norvegicus
-
1.13.11.31 endothelial cell capillary endothelial cell line CD4 Mus musculus
-
1.13.11.31 endothelial cell umbelical vein endothelial cells and foreskin dermal microvascular endothelial cells Homo sapiens
-
1.13.11.31 prepuce
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 arachidonate + O2 i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid Mus musculus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 arachidonate + O2 i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid Homo sapiens (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 arachidonate + O2 i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid Rattus norvegicus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 additional information the 12-lipoxygenase pathway plays a critical role in angiogenesis Mus musculus ?
-
 ?
1.13.11.31 additional information the 12-lipoxygenase pathway plays a critical role in angiogenesis Homo sapiens ?
-
 ?
1.13.11.31 additional information the 12-lipoxygenase pathway plays a critical role in angiogenesis Rattus norvegicus ?
-
 ?