BRENDA - Enzyme Database show

Glutathione reductase

Schirmer, R.H.; Krauth-Siegel, R.L.; Schulz, G.E.; Coenzymes and cofactors, Glutathione, Chem. Biochem. Med. Aspects Pt. A (Dolphin D, Poulson R, Avromonic O, eds. ) John Wiley & Sons, New York 3, 553-596 (1989)
No PubMed abstract available

Data extracted from this reference:

Crystallization (Commentary)
EC Number
Crystallization
Organism
1.8.1.7
molecular asymmetry of crystals from deionized water and from 2 M ammonium sulfate, exact 2fold molecular axis in the dimer, form A-D, three-dimensional structure
Homo sapiens
1.8.1.7
trigonal crystals, high internal symmetry
Escherichia coli
General Stability
EC Number
General Stability
Organism
1.8.1.7
concentrated solution, stable for years
Mus musculus
1.8.1.7
concentrated solution, stable for years
Escherichia coli
1.8.1.7
concentrated solution, stable for years
Homo sapiens
1.8.1.7
concentrated solution, stable for years
Rattus norvegicus
1.8.1.7
concentrated solution, stable for years
Sus scrofa
1.8.1.7
concentrated solution, stable for years
Saccharomyces cerevisiae
1.8.1.7
concentrated solution, stable for years
Bos taurus
1.8.1.7
concentrated solution, stable for years
Oryctolagus cuniculus
1.8.1.7
concentrated solution, stable for years
Penicillium chrysogenum
1.8.1.7
concentrated solution, stable for years
Spinacia oleracea
1.8.1.7
concentrated solution, stable for years
Meriones unguiculatus
1.8.1.7
concentrated solution, stable for years
Allochromatium vinosum
1.8.1.7
concentrated solution, stable for years
Scombridae
1.8.1.7
concentrated solution, stable for years
Plasmodium vinckei
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Mus musculus
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Escherichia coli
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Homo sapiens
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Rattus norvegicus
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Sus scrofa
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Saccharomyces cerevisiae
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Bos taurus
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Oryctolagus cuniculus
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Penicillium chrysogenum
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Spinacia oleracea
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Meriones unguiculatus
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Allochromatium vinosum
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Scombridae
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Plasmodium vinckei
1.8.1.7
repeated freezing and thawing, inactivation
Mus musculus
1.8.1.7
repeated freezing and thawing, inactivation
Escherichia coli
1.8.1.7
repeated freezing and thawing, inactivation
Homo sapiens
1.8.1.7
repeated freezing and thawing, inactivation
Rattus norvegicus
1.8.1.7
repeated freezing and thawing, inactivation
Sus scrofa
1.8.1.7
repeated freezing and thawing, inactivation
Saccharomyces cerevisiae
1.8.1.7
repeated freezing and thawing, inactivation
Bos taurus
1.8.1.7
repeated freezing and thawing, inactivation
Oryctolagus cuniculus
