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Literature summary extracted from

  • Moody, J.S.; Marnett, L.J.
    Kinetics of Inhibition of Leukocyte 12-Lipoxygenase by the Isoform-Specific Inhibitor 4-(2-Oxapentadeca-4-yne)phenylpropanoic Acid (2002), Biochemistry, 41, 10297-10303.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.31 4-(2-oxapentadeca-4-yne)phenylpropanoic acid mixed type inhibition towards the ferric form of 12-lipoxygenase Sus scrofa
1.13.11.31 5,8,11,14-Eicosatetraynoic acid
-
 Sus scrofa
1.13.11.31 BWA137C
-
 Sus scrofa
1.13.11.31 N-(4-chlorophenyl)-N-hydroxy-N'-(3-chlorophenyl)urea
-
 Sus scrofa
1.13.11.31 nordihydroguaiaretic acid
-
 Sus scrofa

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.31 Iron enzyme contains iron Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Sus scrofa
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.31 leukocyte
-
 Sus scrofa
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 arachidonate + O2 i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid Sus scrofa (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.13.11.31 0.002
-
 4-(2-oxapentadeca-4-yne)phenylpropanoic acid inhibition of the ferric form of 12-lipoxygenase, free enzyme Sus scrofa
1.13.11.31 0.0045
-
 4-(2-oxapentadeca-4-yne)phenylpropanoic acid inhibition of the ferric form of 12-lipoxygenase, substrate-bound form of enzyme Sus scrofa
1.13.11.31 0.07
-
 4-(2-oxapentadeca-4-yne)phenylpropanoic acid inhibition of the ferrous form of 12-lipoxygenase Sus scrofa