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Literature summary extracted from
- Insulin degradation. II. The widespread distribution of glutathione-insulin transhydrogenase in the tissues of the rat (1972), Biochim. Biophys. Acta, 286, 136-145.
Activating Compound
| EC Number | Activating Compound | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.4.2 | phosphatidylethanolamine | activates at low concentration | Rattus norvegicus |  |
| 1.8.4.2 | phosphatidylethanolamine | activates at low concentration | Bos taurus | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.4.2 | additional information | - |
additional information | - |
Bos taurus | |
| 1.8.4.2 | additional information | - |
additional information | Km in different tissues for GSH and insulin | Rattus norvegicus | |
| 1.8.4.2 | 0.003 | 0.012 | Insulin | enzymes from different rat tissues | Rattus norvegicus | |
| 1.8.4.2 | 0.8 | 1.7 | GSH | enzyme from different rat tissues | Rattus norvegicus | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.4.2 | Bos taurus | - |
- |
- |
| 1.8.4.2 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.8.4.2 | - |
Bos taurus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.4.2 | adipose tissue | - |
Rattus norvegicus | - |
| 1.8.4.2 | brain | - |
Rattus norvegicus | - |
| 1.8.4.2 | diaphragm | - |
Rattus norvegicus | - |
| 1.8.4.2 | heart | - |
Rattus norvegicus | - |
| 1.8.4.2 | heart | - |
Bos taurus | - |
| 1.8.4.2 | intestine | - |
Rattus norvegicus | - |
| 1.8.4.2 | kidney | - |
Rattus norvegicus | - |
| 1.8.4.2 | kidney | - |
Bos taurus | - |
| 1.8.4.2 | liver | - |
Rattus norvegicus | - |
| 1.8.4.2 | liver | - |
Bos taurus | - |
| 1.8.4.2 | lung | - |
Rattus norvegicus | - |
| 1.8.4.2 | additional information | relative activities of enzyme in various tissues | Rattus norvegicus | - |
| 1.8.4.2 | additional information | relative activities of enzyme in various tissues | Bos taurus | - |
| 1.8.4.2 | pancreas | - |
Rattus norvegicus | - |
| 1.8.4.2 | pancreas | - |
Bos taurus | - |
| 1.8.4.2 | skeletal muscle | - |
Rattus norvegicus | - |
| 1.8.4.2 | spleen | - |
Rattus norvegicus | - |
| 1.8.4.2 | testis | - |
Rattus norvegicus | - |
| 1.8.4.2 | thymus | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.8.4.2 | additional information | - |
- |
Bos taurus |
| 1.8.4.2 | additional information | - |
tissue distribution | Rattus norvegicus |
| 1.8.4.2 | 758 | - |
purified enzyme | Bos taurus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.4.2 | GSH + insulin | - |
Bos taurus | GSSG + reduced insulin chain A and B | - |
? | |
| 1.8.4.2 | GSH + protein disulfide | - |
Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
| 1.8.4.2 | GSH + protein disulfide | - |
Bos taurus | GSSG + protein-dithiol | - |
? | |
Temperature Optimum [°C]
| EC Number | Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 1.8.4.2 | 37 | - |
assay at | Rattus norvegicus |
| 1.8.4.2 | 37 | - |
assay at | Bos taurus |
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