1.8.1.7
repeated freezing and thawing, inactivation
Penicillium chrysogenum
1.8.1.7
repeated freezing and thawing, inactivation
Spinacia oleracea
1.8.1.7
repeated freezing and thawing, inactivation
Meriones unguiculatus
1.8.1.7
repeated freezing and thawing, inactivation
Allochromatium vinosum
1.8.1.7
repeated freezing and thawing, inactivation
Scombridae
1.8.1.7
repeated freezing and thawing, inactivation
Plasmodium vinckei
Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.8.1.7
1,2-Cyclohexanedione
-
Homo sapiens
1.8.1.7
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
Homo sapiens
1.8.1.7
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
Rattus norvegicus
1.8.1.7
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
Saccharomyces cerevisiae
1.8.1.7
1-(2-Chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea
-
Homo sapiens
1.8.1.7
1-chloro-2,4-dinitrobenzene
reversible
Homo sapiens
1.8.1.7
1-Fluoro-2,4-dinitrobenzene
reversible
Saccharomyces cerevisiae
1.8.1.7
2,3-Butanedione
-
Homo sapiens
1.8.1.7
2,4,6-Trinitrobenzenesulfonate
reversible
Bos taurus
1.8.1.7
2-Chloroethylisocyanate
-
Saccharomyces cerevisiae
1.8.1.7
arsenite
-
Homo sapiens
1.8.1.7
arsenite
-
Litomosoides carinii
1.8.1.7
arsenite
-
Rattus norvegicus
1.8.1.7
arsenite
-
Saccharomyces cerevisiae
1.8.1.7
Benzylselenosulfate
-
Rattus norvegicus
1.8.1.7
Cd2+
-
Homo sapiens
1.8.1.7
Cd2+
-
Scombridae
1.8.1.7
chromate
-
Allochromatium vinosum
1.8.1.7
chromate
-
Bos taurus
1.8.1.7
chromate
-
Escherichia coli
1.8.1.7
chromate
-
Homo sapiens
1.8.1.7
chromate
-
Meriones unguiculatus
1.8.1.7
chromate
-
Mus musculus
1.8.1.7
chromate
-
Oryctolagus cuniculus
1.8.1.7
chromate
-
Penicillium chrysogenum
1.8.1.7
chromate
-
Plasmodium vinckei
1.8.1.7
chromate
probably irreversible
Rattus norvegicus
1.8.1.7
chromate
-
Saccharomyces cerevisiae
1.8.1.7
chromate
-
Scombridae
1.8.1.7
chromate
-
Spinacia oleracea
1.8.1.7
chromate
-
Sus scrofa
1.8.1.7
Cu2+
-
Saccharomyces cerevisiae
1.8.1.7
Cu2+
-
Allochromatium vinosum
1.8.1.7
Dinitrosated isomers of N,N'-bis[N(2-chloroethyl)-N-carbonyl]cysteamine
-
Rattus norvegicus
1.8.1.7
Haemin
mediates covalent cross-linking and degradation of the enzyme
Saccharomyces cerevisiae
1.8.1.7
Hg2+
-
Rattus norvegicus
1.8.1.7
Iodine
-
Saccharomyces cerevisiae
1.8.1.7
iodoacetamide
-
Homo sapiens
1.8.1.7
iodoacetamide
-
Saccharomyces cerevisiae
1.8.1.7
Melarsen oxide
-
Homo sapiens
1.8.1.7
Melarsen oxide
-
Litomosoides carinii
1.8.1.7
additional information
regulation by inactivation in vivo, e.g. by disulfide bridging
Homo sapiens
1.8.1.7
additional information
regulation by inactivation in vivo, e.g. by disulfide bridging
Mus musculus
1.8.1.7
additional information
regulation by inactivation in vivo, e.g. by disulfide bridging
Saccharomyces cerevisiae
1.8.1.7
N,N'-bis(trans-4-hydroxycyclohexyl)-N'-nitrosourea
-
Rattus norvegicus
1.8.1.7
N-Alkylmaleimide
-
Saccharomyces cerevisiae
1.8.1.7
nifurtimox
-
Homo sapiens
1.8.1.7
nifurtimox
-
Rattus norvegicus
1.8.1.7
Nitrofurantoin
-
Allochromatium vinosum
1.8.1.7
Nitrofurantoin
-
Bos taurus
1.8.1.7
Nitrofurantoin
-
Escherichia coli
1.8.1.7
Nitrofurantoin
-
