Any feedback?
Please rate this page
(literature.php)
(0/150)

BRENDA support

Literature summary extracted from

  • Liu, S.Y.; Stadtman, T.
    Heparin-binding properties of selenium-containing thioredoxin reductase from HeLa cells and human lung adenocarcinoma cells (1997), Proc. Natl. Acad. Sci. USA, 94, 6138-6141.
    View publication on PubMedView publication on EuropePMC

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.8.1.9 cysteine part of the active site Homo sapiens

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.1.9 selenocysteine contains selenocysteine as part of the redox active selenosulfide in the active center Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.1.9 57000
-
 2 * 57000, SDS-PAGE Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Homo sapiens
-
 HeLa cells
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 HeLa cell high and low affinity form with respect to heparin Homo sapiens
-
1.8.1.9 lung adenocarcinoma cells, high and low affinity form with respect to heparin Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH i.e. DTNB Homo sapiens 2-nitro-5-thiobenzoate + NADP+
-
 ?
1.8.1.9 5,5'-dithiobis(2-nitrobenzoic acid) + NADPH coupled assay Homo sapiens 2-nitro-5-thiobenzoate + NADP+
-
 ?
1.8.1.9 thioredoxin + NADP+ coupled assay with DTNB Homo sapiens thioredoxin disulfide + NADPH
-
 ?
1.8.1.9 thioredoxin + NADP+ coupled assay, measurement of NADPH oxidation in presence of insulin and thioredoxin Homo sapiens thioredoxin disulfide + NADPH
-
 ?
1.8.1.9 thioredoxin + NADP+ in presence of NADPH, coupled assay Homo sapiens thioredoxin disulfide + NADPH + H+
-
 ?

Subunits

EC Number Subunits Comment Organism
1.8.1.9 dimer 2 * 57000, SDS-PAGE Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 FAD
-
 Homo sapiens
1.8.1.9 NADPH
-
 Homo sapiens