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Literature summary extracted from

  • Wilkinson, S.R.; Meyer, D.J.; Kelly, J.M.
    Biochemical characterization of a trypanosome enzyme with glutathione-dependent peroxidase activity (2000), Biochem. J., 352, 755-761.
    View publication on PubMedView publication on EuropePMC

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.11.1.12 His-tagged protein termed TcGPX1, expression in Escherichia coli Trypanosoma cruzi

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.11.1.12 0.00058
-
 linoleic acid hydroperoxide recombinant enzyme Trypanosoma cruzi
1.11.1.12 0.00074
-
 L-alpha-phosphatidylcholine hydroperoxide recombinant enzyme Trypanosoma cruzi
1.11.1.12 0.0017
-
 cumene hydroperoxide recombinant enzyme Trypanosoma cruzi
1.11.1.12 0.0056
-
 tert-butyl hydroperoxide recombinant enzyme Trypanosoma cruzi

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.12 Trypanosoma cruzi
-
 American trypanosome
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.11.1.12 recombinant enzyme from Escherichia coli Trypanosoma cruzi

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.12 glutathione + cumene hydroperoxide
-
 Trypanosoma cruzi ?
-
 ?
1.11.1.12 glutathione + H2O2
-
 Trypanosoma cruzi ?
-
 ?
1.11.1.12 glutathione + L-alpha-phosphatidylcholine hydroperoxide
-
 Trypanosoma cruzi ?
-
 ?
1.11.1.12 glutathione + linoleic acid hydroperoxide
-
 Trypanosoma cruzi ?
-
 ?
1.11.1.12 glutathione + lipid hydroperoxide
-
 Trypanosoma cruzi glutathione disulfide + lipid + H2O
-
 ?
1.11.1.12 glutathione + tert-butyl hydroperoxide
-
 Trypanosoma cruzi ?
-
 ?