Homo sapiens
1.8.1.7
Nitrofurantoin
-
Meriones unguiculatus
1.8.1.7
Nitrofurantoin
-
Mus musculus
1.8.1.7
Nitrofurantoin
-
Oryctolagus cuniculus
1.8.1.7
Nitrofurantoin
-
Penicillium chrysogenum
1.8.1.7
Nitrofurantoin
-
Plasmodium vinckei
1.8.1.7
Nitrofurantoin
-
Rattus norvegicus
1.8.1.7
Nitrofurantoin
-
Saccharomyces cerevisiae
1.8.1.7
Nitrofurantoin
-
Scombridae
1.8.1.7
Nitrofurantoin
-
Spinacia oleracea
1.8.1.7
Nitrofurantoin
-
Sus scrofa
1.8.1.7
Nitrogen mustard
-
Homo sapiens
1.8.1.7
p-hydroxymercuribenzoate
-
Escherichia coli
1.8.1.7
p-hydroxymercuribenzoate
-
Oryctolagus cuniculus
1.8.1.7
p-hydroxymercuribenzoate
-
Rattus norvegicus
1.8.1.7
p-hydroxymercuribenzoate
-
Meriones unguiculatus
1.8.1.7
p-hydroxymercuribenzoate
-
Allochromatium vinosum
1.8.1.7
Phenylarsonous acid
-
Saccharomyces cerevisiae
1.8.1.7
Phenylglyoxal
-
Homo sapiens
1.8.1.7
Phenylglyoxal
-
Saccharomyces cerevisiae
1.8.1.7
S-(2,4-dinitrophenyl)-glutathione
-
Homo sapiens
1.8.1.7
Zn2+
-
Homo sapiens
1.8.1.7
Zn2+
-
Rattus norvegicus
1.8.1.7
Zn2+
-
Spinacia oleracea
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.8.1.7
0.008
-
NADPH
-
Homo sapiens
1.8.1.7
0.008
-
NADPH
-
Oryctolagus cuniculus
1.8.1.7
0.008
-
NADPH
-
Rattus norvegicus
1.8.1.7
0.065
-
GSSG
-
Homo sapiens
1.8.1.7
0.25
-
glutathione-S-sulfonate
-
Saccharomyces cerevisiae
1.8.1.7
1
-
mixed disulfide of coenzyme A and glutathione
-
Homo sapiens
1.8.1.7
7
-
GSSG
-
Allochromatium vinosum
1.8.1.7
11.6
-
bis-N,N'-(gamma-glutamylcystine)
-
Saccharomyces cerevisiae
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.8.1.7
chloroplast
cytoplasm-like spaces of chloroplasts
Spinacia oleracea
9507
-
1.8.1.7
cytoplasm
-
Bos taurus
5737
-
1.8.1.7
cytoplasm
-
Rattus norvegicus
5737
-
1.8.1.7
mitochondrion
cytoplasm-like spaces of mitochondria
Rattus norvegicus
5739
-
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.8.1.7
52500
-
2 * 52500
Homo sapiens
Natural Substrates/ Products (Substrates)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.8.1.7
GSSG + NADPH
Rattus norvegicus
-
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Mus musculus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Escherichia coli
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Homo sapiens
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Sus scrofa
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Saccharomyces cerevisiae
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Bos taurus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Oryctolagus cuniculus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Penicillium chrysogenum
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Spinacia oleracea
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Meriones unguiculatus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Allochromatium vinosum
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Scombridae
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Plasmodium vinckei
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Bufo bufo
high GSSG level in dormant stage
glutathione + NADP+
-
-
?
1.8.1.7
additional information
Homo sapiens
glutathione redox cycle
?
