BRENDA - Enzyme Database

Insulin degradation. II. The widespread distribution of glutathione-insulin transhydrogenase in the tissues of the rat

Chandler, M.L.; Varandani, P.T.; Biochim. Biophys. Acta 286, 136-145 (1972)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Bos taurus
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Rattus norvegicus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.8.4.2
additional information
-
additional information
-
Bos taurus
1.8.4.2
additional information
-
additional information
Km in different tissues for GSH and insulin
Rattus norvegicus
1.8.4.2
0.003
0.012
Insulin
enzymes from different rat tissues
Rattus norvegicus
1.8.4.2
0.8
1.7
GSH
enzyme from different rat tissues
Rattus norvegicus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.8.4.2
Bos taurus
-
-
-
1.8.4.2
Rattus norvegicus
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
1.8.4.2
-
Bos taurus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.4.2
adipose tissue
-
Rattus norvegicus
-
1.8.4.2
brain
-
Rattus norvegicus
-
1.8.4.2
diaphragm
-
Rattus norvegicus
-
1.8.4.2
heart
-
Rattus norvegicus
-
1.8.4.2
heart
-
Bos taurus
-
1.8.4.2
intestine
-
Rattus norvegicus
-
1.8.4.2
kidney
-
Rattus norvegicus
-
1.8.4.2
kidney
-
Bos taurus
-
1.8.4.2
liver
-
Bos taurus
-
1.8.4.2
liver
-
Rattus norvegicus
-
1.8.4.2
lung
-
Rattus norvegicus
-
1.8.4.2
additional information
relative activities of enzyme in various tissues
Rattus norvegicus
-
1.8.4.2
additional information
relative activities of enzyme in various tissues
Bos taurus
-
1.8.4.2
pancreas
-
Rattus norvegicus
-
1.8.4.2
pancreas
-
Bos taurus
-
1.8.4.2
skeletal muscle
-
Rattus norvegicus
-
1.8.4.2
spleen
-
Rattus norvegicus
-
1.8.4.2
testis
-
Rattus norvegicus
-
1.8.4.2
thymus
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
1.8.4.2
additional information
-
-
Bos taurus
1.8.4.2
additional information
-
tissue distribution
Rattus norvegicus
1.8.4.2
758
-
purified enzyme
Bos taurus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.4.2
GSH + insulin
-
394817
Bos taurus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + protein disulfide
-
394817
Rattus norvegicus
GSSG + protein-dithiol
-
394817
Rattus norvegicus
?
1.8.4.2
GSH + protein disulfide
-
394817
Bos taurus
GSSG + protein-dithiol
-
394817
Bos taurus
?
Temperature Optimum [░C]
EC Number
Temperature Optimum [░C]
Temperature Optimum Maximum [░C]
Commentary
Organism
1.8.4.2
37
-
assay at
Bos taurus
1.8.4.2
37
-
assay at
Rattus norvegicus
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Bos taurus
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Rattus norvegicus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.8.4.2
additional information
-
additional information
-
Bos taurus
1.8.4.2
additional information
-
additional information
Km in different tissues for GSH and insulin
Rattus norvegicus
1.8.4.2
0.003
0.012
Insulin
enzymes from different rat tissues
Rattus norvegicus
1.8.4.2
0.8
1.7
GSH
enzyme from different rat tissues
Rattus norvegicus
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.8.4.2
-
Bos taurus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.4.2
adipose tissue
-
Rattus norvegicus
-
1.8.4.2
brain
-
Rattus norvegicus
-
1.8.4.2
diaphragm
-
Rattus norvegicus
-
1.8.4.2
heart
-
Rattus norvegicus
-
1.8.4.2
heart
-
Bos taurus
-
1.8.4.2
intestine
-
Rattus norvegicus
-
1.8.4.2
kidney
-
Rattus norvegicus
-
1.8.4.2
kidney
-
Bos taurus
-
1.8.4.2
liver
-
Bos taurus
-
1.8.4.2
liver
-
Rattus norvegicus
-
1.8.4.2
lung
-
Rattus norvegicus
-
1.8.4.2
additional information
relative activities of enzyme in various tissues
Rattus norvegicus
-
1.8.4.2
additional information
relative activities of enzyme in various tissues
Bos taurus
-
1.8.4.2
pancreas
-
Rattus norvegicus
-
1.8.4.2
pancreas
-
Bos taurus
-
1.8.4.2
skeletal muscle
-
Rattus norvegicus
-
1.8.4.2
spleen
-
Rattus norvegicus
-
1.8.4.2
testis
-
Rattus norvegicus
-
1.8.4.2
thymus
-
Rattus norvegicus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
1.8.4.2
additional information
-
-
Bos taurus
1.8.4.2
additional information
-
tissue distribution
Rattus norvegicus
1.8.4.2
758
-
purified enzyme
Bos taurus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.4.2
GSH + insulin
-
394817
Bos taurus
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + protein disulfide
-
394817
Rattus norvegicus
GSSG + protein-dithiol
-
394817
Rattus norvegicus
?
1.8.4.2
GSH + protein disulfide
-
394817
Bos taurus
GSSG + protein-dithiol
-
394817
Bos taurus
?
Temperature Optimum [░C] (protein specific)
EC Number
Temperature Optimum [░C]
Temperature Optimum Maximum [░C]
Commentary
Organism
1.8.4.2
37
-
assay at
Bos taurus
1.8.4.2
37
-
assay at
Rattus norvegicus