EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.8.4.2 | Chelating agents | e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation | Mus musculus | |
1.8.4.2 | Chelating agents | e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation | Homo sapiens | |
1.8.4.2 | Chelating agents | e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation | Rattus norvegicus | |
1.8.4.2 | Chelating agents | e.g. EDTA, EGTA, 8-hydroxyquinoline, 1,10-phenanthroline, activation | Bos taurus | |
1.8.4.2 | EDTA | and other chelating agents activate | Mus musculus | |
1.8.4.2 | EDTA | and other chelating agents activate | Homo sapiens | |
1.8.4.2 | EDTA | and other chelating agents activate | Rattus norvegicus | |
1.8.4.2 | EDTA | and other chelating agents activate | Bos taurus | |
1.8.4.2 | additional information | overview | Mus musculus | |
1.8.4.2 | additional information | overview | Homo sapiens | |
1.8.4.2 | additional information | overview | Rattus norvegicus | |
1.8.4.2 | additional information | overview | Bos taurus | |
1.8.4.2 | phosphatidylethanolamine | activates at low concentration | Mus musculus | |
1.8.4.2 | phosphatidylethanolamine | activates at low concentration | Homo sapiens | |
1.8.4.2 | phosphatidylethanolamine | activates at low concentration | Rattus norvegicus | |
1.8.4.2 | phosphatidylethanolamine | activates at low concentration | Bos taurus |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.8.4.2 | Aprotinin | - |
Bos taurus | |
1.8.4.2 | Aprotinin | - |
Homo sapiens | |
1.8.4.2 | Aprotinin | - |
Mus musculus | |
1.8.4.2 | Aprotinin | - |
Rattus norvegicus | |
1.8.4.2 | bacitracin | - |
Bos taurus | |
1.8.4.2 | bacitracin | - |
Homo sapiens | |
1.8.4.2 | bacitracin | - |
Mus musculus | |
1.8.4.2 | bacitracin | - |
Rattus norvegicus | |
1.8.4.2 | Ca2+ | slight | Bos taurus | |
1.8.4.2 | Ca2+ | slight | Homo sapiens | |
1.8.4.2 | Ca2+ | slight | Mus musculus | |
1.8.4.2 | Ca2+ | slight | Rattus norvegicus | |
1.8.4.2 | Cu2+ | - |
Bos taurus | |
1.8.4.2 | Cu2+ | - |
Homo sapiens | |
1.8.4.2 | Cu2+ | - |
Mus musculus | |
1.8.4.2 | Cu2+ | - |
Rattus norvegicus | |
1.8.4.2 | Hg2+ | - |
Bos taurus | |
1.8.4.2 | Hg2+ | - |
Homo sapiens | |
1.8.4.2 | Hg2+ | - |
Mus musculus | |
1.8.4.2 | Hg2+ | - |
Rattus norvegicus | |
1.8.4.2 | lysolecithin | - |
Bos taurus | |
1.8.4.2 | lysolecithin | - |
Homo sapiens | |
1.8.4.2 | lysolecithin | - |
Mus musculus | |
1.8.4.2 | lysolecithin | - |
Rattus norvegicus | |
1.8.4.2 | additional information | overview | Bos taurus | |
1.8.4.2 | additional information | overview | Homo sapiens | |
1.8.4.2 | additional information | overview | Mus musculus | |
1.8.4.2 | additional information | overview | Rattus norvegicus | |
1.8.4.2 | Ni2+ | slight | Bos taurus | |
1.8.4.2 | Ni2+ | slight | Homo sapiens | |
1.8.4.2 | Ni2+ | slight | Mus musculus | |
1.8.4.2 | Ni2+ | slight | Rattus norvegicus | |
1.8.4.2 | phosphatidic acid | - |
Bos taurus | |
1.8.4.2 | phosphatidic acid | - |
Homo sapiens | |
1.8.4.2 | phosphatidic acid | - |
Mus musculus | |
1.8.4.2 | phosphatidic acid | - |
Rattus norvegicus | |
1.8.4.2 | Se2+ | - |
Bos taurus | |
1.8.4.2 | Se2+ | - |
Homo sapiens | |
1.8.4.2 | Se2+ | - |
Mus musculus | |
1.8.4.2 | Se2+ | - |
Rattus norvegicus | |
1.8.4.2 | Zn2+ | - |
Bos taurus | |
1.8.4.2 | Zn2+ | - |
Homo sapiens | |
1.8.4.2 | Zn2+ | - |
Mus musculus | |
1.8.4.2 | Zn2+ | - |
Rattus norvegicus |
EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.8.4.2 | additional information | - |
additional information | - |
Mus musculus | |
1.8.4.2 | additional information | - |
additional information | - |
Homo sapiens | |
1.8.4.2 | additional information | - |
additional information | - |
Rattus norvegicus | |
1.8.4.2 | additional information | - |
additional information | - |
Bos taurus | |
1.8.4.2 | 0.01 | - |
Insulin | - |
Mus musculus | |
1.8.4.2 | 0.01 | - |
Insulin | - |
Homo sapiens | |
1.8.4.2 | 0.01 | - |
Insulin | - |
Rattus norvegicus | |
1.8.4.2 | 0.01 | - |
Insulin | - |
Bos taurus |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.8.4.2 | endoplasmic reticulum | - |
Rattus norvegicus | 5783 | - |
1.8.4.2 | membrane | bound to | Rattus norvegicus | 16020 | - |