-
-
-
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.8.1.7
Allochromatium vinosum
-
-
-
1.8.1.7
Bos taurus
-
-
-
1.8.1.7
Bufo bufo
-
toad
-
1.8.1.7
Escherichia coli
-
-
-
1.8.1.7
Homo sapiens
-
-
-
1.8.1.7
Litomosoides carinii
-
-
-
1.8.1.7
Meriones unguiculatus
-
-
-
1.8.1.7
Mus musculus
-
-
-
1.8.1.7
Oryctolagus cuniculus
-
-
-
1.8.1.7
Penicillium chrysogenum
-
-
-
1.8.1.7
Plasmodium vinckei
-
-
-
1.8.1.7
Rattus norvegicus
-
-
-
1.8.1.7
Saccharomyces cerevisiae
-
baker's yeast
-
1.8.1.7
Scombridae
-
-
-
1.8.1.7
Spinacia oleracea
-
spinach
-
1.8.1.7
Sus scrofa
-
-
-
Purification (Commentary)
EC Number
Commentary
Organism
1.8.1.7
partially
Litomosoides carinii
Reaction
EC Number
Reaction
Commentary
Organism
1.8.1.7
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
Escherichia coli
1.8.1.7
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
GSSG-binding site; mechanism
Homo sapiens
1.8.1.7
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
Penicillium chrysogenum
1.8.1.7
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
Rattus norvegicus
1.8.1.7
2 glutathione + NADP+ = glutathione disulfide + NADPH + H+
mechanism
Saccharomyces cerevisiae
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.1.7
erythrocyte
-
Oryctolagus cuniculus
-
1.8.1.7
erythrocyte
-
Sus scrofa
-
1.8.1.7
erythrocyte
-
Homo sapiens
-
1.8.1.7
leaf
-
Spinacia oleracea
-
1.8.1.7
lens fiber
-
Homo sapiens
-
1.8.1.7
leukocyte
-
Homo sapiens
-
1.8.1.7
liver
-
Meriones unguiculatus
-
1.8.1.7
liver
-
Oryctolagus cuniculus
-
1.8.1.7
liver
-
Mus musculus
-
1.8.1.7
liver
-
Bos taurus
-
1.8.1.7
liver
-
Rattus norvegicus
-
1.8.1.7
muscle
-
Scombridae
-
1.8.1.7
platelet
-
Homo sapiens
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.8.1.7
additional information
-
-
Bos taurus
1.8.1.7
additional information
-
-
Escherichia coli
1.8.1.7
additional information
-
activity decreases with age of the organism
Homo sapiens
1.8.1.7
additional information
-
activity decreases with age of the organism
Mus musculus
1.8.1.7
additional information
-
activity decreases with age of the organism
Rattus norvegicus
1.8.1.7
240
-
-
Homo sapiens
Storage Stability
EC Number
Storage Stability
Organism
1.8.1.7
4°C, activation after storage over days, months or years
Mus musculus
1.8.1.7
4°C, activation after storage over days, months or years
Escherichia coli
1.8.1.7
4°C, activation after storage over days, months or years
Homo sapiens
1.8.1.7
4°C, activation after storage over days, months or years
Rattus norvegicus
1.8.1.7
4°C, activation after storage over days, months or years
Sus scrofa
1.8.1.7
4°C, activation after storage over days, months or years
Saccharomyces cerevisiae
1.8.1.7
4°C, activation after storage over days, months or years
Bos taurus
1.8.1.7
4°C, activation after storage over days, months or years
Oryctolagus cuniculus
1.8.1.7
4°C, activation after storage over days, months or years
Penicillium chrysogenum
1.8.1.7
4°C, activation after storage over days, months or years
Spinacia oleracea
1.8.1.7
4°C, activation after storage over days, months or years
Meriones unguiculatus
1.8.1.7
4°C, activation after storage over days, months or years
Allochromatium vinosum
1.8.1.7
4°C, activation after storage over days, months or years
Scombridae
1.8.1.7
4°C, activation after storage over days, months or years
Plasmodium vinckei
1.8.1.7
concentrated solution, years
Mus musculus
1.8.1.7
concentrated solution, years
Escherichia coli
1.8.1.7
concentrated solution, years
Homo sapiens
1.8.1.7
concentrated solution, years
Rattus norvegicus
1.8.1.7
concentrated solution, years
Sus scrofa
1.8.1.7
concentrated solution, years
Saccharomyces cerevisiae
1.8.1.7
concentrated solution, years
Bos taurus
1.8.1.7
concentrated solution, years
Oryctolagus cuniculus
1.8.1.7
concentrated solution, years
Penicillium chrysogenum
1.8.1.7
concentrated solution, years
Spinacia oleracea
1.8.1.7
concentrated solution, years
Meriones unguiculatus
1.8.1.7
concentrated solution, years
Allochromatium vinosum
1.8.1.7
concentrated solution, years
Scombridae
1.8.1.7
concentrated solution, years
Plasmodium vinckei
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.1.7
GSSG + NADPH
-
394708
Mus musculus
glutathione + NADP+
-
394708
Mus musculus
r
1.8.1.7
GSSG + NADPH
-
394708
Rattus norvegicus
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
-
394708
Sus scrofa
glutathione + NADP+
-
394708
Sus scrofa
?
