EC Number | Activating Compound | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.7 | cysteine | redox active disulfide at the catalytic site | Homo sapiens | |
1.8.1.12 | additional information | activity is dependent on a redox-active cysteine at the active centre | Crithidia fasciculata | |
1.8.1.12 | additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma cruzi | |
1.8.1.12 | additional information | activity is dependent on a redox-active cysteine at the active centre | Trypanosoma congolense |
EC Number | Application | Comment | Organism |
---|---|---|---|
1.8.1.7 | medicine | mimicking of favism by inhibiting the enzyme with specific inhibitors to protect against malaria | Homo sapiens |
1.8.1.7 | medicine | potential target of antimalarial and cytostatic agents | Homo sapiens |
1.8.1.12 | medicine | potential target for drug design against trypanosomiasis | Crithidia fasciculata |
1.8.1.12 | medicine | potential target for drug design against trypanosomiasis | Trypanosoma cruzi |
1.8.1.12 | medicine | potential target for drug design against trypanosomiasis | Trypanosoma congolense |
EC Number | Crystallization (Comment) | Organism |
---|---|---|
1.8.1.7 | - |
Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.7 | carmustine | irreversible inhibito of enzyme in reduced state | Homo sapiens | |
1.8.1.7 | NADPH | slow inactivation in vitro due to inter- or intramolecular disulfide formation | Homo sapiens | |
1.8.1.12 | nifurtimox | weak inhibitor | Trypanosoma cruzi |
EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|---|
1.8.1.7 | 100000 | - |
- |
Homo sapiens |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.8.1.7 | Homo sapiens | - |
- |
- |
1.8.1.12 | Crithidia fasciculata | - |
insect-parasitic trypanosomatid | - |
1.8.1.12 | Trypanosoma congolense | - |
- |
- |
1.8.1.12 | Trypanosoma cruzi | - |
- |
- |
EC Number | Reaction | Comment | Organism | Reaction ID |
---|---|---|---|---|
1.8.1.7 | 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ | mechanism | Homo sapiens | |
1.8.1.7 | 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ | member of pyridine-nucleotide disulfide oxidoreductase family of flavoenzymes | Homo sapiens | |
1.8.1.7 | 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ | catalytic cycle | Homo sapiens | |
1.8.1.7 | 2 glutathione + NADP+ = glutathione disulfide + NADPH + H+ | substrate and cofactor binding site, three-dimensional structure | Homo sapiens | |
1.8.1.12 | trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | mechanistic scheme for NAD(P)H:disulfide oxidoreductases | Crithidia fasciculata | |
1.8.1.12 | trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | mechanistic scheme for NAD(P)H:disulfide oxidoreductases | Trypanosoma cruzi | |
1.8.1.12 | trypanothione + NADP+ = trypanothione disulfide + NADPH + H+ | mechanistic scheme for NAD(P)H:disulfide oxidoreductases | Trypanosoma congolense |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.8.1.7 | GSSG + NADPH | - |
Homo sapiens | glutathione + NADP+ | - |
r | |
1.8.1.12 | trypanothione disulfide + NADPH | - |
Crithidia fasciculata | trypanothione + NADP+ | - |
r | |
1.8.1.12 | trypanothione disulfide + NADPH | - |
Trypanosoma cruzi | trypanothione + NADP+ | - |
r | |
1.8.1.12 | trypanothione disulfide + NADPH | - |
Trypanosoma congolense | trypanothione + NADP+ | - |
r |
EC Number | Subunits | Comment | Organism |
---|---|---|---|
1.8.1.12 | dimer | - |
Crithidia fasciculata |
1.8.1.12 | dimer | - |
Trypanosoma cruzi |
1.8.1.12 | dimer | - |
Trypanosoma congolense |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.8.1.7 | FAD | FAD enzyme | Homo sapiens | |
1.8.1.7 | additional information | as malaria brings riboflavin deficiency, in effection regions a large portion of enzymes miss FAD, but are as well active | Homo sapiens | |
1.8.1.7 | NADPH | can utilize both NADPH and NADH, more active with NADPH | Homo sapiens | |
1.8.1.12 | FAD | - |
Crithidia fasciculata | |
1.8.1.12 | FAD | - |
Trypanosoma cruzi | |
1.8.1.12 | FAD | - |
Trypanosoma congolense | |
1.8.1.12 | NADPH | - |
Crithidia fasciculata | |
1.8.1.12 | NADPH | - |
Trypanosoma cruzi | |
1.8.1.12 | NADPH | - |
Trypanosoma congolense |
EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|---|
1.8.1.12 | 0.15 | - |
nifurtimox | - |
Trypanosoma cruzi |