BRENDA - Enzyme Database

Characterization of a cDNA for human glutathione-insulin transhydrogenase (protein-disulfide isomerase/oxidoreductase)

Morris, J.I.; Varandani, P.T.; Biochim. Biophys. Acta 949, 169-180 (1988)

Data extracted from this reference:

Activating Compound
EC Number
Activating Compound
Commentary
Organism
Structure
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Homo sapiens
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Rattus norvegicus
Cloned(Commentary)
EC Number
Commentary
Organism
1.8.4.2
characterization of cDNA for human glutathione-insulin transhydrogenase, amino acid sequence analysis, 94% homology to rat amino acid sequence
Homo sapiens
1.8.4.2
characterization of cDNA for human glutathione-insulin transhydrogenase, amino acid sequence analysis, 94% homology to rat amino acid sequence
Rattus norvegicus
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.8.4.2
GSH + protein disulfide
Homo sapiens
feedback control via insulin in the liver
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Rattus norvegicus
feedback control via insulin in the liver
GSSG + protein-dithiol
-
-
?
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.8.4.2
Homo sapiens
-
-
-
1.8.4.2
Rattus norvegicus
-
-
-
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.4.2
adipose tissue
-
Rattus norvegicus
-
1.8.4.2
brain
-
Rattus norvegicus
-
1.8.4.2
kidney
-
Homo sapiens
-
1.8.4.2
kidney
-
Rattus norvegicus
-
1.8.4.2
liver
-
Homo sapiens
-
1.8.4.2
liver
-
Rattus norvegicus
-
1.8.4.2
lung
-
Homo sapiens
-
1.8.4.2
lung
-
Rattus norvegicus
-
1.8.4.2
skeletal muscle
-
Rattus norvegicus
-
1.8.4.2
spleen
-
Rattus norvegicus
-
1.8.4.2
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.4.2
GSH + insulin
-
394812
Homo sapiens
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + protein disulfide
-
394812
Homo sapiens
GSSG + protein-dithiol
-
394812
Homo sapiens
?
1.8.4.2
GSH + protein disulfide
-
394812
Rattus norvegicus
GSSG + protein-dithiol
-
394812
Rattus norvegicus
?
1.8.4.2
GSH + protein disulfide
feedback control via insulin in the liver
394812
Homo sapiens
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
feedback control via insulin in the liver
394812
Rattus norvegicus
GSSG + protein-dithiol
-
-
-
?
Activating Compound (protein specific)
EC Number
Activating Compound
Commentary
Organism
Structure
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Homo sapiens
1.8.4.2
phosphatidylethanolamine
activates at low concentration
Rattus norvegicus
Cloned(Commentary) (protein specific)
EC Number
Commentary
Organism
1.8.4.2
characterization of cDNA for human glutathione-insulin transhydrogenase, amino acid sequence analysis, 94% homology to rat amino acid sequence
Homo sapiens
1.8.4.2
characterization of cDNA for human glutathione-insulin transhydrogenase, amino acid sequence analysis, 94% homology to rat amino acid sequence
Rattus norvegicus
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.8.4.2
GSH + protein disulfide
Homo sapiens
feedback control via insulin in the liver
GSSG + protein-dithiol
-
-
?
1.8.4.2
GSH + protein disulfide
Rattus norvegicus
feedback control via insulin in the liver
GSSG + protein-dithiol
-
-
?
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.4.2
adipose tissue
-
Rattus norvegicus
-
1.8.4.2
brain
-
Rattus norvegicus
-
1.8.4.2
kidney
-
Homo sapiens
-
1.8.4.2
kidney
-
Rattus norvegicus
-
1.8.4.2
liver
-
Homo sapiens
-
1.8.4.2
liver
-
Rattus norvegicus
-
1.8.4.2
lung
-
Homo sapiens
-
1.8.4.2
lung
-
Rattus norvegicus
-
1.8.4.2
skeletal muscle
-
Rattus norvegicus
-
1.8.4.2
spleen
-
Rattus norvegicus
-
1.8.4.2
testis
-
Rattus norvegicus
-
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.4.2
GSH + insulin
-
394812
Homo sapiens
GSSG + reduced insulin chain A and B
-
-
-
-
1.8.4.2
GSH + protein disulfide
-
394812
Homo sapiens
GSSG + protein-dithiol
-
394812
Homo sapiens
?
1.8.4.2
GSH + protein disulfide
-
394812
Rattus norvegicus
GSSG + protein-dithiol
-
394812
Rattus norvegicus
?
1.8.4.2
GSH + protein disulfide
feedback control via insulin in the liver
394812
Homo sapiens
GSSG + protein-dithiol
-
-
-
?
1.8.4.2
GSH + protein disulfide
feedback control via insulin in the liver
394812
Rattus norvegicus
GSSG + protein-dithiol
-
-
-
?