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Literature summary extracted from
- Phospholipid hydroperoxide glutathione peroxidase (1990), Methods Enzymol., 186, 448-457.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.11.1.12 | cytosol | - |
Rattus norvegicus | 5829 | - |
| 1.11.1.12 | cytosol | - |
Sus scrofa | 5829 | - |
| 1.11.1.12 | microsome | - |
Rattus norvegicus | - |
- |
| 1.11.1.12 | microsome | - |
Sus scrofa | - |
- |
| 1.11.1.12 | microsome | - |
Bos taurus | - |
- |
| 1.11.1.12 | microsome | - |
Canis lupus familiaris | - |
- |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.11.1.12 | Se | enzyme contains a selenocysteine residue at the active site | Rattus norvegicus |  |
| 1.11.1.12 | Se | enzyme contains a selenocysteine residue at the active site | Sus scrofa | |
| 1.11.1.12 | Se | enzyme contains a selenocysteine residue at the active site | Bos taurus | |
| 1.11.1.12 | Se | enzyme contains a selenocysteine residue at the active site | Canis lupus familiaris | |
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.12 | 20000 | - |
- |
Rattus norvegicus |
| 1.11.1.12 | 20000 | - |
- |
Sus scrofa |
| 1.11.1.12 | 20000 | - |
- |
Bos taurus |
| 1.11.1.12 | 20000 | - |
- |
Canis lupus familiaris |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.12 | glutathione + lipid hydroperoxide | Rattus norvegicus | protection of biomembranes against oxidative damage | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | glutathione + lipid hydroperoxide | Sus scrofa | protection of biomembranes against oxidative damage | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | glutathione + lipid hydroperoxide | Bos taurus | protection of biomembranes against oxidative damage | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | glutathione + lipid hydroperoxide | Canis lupus familiaris | protection of biomembranes against oxidative damage | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | additional information | Rattus norvegicus | enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes | ? | - |
? | |
| 1.11.1.12 | additional information | Sus scrofa | enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes | ? | - |
? | |
| 1.11.1.12 | additional information | Bos taurus | enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes | ? | - |
? | |
| 1.11.1.12 | additional information | Canis lupus familiaris | enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.11.1.12 | Bos taurus | - |
- |
- |
| 1.11.1.12 | Canis lupus familiaris | - |
- |
- |
| 1.11.1.12 | Rattus norvegicus | - |
- |
- |
| 1.11.1.12 | Sus scrofa | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.11.1.12 | - |
Sus scrofa |
Reaction
| EC Number | Reaction | Comment | Organism | Reaction ID |
|---|---|---|---|---|
| 1.11.1.12 | 2 glutathione + a hydroperoxy-fatty-acyl-[lipid] = glutathione disulfide + a hydroxy-fatty-acyl-[lipid] + H2O | ping-pong mechanism with formation of ternary complexes | Sus scrofa |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.11.1.12 | brain | - |
Rattus norvegicus | - |
| 1.11.1.12 | brain | - |
Sus scrofa | - |
| 1.11.1.12 | brain | - |
Bos taurus | - |
| 1.11.1.12 | brain | - |
Canis lupus familiaris | - |
| 1.11.1.12 | heart | - |
Rattus norvegicus | - |
| 1.11.1.12 | heart | - |
Sus scrofa | - |
| 1.11.1.12 | heart | - |
Bos taurus | - |
| 1.11.1.12 | kidney | - |
Rattus norvegicus | - |
| 1.11.1.12 | kidney | - |
Sus scrofa | - |
| 1.11.1.12 | kidney | - |
Bos taurus | - |
| 1.11.1.12 | kidney | - |
Canis lupus familiaris | - |
| 1.11.1.12 | liver | - |
Rattus norvegicus | - |
| 1.11.1.12 | liver | - |
Sus scrofa | - |
| 1.11.1.12 | liver | - |
Bos taurus | - |
| 1.11.1.12 | liver | - |
Canis lupus familiaris | - |
| 1.11.1.12 | lung | - |
Rattus norvegicus | - |
| 1.11.1.12 | muscle | - |
Rattus norvegicus | - |
| 1.11.1.12 | spermatozoon | - |
Rattus norvegicus | - |
| 1.11.1.12 | spermatozoon | - |
Bos taurus | - |
| 1.11.1.12 | testis | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.12 | 0.0062 | - |
- |
Rattus norvegicus |
| 1.11.1.12 | 310.1 | - |
purified enzyme | Sus scrofa |
Storage Stability
| EC Number | Storage Stability | Organism |
|---|---|---|
| 1.11.1.12 | -20°C, 10% glycerol, stable for several months | Sus scrofa |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.11.1.12 | glutathione + cholesterol hydroperoxides | - |
Rattus norvegicus | ? | - |
? | |
| 1.11.1.12 | glutathione + cholesterol hydroperoxides | - |
Sus scrofa | ? | - |
? | |