1.8.4.2 | microsome | majority of the enzyme located at | Rattus norvegicus | - |
- |
1.8.4.2 | microsome | weakly bound on cisternal surface of microsomes via phospholipids | Rattus norvegicus | - |
- |
1.8.4.2 | secretory granule | of alpha and beta cells of islets of Langerhans | Rattus norvegicus | 30141 | - |
1.8.4.2 | zymogen granule | of acinar cells | Rattus norvegicus | 42588 | - |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.8.4.2 | additional information | - |
3 molecular forms: MW 56000 is the major form, MW 51000 is active and only present in spleen, possibly a proteolytic product of 56000 MW protein, MW 67000 is possibly a precursor of 56000 MW protein | Rattus norvegicus |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.4.2 | GSH + protein disulfide | Mus musculus | physiological function | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Homo sapiens | physiological function | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Rattus norvegicus | physiological function | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Bos taurus | physiological function | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Mus musculus | reductive degradation and assembly of proteins | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Homo sapiens | reductive degradation and assembly of proteins | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Rattus norvegicus | reductive degradation and assembly of proteins | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Bos taurus | reductive degradation and assembly of proteins | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Mus musculus | modulation of enzymatic activity from latent to active form and vice versa | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Homo sapiens | modulation of enzymatic activity from latent to active form and vice versa | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Rattus norvegicus | modulation of enzymatic activity from latent to active form and vice versa | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Bos taurus | modulation of enzymatic activity from latent to active form and vice versa | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Mus musculus | feedback control via insulin in the liver | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Homo sapiens | feedback control via insulin in the liver | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Rattus norvegicus | feedback control via insulin in the liver | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | Bos taurus | feedback control via insulin in the liver | GSSG + protein-dithiol | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.4.2 | Bos taurus | - |
- |
- |
1.8.4.2 | Homo sapiens | - |
- |
- |
1.8.4.2 | Mus musculus | - |
- |
- |
1.8.4.2 | Rattus norvegicus | - |
- |
- |
EC Number | Posttranslational Modification | Comment | Organism |
---|---|---|---|
1.8.4.2 | phospholipoprotein | - |
Rattus norvegicus |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.8.4.2 | adipose tissue | - |
Rattus norvegicus | - |
1.8.4.2 | brain | - |
Rattus norvegicus | - |
1.8.4.2 | diaphragm | - |
Rattus norvegicus | - |
1.8.4.2 | erythrocyte | - |
Homo sapiens | - |
1.8.4.2 | heart | - |
Mus musculus | - |
1.8.4.2 | heart | - |
Homo sapiens | - |
1.8.4.2 | heart | - |
Rattus norvegicus | - |
1.8.4.2 | heart | - |
Bos taurus | - |
1.8.4.2 | intestine | - |
Rattus norvegicus | - |
1.8.4.2 | kidney | - |
Mus musculus | - |
1.8.4.2 | kidney | - |
Homo sapiens | - |
1.8.4.2 | kidney | - |
Rattus norvegicus | - |
1.8.4.2 | kidney | - |
Bos taurus | - |
1.8.4.2 | lens | - |
Rattus norvegicus | - |
1.8.4.2 | leukocyte | - |
Homo sapiens | - |
1.8.4.2 | liver | - |
Mus musculus | - |
1.8.4.2 | liver | - |
Homo sapiens | - |
1.8.4.2 | liver | - |
Rattus norvegicus | - |
1.8.4.2 | liver | - |
Bos taurus | - |
1.8.4.2 | lung | - |
Homo sapiens | - |
1.8.4.2 | lung | - |
Rattus norvegicus | - |
1.8.4.2 | additional information | - |
Mus musculus | - |
1.8.4.2 | additional information | - |
Rattus norvegicus | - |
1.8.4.2 | additional information | - |
Bos taurus | - |
1.8.4.2 | additional information | higher activity in mononuclear cells than in polymorphonuclear cells | Homo sapiens | - |