1.8.1.7
GSSG + NADPH
-
394708
Sus scrofa
glutathione + NADP+
-
394708
Sus scrofa
r
1.8.1.7
GSSG + NADPH
-
394708
Bos taurus
glutathione + NADP+
-
394708
Bos taurus
?
1.8.1.7
GSSG + NADPH
-
394708
Bos taurus
glutathione + NADP+
-
394708
Bos taurus
ir
1.8.1.7
GSSG + NADPH
-
394708
Bos taurus
glutathione + NADP+
-
394708
Bos taurus
r
1.8.1.7
GSSG + NADPH
-
394708
Oryctolagus cuniculus
glutathione + NADP+
-
394708
Oryctolagus cuniculus
?
1.8.1.7
GSSG + NADPH
-
394708
Oryctolagus cuniculus
glutathione + NADP+
-
394708
Oryctolagus cuniculus
r
1.8.1.7
GSSG + NADPH
-
394708
Spinacia oleracea
glutathione + NADP+
-
394708
Spinacia oleracea
?
1.8.1.7
GSSG + NADPH
-
394708
Spinacia oleracea
glutathione + NADP+
-
394708
Spinacia oleracea
r
1.8.1.7
GSSG + NADPH
-
394708
Meriones unguiculatus
glutathione + NADP+
-
394708
Meriones unguiculatus
r
1.8.1.7
GSSG + NADPH
-
394708
Allochromatium vinosum
glutathione + NADP+
-
394708
Allochromatium vinosum
r
1.8.1.7
GSSG + NADPH
-
394708
Scombridae
glutathione + NADP+
-
394708
Scombridae
r
1.8.1.7
GSSG + NADPH
-
394708
Plasmodium vinckei
glutathione + NADP+
-
394708
Plasmodium vinckei
r
1.8.1.7
GSSG + NADPH
-
394708
Litomosoides carinii
glutathione + NADP+
-
394708
Litomosoides carinii
?
1.8.1.7
GSSG + NADPH
-
394708
Litomosoides carinii
glutathione + NADP+
-
394708
Litomosoides carinii
r
1.8.1.7
GSSG + NADPH
-
394708
Bufo bufo
glutathione + NADP+
-
394708
Bufo bufo
r
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Escherichia coli
glutathione + NADP+
-
394708
Escherichia coli
?
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Escherichia coli
glutathione + NADP+
-
394708
Escherichia coli
ir
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Escherichia coli
glutathione + NADP+
-
394708
Escherichia coli
r
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
?
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
ir
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
r
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Penicillium chrysogenum
glutathione + NADP+
-
394708
Penicillium chrysogenum
?
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Penicillium chrysogenum
glutathione + NADP+
-
394708
Penicillium chrysogenum
r
1.8.1.7
GSSG + NADPH
slight activity with D,L-lipoate
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
?
1.8.1.7
GSSG + NADPH
slight activity with D,L-lipoate
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
ir
1.8.1.7
GSSG + NADPH
slight activity with D,L-lipoate
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
r
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
?
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
ir
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
r
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
?
