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Literature summary extracted from
- Human erythrocyte glutathione reductase. I. Purification and properties (1976), Biochim. Biophys. Acta, 445, 309-323.
Crystallization (Commentary)
| EC Number | Crystallization (Comment) | Organism |
|---|---|---|
| 1.8.1.7 | - |
Homo sapiens |
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | NADH-X | - |
Homo sapiens |  |
| 1.8.1.7 | NADP+ | - |
Homo sapiens | |
| 1.8.1.7 | NADPH | derivatives | Homo sapiens | |
| 1.8.1.7 | NADPH-X | - |
Homo sapiens | |
KM Value [mM]
| EC Number | KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.7 | 0.009 | - |
NADPH | pH 6.8 | Homo sapiens | |
| 1.8.1.7 | 0.25 | - |
NADH | pH 6.05 | Homo sapiens | |
| 1.8.1.7 | 0.67 | - |
NADH | pH 6.8 | Homo sapiens | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | Homo sapiens | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.8.1.7 | - |
Homo sapiens |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.8.1.7 | erythrocyte | - |
Homo sapiens | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 34 | - |
purified enzyme, with NADH | Homo sapiens |
| 1.8.1.7 | 207 | - |
purified protein, with NADPH | Homo sapiens |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.8.1.7 | glutathione disulfide + NADH + H+ | - |
Homo sapiens | glutathione + NAD+ | - |
? | |
| 1.8.1.7 | GSSG + NADPH | - |
Homo sapiens | glutathione + NADP+ | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.8.1.7 | 6 | - |
NADH + GSSG | Homo sapiens |
| 1.8.1.7 | 6.8 | - |
NADPH + GSSG | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.8.1.7 | FAD | FAD enzyme | Homo sapiens | |
| 1.8.1.7 | NADH | a single enzyme uses both NADPH and NADH as hydrogen donors | Homo sapiens | |
| 1.8.1.7 | NADPH | a single enzyme uses both NADPH and NADH as hydrogen donors | Homo sapiens | |
Ki Value [mM]
| EC Number | Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|---|
| 1.8.1.7 | 0.0072 | - |
NADP+ | with NADH at pH 6.8 | Homo sapiens | |
| 1.8.1.7 | 0.018 | - |
NADP+ | with NADH at pH 6.05 | Homo sapiens | |
| 1.8.1.7 | 0.022 | - |
NADPH-X | derivative, pH 6.8, with NADPH | Homo sapiens | |
| 1.8.1.7 | 0.055 | - |
NADP+ | with NADPH at pH 6.8 | Homo sapiens | |
| 1.8.1.7 | 0.54 | - |
NADH-X | derivative, pH 6.8, with NADH | Homo sapiens | |
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