1.8.4.2 | pancreas | - |
Mus musculus | - |
1.8.4.2 | pancreas | - |
Homo sapiens | - |
1.8.4.2 | pancreas | - |
Rattus norvegicus | - |
1.8.4.2 | pancreas | - |
Bos taurus | - |
1.8.4.2 | placenta | - |
Rattus norvegicus | - |
1.8.4.2 | retina | - |
Rattus norvegicus | - |
1.8.4.2 | skeletal muscle | - |
Rattus norvegicus | - |
1.8.4.2 | spleen | - |
Rattus norvegicus | - |
1.8.4.2 | testis | - |
Rattus norvegicus | - |
1.8.4.2 | thymus | - |
Rattus norvegicus | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.8.4.2 | additional information | - |
assay methods | Mus musculus |
1.8.4.2 | additional information | - |
assay methods | Homo sapiens |
1.8.4.2 | additional information | - |
assay methods | Rattus norvegicus |
1.8.4.2 | additional information | - |
assay methods | Bos taurus |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.4.2 | 2,3-dimercaptopropanol + protein disulfide | - |
Mus musculus | 2,3-dimercaptopropanol disulfide + protein-dithiol | - |
? | |
1.8.4.2 | 2,3-dimercaptopropanol + protein disulfide | - |
Homo sapiens | 2,3-dimercaptopropanol disulfide + protein-dithiol | - |
? | |
1.8.4.2 | 2,3-dimercaptopropanol + protein disulfide | - |
Rattus norvegicus | 2,3-dimercaptopropanol disulfide + protein-dithiol | - |
? | |
1.8.4.2 | 2,3-dimercaptopropanol + protein disulfide | - |
Bos taurus | 2,3-dimercaptopropanol disulfide + protein-dithiol | - |
? | |
1.8.4.2 | cysteamine + protein disulfide | - |
Mus musculus | ? | - |
? | |
1.8.4.2 | cysteamine + protein disulfide | - |
Homo sapiens | ? | - |
? | |
1.8.4.2 | cysteamine + protein disulfide | - |
Rattus norvegicus | ? | - |
? | |
1.8.4.2 | cysteamine + protein disulfide | - |
Bos taurus | ? | - |
? | |
1.8.4.2 | dihydrolipoic acid + protein disulfide | - |
Mus musculus | ? | - |
? | |
1.8.4.2 | dihydrolipoic acid + protein disulfide | - |
Homo sapiens | ? | - |
? | |
1.8.4.2 | dihydrolipoic acid + protein disulfide | - |
Rattus norvegicus | ? | - |
? | |
1.8.4.2 | dihydrolipoic acid + protein disulfide | - |
Bos taurus | ? | - |
? | |
1.8.4.2 | GSH + insulin | proinsulin | Mus musculus | GSSG + reduced insulin chain A and B | - |
? | |
1.8.4.2 | GSH + insulin | proinsulin | Homo sapiens | GSSG + reduced insulin chain A and B | - |
? | |
1.8.4.2 | GSH + insulin | proinsulin | Rattus norvegicus | GSSG + reduced insulin chain A and B | - |
? | |
1.8.4.2 | GSH + insulin | proinsulin | Bos taurus | GSSG + reduced insulin chain A and B | - |
? | |
1.8.4.2 | GSH + oxytoxin | - |
Mus musculus | ? | - |
? | |
1.8.4.2 | GSH + oxytoxin | - |
Homo sapiens | ? | - |
? | |
1.8.4.2 | GSH + oxytoxin | - |
Rattus norvegicus | ? | - |
? | |
1.8.4.2 | GSH + oxytoxin | - |
Bos taurus | ? | - |
? | |
1.8.4.2 | GSH + protein disulfide | - |
Mus musculus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | - |
Homo sapiens | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | - |
Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | - |
Bos taurus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | physiological function | Mus musculus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | physiological function | Homo sapiens | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | physiological function | Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | physiological function | Bos taurus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | reductive degradation and assembly of proteins | Mus musculus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | reductive degradation and assembly of proteins | Homo sapiens | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | reductive degradation and assembly of proteins | Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | reductive degradation and assembly of proteins | Bos taurus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | modulation of enzymatic activity from latent to active form and vice versa | Mus musculus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | modulation of enzymatic activity from latent to active form and vice versa | Homo sapiens | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | modulation of enzymatic activity from