| 1.11.1.12 | glutathione + cholesterol hydroperoxides | - |
Bos taurus | ? | - |
? | |
| 1.11.1.12 | glutathione + cholesterol hydroperoxides | - |
Canis lupus familiaris | ? | - |
? | |
| 1.11.1.12 | glutathione + fatty acid hydroperoxides | - |
Sus scrofa | ? | - |
? | |
| 1.11.1.12 | glutathione + H2O2 | - |
Rattus norvegicus | ? | - |
? | |
| 1.11.1.12 | glutathione + H2O2 | - |
Sus scrofa | ? | - |
? | |
| 1.11.1.12 | glutathione + H2O2 | - |
Bos taurus | ? | - |
? | |
| 1.11.1.12 | glutathione + H2O2 | - |
Canis lupus familiaris | ? | - |
? | |
| 1.11.1.12 | glutathione + lipid hydroperoxide | - |
Rattus norvegicus | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | glutathione + lipid hydroperoxide | - |
Bos taurus | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | glutathione + lipid hydroperoxide | - |
Canis lupus familiaris | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | glutathione + lipid hydroperoxide | wide specificity for lipid hydroperoxides | Sus scrofa | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | glutathione + lipid hydroperoxide | the oxidized active site of the enzyme can also be reduced by mercaptoethanol | Sus scrofa | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | glutathione + lipid hydroperoxide | protection of biomembranes against oxidative damage | Rattus norvegicus | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | glutathione + lipid hydroperoxide | protection of biomembranes against oxidative damage | Sus scrofa | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | glutathione + lipid hydroperoxide | protection of biomembranes against oxidative damage | Bos taurus | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | glutathione + lipid hydroperoxide | protection of biomembranes against oxidative damage | Canis lupus familiaris | glutathione disulfide + lipid + H2O | - |
? | |
| 1.11.1.12 | glutathione + phospholipid hydroperoxides | - |
Rattus norvegicus | ? | - |
? | |
| 1.11.1.12 | glutathione + phospholipid hydroperoxides | - |
Sus scrofa | ? | - |
? | |
| 1.11.1.12 | glutathione + phospholipid hydroperoxides | - |
Bos taurus | ? | - |
? | |
| 1.11.1.12 | glutathione + tert-butyl hydroperoxide | - |
Rattus norvegicus | ? | - |
? | |
| 1.11.1.12 | glutathione + tert-butyl hydroperoxide | - |
Sus scrofa | ? | - |
? | |
| 1.11.1.12 | glutathione + tert-butyl hydroperoxide | - |
Bos taurus | ? | - |
? | |
| 1.11.1.12 | glutathione + tert-butyl hydroperoxide | - |
Canis lupus familiaris | ? | - |
? | |
| 1.11.1.12 | additional information | reduces hydroxyperoxide derivatives of phospholipids into alcohol derivatives | Rattus norvegicus | ? | - |
? | |
| 1.11.1.12 | additional information | reduces hydroxyperoxide derivatives of phospholipids into alcohol derivatives | Sus scrofa | ? | - |
? | |
| 1.11.1.12 | additional information | reduces hydroxyperoxide derivatives of phospholipids into alcohol derivatives | Bos taurus | ? | - |
? | |
| 1.11.1.12 | additional information | reduces hydroxyperoxide derivatives of phospholipids into alcohol derivatives | Canis lupus familiaris | ? | - |
? | |
| 1.11.1.12 | additional information | enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes | Rattus norvegicus | ? | - |
? | |
| 1.11.1.12 | additional information | enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes | Sus scrofa | ? | - |
? | |
| 1.11.1.12 | additional information | enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes | Bos taurus | ? | - |
? | |
| 1.11.1.12 | additional information | enzyme inhibits lipid peroxidation, which is induced by Fe3+-triethylenetetramine complex, NADPH and ascorbate in presence of glutathione, therefore a physiological amount of alpha-tocopherol, vitamin E, is necessary in the membranes | Canis lupus familiaris | ? | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.11.1.12 | monomer | - |
Rattus norvegicus |
| 1.11.1.12 | monomer | - |
Bos taurus |
| 1.11.1.12 | monomer | - |
Canis lupus familiaris |
| 1.11.1.12 | monomer | 1 * 20000, SDS-PAGE | Sus scrofa |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.12 | 37 | - |
assay at | Rattus norvegicus |
| 1.11.1.12 | 37 | - |
assay at | Sus scrofa |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.11.1.12 | 7.4 | - |
assay at | Rattus norvegicus |
| 1.11.1.12 | 7.4 | - |
assay at | Sus scrofa |
| 1.11.1.12 | 7.4 | - |
assay at | Bos taurus |
| 1.11.1.12 | 7.4 | - |
assay at | Canis lupus familiaris |
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