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Literature summary extracted from

  • Saito, Y.; Hayashi, T.; Tanaka, A.; Watanabe, Y.; Suzuki, M.; Saito, E.; Takahashi, K.
    Selenoprotein P in human plasma as an extracellular phospholipid hydroperoxide glutathione peroxidase. Isolation and enzymatic characterization of human selenoprotein P (1999), J. Biol. Chem., 274, 2866-2871.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.11.1.12 deoxycholate activity is slightly enhanced, but is enhanced by 50% together with Triton X-100 Homo sapiens
1.11.1.12 Triton X-100
-
Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.11.1.12 additional information extracellular localisation Homo sapiens
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.11.1.12 Se 10 selenocysteines per protein molecule Homo sapiens

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.11.1.12 66000
-
1 * 66000, SDS-PAGE Homo sapiens
1.11.1.12 69000
-
native PAGE Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.11.1.12 glutathione + lipid hydroperoxide Homo sapiens protection of biomembranes against oxidative damage glutathione disulfide + lipid + H2O
-
?

Organism

EC Number Organism UniProt Comment Textmining
1.11.1.12 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.11.1.12
-
Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
1.11.1.12 2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O tert-uni ping-pong mechanism Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.11.1.12 plasma extracellular localisation Homo sapiens
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.11.1.12 2.03
-
addition of Triton X-100 and deoxycholate Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.11.1.12 glutathione + 1-palmitoyl-2-(13-hydroperoxy-cis-9,trans-11-octadecadienoyl)-3-phosphatidylcholine
-
Homo sapiens ?
-
?
1.11.1.12 glutathione + H2O2 no activity Homo sapiens ?
-
?
1.11.1.12 glutathione + lipid hydroperoxide dithiothreitol, 2-mercaptoethanol, cysteine and homocysteine also serve as reducing agents Homo sapiens glutathione disulfide + lipid + H2O
-
?
1.11.1.12 glutathione + lipid hydroperoxide protection of biomembranes against oxidative damage Homo sapiens glutathione disulfide + lipid + H2O
-
?
1.11.1.12 glutathione + tert-butyl hydroperoxide no activity Homo sapiens ?
-
?

Subunits

EC Number Subunits Comment Organism
1.11.1.12 monomer 1 * 66000, SDS-PAGE Homo sapiens

Synonyms

EC Number Synonyms Comment Organism
1.11.1.12 selenoprotein P
-
Homo sapiens

Temperature Optimum [°C]

EC Number Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
1.11.1.12 37
-
assay at Homo sapiens

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.11.1.12 8
-
assay at Homo sapiens