latent to active form and vice versa | Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | modulation of enzymatic activity from latent to active form and vice versa | Bos taurus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | feedback control via insulin in the liver | Mus musculus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | feedback control via insulin in the liver | Homo sapiens | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | feedback control via insulin in the liver | Rattus norvegicus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + protein disulfide | feedback control via insulin in the liver | Bos taurus | GSSG + protein-dithiol | - |
? | |
1.8.4.2 | GSH + vasopressin | - |
Mus musculus | ? | - |
? | |
1.8.4.2 | GSH + vasopressin | - |
Homo sapiens | ? | - |
? | |
1.8.4.2 | GSH + vasopressin | - |
Rattus norvegicus | ? | - |
? | |
1.8.4.2 | GSH + vasopressin | - |
Bos taurus | ? | - |
? | |
1.8.4.2 | additional information | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Mus musculus | ? | - |
? | |
1.8.4.2 | additional information | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Homo sapiens | ? | - |
? | |
1.8.4.2 | additional information | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Rattus norvegicus | ? | - |
? | |
1.8.4.2 | additional information | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Bos taurus | ? | - |
? | |
1.8.4.2 | additional information | immunoglobulin IgM and IgG | Mus musculus | ? | - |
? | |
1.8.4.2 | additional information | immunoglobulin IgM and IgG | Homo sapiens | ? | - |
? | |
1.8.4.2 | additional information | immunoglobulin IgM and IgG | Rattus norvegicus | ? | - |
? | |
1.8.4.2 | additional information | immunoglobulin IgM and IgG | Bos taurus | ? | - |
? | |
1.8.4.2 | additional information | scrambled lysozyme | Mus musculus | ? | - |
? | |
1.8.4.2 | additional information | scrambled lysozyme | Homo sapiens | ? | - |
? | |
1.8.4.2 | additional information | scrambled lysozyme | Rattus norvegicus | ? | - |
? | |
1.8.4.2 | additional information | scrambled lysozyme | Bos taurus | ? | - |
? | |
1.8.4.2 | additional information | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Mus musculus | ? | - |
? | |
1.8.4.2 | additional information | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Homo sapiens | ? | - |
? | |
1.8.4.2 | additional information | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Rattus norvegicus | ? | - |
? | |
1.8.4.2 | additional information | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Bos taurus | ? | - |
? | |
1.8.4.2 | additional information | enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease | Mus musculus | ? | - |
? | |
1.8.4.2 | additional information | enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease | Homo sapiens | ? | - |
? | |
1.8.4.2 | additional information | enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease | Rattus norvegicus | ? | - |
? | |
1.8.4.2 | additional information | enzyme also catalyzes reactivation and folding of protein containing incorrectly paired disulfide bond, e.g.: scrambled ribonuclease | Bos taurus | ? | - |
? |
EC Number | Synonyms | Comment | Organism |
---|---|---|---|
1.8.4.2 | GIT | - |
Mus musculus |
1.8.4.2 | GIT | - |
Homo sapiens |
1.8.4.2 | GIT | - |
Rattus norvegicus |
1.8.4.2 | GIT | - |
Bos taurus |
1.8.4.2 | More | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Mus musculus |
1.8.4.2 | More | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Homo sapiens |
1.8.4.2 | More | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Rattus norvegicus |
1.8.4.2 | More | the two activities, cleavage and formation of protein-disulfide bonds, present alternate activities of the same enzyme | Bos taurus |
1.8.4.2 | More | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Mus musculus |
1.8.4.2 | More | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Homo sapiens |
1.8.4.2 | More | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Rattus norvegicus |
1.8.4.2 | More | thiol:protein-disulfide oxidoreductase EC 1.8.4.2 and thiol:protein-disulfide isomerase EC 5.3.4.1 are immunological identical | Bos taurus |