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
ir
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
r
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
1.8.1.7
GSSG + NADPH
slight activity with bis-N,N'-(gamma-glutamylcystine)
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
1.8.1.7
GSSG + NADPH
slight activity with bis-N,N'-(gamma-glutamylcystine)
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
1.8.1.7
GSSG + NADPH
glutathione-S-sulfonate
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
1.8.1.7
GSSG + NADPH
glutathione-S-sulfonate
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Mus musculus
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Escherichia coli
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Homo sapiens
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Sus scrofa
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Bos taurus
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Oryctolagus cuniculus
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Penicillium chrysogenum
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Spinacia oleracea
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Meriones unguiculatus
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Allochromatium vinosum
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Scombridae
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Plasmodium vinckei
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
high GSSG level in dormant stage
394708
Bufo bufo
glutathione + NADP+
-
-
-
?
1.8.1.7
additional information
-
394708
Mus musculus
?
-
-
-
-
1.8.1.7
additional information
-
394708
Rattus norvegicus
?
-
-
-
-
1.8.1.7
additional information
-
394708
Sus scrofa
?
-
-
-
-
1.8.1.7
additional information
-
394708
Saccharomyces cerevisiae
?
-
-
-
-
1.8.1.7
additional information
-
394708
Spinacia oleracea
?
-
-
-
-
1.8.1.7
additional information
-
394708
Meriones unguiculatus
?
-
-
-
-
1.8.1.7
additional information
-
394708
Allochromatium vinosum
?
-
-
-
-
1.8.1.7
additional information
glutathione redox cycle
394708
Homo sapiens
?
-
-
-
-
Subunits
EC Number
Subunits
Commentary
Organism
1.8.1.7
dimer
-
Meriones unguiculatus
1.8.1.7
dimer
-
Mus musculus
1.8.1.7
dimer
-
Oryctolagus cuniculus
1.8.1.7
dimer
-
Spinacia oleracea
1.8.1.7
dimer
-
Sus scrofa
1.8.1.7
dimer
-
Rattus norvegicus
1.8.1.7
dimer
2 * 52500
Homo sapiens
1.8.1.7
dimer
-
Escherichia coli
1.8.1.7
dimer
-
Bos taurus
Turnover Number [1/s]
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1.8.1.7
210
-
GSSG
-
Homo sapiens
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.8.1.7
FAD
FAD enzyme
Escherichia coli
1.8.1.7
FAD
FAD enzyme
Meriones unguiculatus
1.8.1.7
FAD
FAD enzyme
Mus musculus
1.8.1.7
FAD
FAD enzyme
Penicillium chrysogenum
1.8.1.7
FAD
FAD enzyme
Plasmodium vinckei
1.8.1.7
FAD
FAD enzyme
Rattus norvegicus
1.8.1.7
FAD
FAD enzyme
Scombridae
1.8.1.7
FAD
FAD enzyme
Sus scrofa
1.8.1.7
FAD
