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Literature summary extracted from

  • Fellman, J.H.; Fujita, T.S.; Roth, E.S.
    Assay, properties and tissue distribution of p-hydroxyphenylpyruvate hydroxylase (1972), Biochim. Biophys. Acta, 284, 90-100.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.27 4-hydroxyphenylpyruvate
-
 Rattus norvegicus
1.13.11.27 o-hydroxyphenylpyruvate competitive inhibitor of 4-hydroxyphenylpyruvate Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.27 0.05
-
 4-hydroxyphenylpyruvate
-
 Rattus norvegicus
1.13.11.27 0.05
-
 3,4-Dihydroxyphenylpyruvate
-
 Rattus norvegicus
1.13.11.27 0.06
-
 phenylpyruvate
-
 Rattus norvegicus
1.13.11.27 0.1
-
 O2
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.13.11.27 cytosol
-
 Rattus norvegicus 5829
-

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.27 Didelphidae
-
-
-
1.13.11.27 Oncorhynchus mykiss
-
-
-
1.13.11.27 Platyrrhini
-
-
-
1.13.11.27 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.27 kidney
-
 Rattus norvegicus
-
1.13.11.27 kidney
-
 Platyrrhini
-
1.13.11.27 liver
-
 Rattus norvegicus
-
1.13.11.27 liver
-
 Oncorhynchus mykiss
-
1.13.11.27 liver
-
 Didelphidae
-
1.13.11.27 additional information
-
 Oncorhynchus mykiss
-
1.13.11.27 additional information
-
 Didelphidae
-
1.13.11.27 additional information no activity detected in heart, muscle and brain Rattus norvegicus
-
1.13.11.27 additional information no activity detected in heart, muscle and brain Platyrrhini
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.13.11.27 additional information
-
 methods for assay Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.27 3,4-dihydroxyphenylpyruvate + O2
-
 Rattus norvegicus ? + CO2
-
 ?
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Rattus norvegicus homogentisate + CO2
-
 ?
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Platyrrhini homogentisate + CO2
-
 ?
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Oncorhynchus mykiss homogentisate + CO2
-
 ?
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Didelphidae homogentisate + CO2
-
 ?
1.13.11.27 phenylpyruvate + O2
-
 Rattus norvegicus 2-hydroxyphenylacetate + CO2
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.27 7.5
-
-
 Rattus norvegicus