Literature summary extracted from

Bonnet, B.; Soullez, D.; Davioud-Charvet, E.; Landry, V.; Horvath, D.; Sergheraert, C.
New spermine and spermidine derivatives as potent inhibitors of Trypanosoma cruzi trypanothione reductase (1997), Bioorg. Med. Chem., 5, 1249-1256.

Inhibitors

EC Number	Inhibitors	Comment	Organism	Structure
1.8.1.12	clomipramine	-	Trypanosoma cruzi
1.8.1.12	phenothiazines	-	Trypanosoma cruzi
1.8.1.12	spermidine derivatives	derivatives of 2-amino-diphenylsulfide + phenothiazine	Trypanosoma cruzi
1.8.1.12	spermine derivatives	derivatives of 2-amino-diphenylsulfide + phenothiazine	Trypanosoma cruzi

Organism

EC Number	Organism	UniProt	Comment	Textmining
1.8.1.12	Trypanosoma cruzi	-	-	-

Temperature Optimum [°C]

EC Number	Temperature Optimum [°C]	Temperature Optimum Maximum [°C]	Comment	Organism
1.8.1.12	21	-	assay at	Trypanosoma cruzi

pH Optimum

EC Number	pH Optimum Minimum	pH Optimum Maximum	Comment	Organism
1.8.1.12	7.25	-	assay at	Trypanosoma cruzi

Cofactor

EC Number	Cofactor	Comment	Organism	Structure
1.8.1.12	FAD	-	Trypanosoma cruzi
1.8.1.12	NADPH	-	Trypanosoma cruzi

Ki Value [mM]

EC Number	Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
1.8.1.12	additional information	-	additional information	derivatives of 2-amino-diphenylsulfide + phenothiazine	Trypanosoma cruzi
1.8.1.12	0.01	-	phenothiazines	-	Trypanosoma cruzi

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Release 2023.1 (January 2023)