FAD enzyme
Oryctolagus cuniculus
1.8.1.7
FAD
FAD enzyme
Spinacia oleracea
1.8.1.7
FAD
FAD enzyme
Allochromatium vinosum
1.8.1.7
FAD
FAD enzyme
Bos taurus
1.8.1.7
FAD
FAD enzyme
Saccharomyces cerevisiae
1.8.1.7
FAD
FAD enzyme
Homo sapiens
1.8.1.7
flavin
flavoprotein
Allochromatium vinosum
1.8.1.7
flavin
flavoprotein
Homo sapiens
1.8.1.7
flavin
flavoprotein
Meriones unguiculatus
1.8.1.7
flavin
flavoprotein
Mus musculus
1.8.1.7
flavin
flavoprotein
Oryctolagus cuniculus
1.8.1.7
flavin
flavoprotein
Penicillium chrysogenum
1.8.1.7
flavin
flavoprotein
Plasmodium vinckei
1.8.1.7
flavin
flavoprotein
Saccharomyces cerevisiae
1.8.1.7
flavin
flavoprotein
Scombridae
1.8.1.7
flavin
flavoprotein
Spinacia oleracea
1.8.1.7
flavin
flavoprotein
Sus scrofa
1.8.1.7
flavin
flavoprotein
Bos taurus
1.8.1.7
flavin
flavoprotein
Rattus norvegicus
1.8.1.7
flavin
flavoprotein
Escherichia coli
1.8.1.7
NADH
-
Allochromatium vinosum
1.8.1.7
NADH
20times less activity than with NADPH
Homo sapiens
1.8.1.7
NADH
-
Rattus norvegicus
1.8.1.7
NADH
-
Spinacia oleracea
1.8.1.7
NADH
-
Sus scrofa
1.8.1.7
NADPH
can utilize both NADPH and NADH, more active with NADPH
Allochromatium vinosum
1.8.1.7
NADPH
-
Bufo bufo
1.8.1.7
NADPH
20times more activity than with NADH; can utilize both NADPH and NADH, more active with NADPH
Homo sapiens
1.8.1.7
NADPH
-
Litomosoides carinii
1.8.1.7
NADPH
-
Meriones unguiculatus
1.8.1.7
NADPH
-
Penicillium chrysogenum
1.8.1.7
NADPH
-
Plasmodium vinckei
1.8.1.7
NADPH
-
Scombridae
1.8.1.7
NADPH
-
Oryctolagus cuniculus
1.8.1.7
NADPH
-
Sus scrofa
1.8.1.7
NADPH
-
Escherichia coli
1.8.1.7
NADPH
-
Mus musculus
1.8.1.7
NADPH
-
Saccharomyces cerevisiae
1.8.1.7
NADPH
-
Spinacia oleracea
1.8.1.7
NADPH
-
Bos taurus
1.8.1.7
NADPH
-
Rattus norvegicus
Ki Value [mM]
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.8.1.7
0.00033
-
Hg2+
-
Rattus norvegicus
1.8.1.7
0.0005
-
2,4,6-trinitrobenzene-sulfonate
below, at 50% inhibition value, leading to oxidase activity
Bos taurus
1.8.1.7
0.0008
-
Zn2+
at 50% inhibition value
Homo sapiens
1.8.1.7
0.001
-
Cd2+
at 50% inhibition value
Homo sapiens
1.8.1.7
0.001
-
Cu2+
at 50% inhibition value
Saccharomyces cerevisiae
1.8.1.7
0.001
-
Nitrofurantoin
at 50% inhibition value, enzyme partially purified from platelets
Homo sapiens
1.8.1.7
0.005
-
Zn2+
at 50% inhibition value
Homo sapiens
1.8.1.7
0.0065
-
Zn2+
at 50% inhibition value
Rattus norvegicus
1.8.1.7
0.0091
-
Melarsen oxide
at 50% inhibition value
Litomosoides carinii
1.8.1.7
0.01
-
p-hydroxymercuribenzoate
-
Escherichia coli
1.8.1.7
0.02
-
Nitrofurantoin
at 50% inhibition value
Rattus norvegicus
1.8.1.7
0.022
-
1-chloro-2,4-dinitrobenzene
at 50% inhibition value
Homo sapiens
1.8.1.7
0.025
-
Nitrofurantoin
at 50% inhibition value, enzyme from erythrocytes
Homo sapiens
1.8.1.7
0.03
-
nifurtimox
at 50% inhibition value
Rattus norvegicus
1.8.1.7
0.03
-
S-(2,4-dinitrophenyl)-glutathione
at 50% inhibition value
Homo sapiens
1.8.1.7
0.04
-
