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Literature summary extracted from

  • Schallreuter, K.U.; Wood, J.M.
    The role of thioredoxin reductase in the reduction of free radicals at the surface of the epidermis (1986), Biochem. Biophys. Res. Commun., 136, 630-637.
    View publication on PubMed

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.1.9 cytoplasmic membrane
-
 Homo sapiens
-
-
1.8.1.9 extracellular
-
 Cavia porcellus
-
-
1.8.1.9 extracellular
-
 Homo sapiens
-
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.1.9 thioredoxin + NADP+ Cavia porcellus radical reduction, prevention of cells from UV-generated free radical caused damage on the skin thioredoxin disulfide + NADPH
-
 ?
1.8.1.9 thioredoxin + NADP+ Homo sapiens radical reduction, prevention of cells from UV-generated free radical caused damage on the skin thioredoxin disulfide + NADPH
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.9 Cavia porcellus
-
 guinea pig
-
1.8.1.9 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.1.9
-
 Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
1.8.1.9 thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ UV-light radical reduction mechanism Cavia porcellus
a
1.8.1.9 thioredoxin + NADP+ = thioredoxin disulfide + NADPH + H+ UV-light radical reduction mechanism Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.1.9 keratinocyte
-
 Cavia porcellus
-
1.8.1.9 keratinocyte
-
 Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.9 thioredoxin + NADP+
-
 Cavia porcellus thioredoxin disulfide + NADPH
-
 ?
1.8.1.9 thioredoxin + NADP+ coupled assay with nitroxide reductase Homo sapiens thioredoxin disulfide + NADPH
-
 ?
1.8.1.9 thioredoxin + NADP+ radical reduction, prevention of cells from UV-generated free radical caused damage on the skin Cavia porcellus thioredoxin disulfide + NADPH
-
 ?
1.8.1.9 thioredoxin + NADP+ radical reduction, prevention of cells from UV-generated free radical caused damage on the skin Homo sapiens thioredoxin disulfide + NADPH
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.9 NADPH
-
 Cavia porcellus
1.8.1.9 NADPH
-
 Homo sapiens