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Literature summary extracted from

  • Lindstedt, S.; Odelhoeg, B.
    4-Hydroxyphenylpyruvate dioxygenase from human liver (1987), Methods Enzymol., 142, 139-142.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.13.11.27 2,6-dichlorophenol indophenol reducing cofactor required, either ascorbate, or a combination of 2,6-dichlorophenol indophenol and glutathione Homo sapiens
1.13.11.27 ascorbate reducing cofactor required, either ascorbate, or a combination of 2,6-dichlorophenol indophenol and glutathione in presence of catalase Homo sapiens
1.13.11.27 glutathione reducing cofactor required, either ascorbate, or a combination of 2,6-dichlorophenol indophenol and glutathione in presence of catalase Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.13.11.27 Fe2+-chelators
-
 Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.13.11.27 additional information
-
 additional information
-
 Homo sapiens
1.13.11.27 0.05
-
 O2
-
 Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.13.11.27 Fe2+ restores activity after inactivation by Fe2+-chelators Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.13.11.27 43000
-
 2 * 43000, SDS-PAGE Homo sapiens
1.13.11.27 87000
-
 equilibrium sedimentation Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.13.11.27 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.13.11.27
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.13.11.27 liver
-
 Homo sapiens
-

Storage Stability

EC Number Storage Stability Organism
1.13.11.27 -60°C, stable for several months Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.13.11.27 4-hydroxyphenylpyruvate + O2
-
 Homo sapiens homogentisate + CO2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.13.11.27 dimer 2 * 43000, SDS-PAGE Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.13.11.27 4.5
-
 and a second optimum at pH 7.8 Homo sapiens
1.13.11.27 7.8
-
 and a second optimum at pH 4.5 Homo sapiens