Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Takahashi, Y.; Ueda, N.; Yamamoto, S.
    Two immunologically and catalytically distinct arachidonate 12-lipoxygenases of bovine platelets and leukocytes (1988), Arch. Biochem. Biophys., 266, 613-621.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.31 cytosol
-
 Bos taurus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.31 Bos taurus
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.31 partial Bos taurus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.31 leukocyte
-
 Bos taurus
-
1.13.11.31 platelet
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.13.11.31 0.0003
-
 enzyme from platelet Bos taurus
1.13.11.31 0.0011
-
 enzyme from leukocyte Bos taurus

Storage Stability

EC Number Storage Stability Organism
1.13.11.31 -80°C, stable for at least 1 week Bos taurus
1.13.11.31 4°C, half-life of leukocyte enzyme is 2 h, half-life of platelet enzyme is 70 h Bos taurus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.31 11,14,17-eicosatrienoic acid + O2 leukocyte enzyme: 28% of the activity with arachidonic acid, platelet enzyme: less than 2% of the activity with arachidonic acid Bos taurus ?
-
 ?
1.13.11.31 11,14-eicosadienoic acid + O2 leukocyte enzyme: 15% of the activity with arachidonic acid, platelet enzyme: less than 2% of the activity with arachidonic acid Bos taurus ?
-
 ?
1.13.11.31 15(S)-hydroperoxy-5Z,8Z,11Z,13E-eicosatetraenoic acid + O2 leukocyte enzyme: 18% of the activity with arachidonic acid, platelet enzyme: 6% of the activity with arachidonic acid Bos taurus additional information
-
 ?
1.13.11.31 4,7,10,13,16,19-docosahexaenoic acid + O2 leukocyte enzyme: 92% of the activity with arachidonic acid, platelet enzyme: 7% of the activity with arachidonic acid Bos taurus ?
-
 ?
1.13.11.31 5(S)-hydroxy-6E,8Z,11Z,14Z-eicosatetraenoic acid + O2 leukocyte enzyme: 15% of the activity with arachidonic acid, platelet enzyme: less than 2% of the activity with arachidonic acid Bos taurus 5,12-(5S,12S)-dihydroxy-6E,8Z,10E,14Z-eicosatetraenoic acid + 5,12-(5S,15S)-dihydroxy-6E,8Z,11Z,13E-eicosatetraenoic acid
-
 ?
1.13.11.31 5,8,11,14,17-eicosapentaenoic acid + O2 leukocyte enzyme: 73% of the activity with arachidonic acid, platelet enzyme: less than 94% of the activity with arachidonic acid Bos taurus 12-hydroxy-5,8,10,14,17-eicosapentaenoic acid
-
 ?
1.13.11.31 8,11,14-eicosatrienoic acid + O2 leukocyte enzyme: 78% of the activity with arachidonic acid, platelet enzyme: 7% of the activity with arachidonic acid Bos taurus 12-hydroxyeicosatrienoic acid
-
 ?
1.13.11.31 alpha-linolenic acid + O2 leukocyte enzyme: 17% of the activity with arachidonic acid, platelet enzyme: less than 2% of the activity with arachidonic acid Bos taurus ?
-
 ?
1.13.11.31 arachidonate + O2 i.e. 5Z,8Z,11Z,14Z-eicosatetraenoic acid Bos taurus (5Z,8Z,10E,14Z)-(12S)-12-hydroperoxyicosa-5,8,10,14-tetraenoate
-
 ?
1.13.11.31 gamma-linolenic acid + O2 leukocyte enzyme: 32% of the activity with arachidonic acid, platelet enzyme: less than 2% of the activity with arachidonic acid Bos taurus 10-hydroxy-octadeca-6Z,8E,12Z-trienoic acid
-
 ?
1.13.11.31 linoleic acid + O2 leukocyte enzyme: 11% of the activity with arachidonic acid, platelet enzyme: less than 2% of the activity with arachidonic acid Bos taurus 13(S)-hydroperoxy-9Z,11E-octadecadienoic acid
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.31 7 8
-
 Bos taurus