nifurtimox
at 50% inhibition value
Homo sapiens
1.8.1.7
0.25
-
Cd2+
-
Scombridae
1.8.1.7
0.25
-
Melarsen oxide
at 50% inhibition value
Homo sapiens
1.8.1.7
0.35
-
chromate
at 50% inhibition value
Homo sapiens
1.8.1.7
0.35
-
chromate
-
Rattus norvegicus
1.8.1.7
1.1
-
Nitrogen mustard
at 50% inhibition value
Homo sapiens
1.8.1.7
2.2
9
arsenite
at 50% inhibition value
Homo sapiens
1.8.1.7
3
-
arsenite
at 50% inhibition value
Litomosoides carinii
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.8.1.7
FAD
FAD enzyme
Escherichia coli
1.8.1.7
FAD
FAD enzyme
Meriones unguiculatus
1.8.1.7
FAD
FAD enzyme
Mus musculus
1.8.1.7
FAD
FAD enzyme
Penicillium chrysogenum
1.8.1.7
FAD
FAD enzyme
Plasmodium vinckei
1.8.1.7
FAD
FAD enzyme
Rattus norvegicus
1.8.1.7
FAD
FAD enzyme
Scombridae
1.8.1.7
FAD
FAD enzyme
Sus scrofa
1.8.1.7
FAD
FAD enzyme
Oryctolagus cuniculus
1.8.1.7
FAD
FAD enzyme
Spinacia oleracea
1.8.1.7
FAD
FAD enzyme
Allochromatium vinosum
1.8.1.7
FAD
FAD enzyme
Bos taurus
1.8.1.7
FAD
FAD enzyme
Saccharomyces cerevisiae
1.8.1.7
FAD
FAD enzyme
Homo sapiens
1.8.1.7
flavin
flavoprotein
Allochromatium vinosum
1.8.1.7
flavin
flavoprotein
Homo sapiens
1.8.1.7
flavin
flavoprotein
Meriones unguiculatus
1.8.1.7
flavin
flavoprotein
Mus musculus
1.8.1.7
flavin
flavoprotein
Oryctolagus cuniculus
1.8.1.7
flavin
flavoprotein
Penicillium chrysogenum
1.8.1.7
flavin
flavoprotein
Plasmodium vinckei
1.8.1.7
flavin
flavoprotein
Saccharomyces cerevisiae
1.8.1.7
flavin
flavoprotein
Scombridae
1.8.1.7
flavin
flavoprotein
Spinacia oleracea
1.8.1.7
flavin
flavoprotein
Sus scrofa
1.8.1.7
flavin
flavoprotein
Bos taurus
1.8.1.7
flavin
flavoprotein
Rattus norvegicus
1.8.1.7
flavin
flavoprotein
Escherichia coli
1.8.1.7
NADH
-
Allochromatium vinosum
1.8.1.7
NADH
20times less activity than with NADPH
Homo sapiens
1.8.1.7
NADH
-
Rattus norvegicus
1.8.1.7
NADH
-
Spinacia oleracea
1.8.1.7
NADH
-
Sus scrofa
1.8.1.7
NADPH
can utilize both NADPH and NADH, more active with NADPH
Allochromatium vinosum
1.8.1.7
NADPH
-
Bufo bufo
1.8.1.7
NADPH
20times more activity than with NADH; can utilize both NADPH and NADH, more active with NADPH
Homo sapiens
1.8.1.7
NADPH
-
Litomosoides carinii
1.8.1.7
NADPH
-
Meriones unguiculatus
1.8.1.7
NADPH
-
Penicillium chrysogenum
1.8.1.7
NADPH
-
Plasmodium vinckei
1.8.1.7
NADPH
-
Scombridae
1.8.1.7
NADPH
-
Oryctolagus cuniculus
1.8.1.7
NADPH
-
Sus scrofa
1.8.1.7
NADPH
-
Escherichia coli
1.8.1.7
NADPH
-
Mus musculus
1.8.1.7
NADPH
-
Saccharomyces cerevisiae
1.8.1.7
NADPH
-
Spinacia oleracea
1.8.1.7
NADPH
-
Bos taurus
1.8.1.7
NADPH
-
Rattus norvegicus
Crystallization (Commentary) (protein specific)
EC Number
Crystallization
Organism
1.8.1.7
molecular asymmetry of crystals from deionized water and from 2 M ammonium sulfate, exact 2fold molecular axis in the dimer, form A-D, three-dimensional structure
Homo sapiens
1.8.1.7
trigonal crystals, high internal symmetry
Escherichia coli
General Stability (protein specific)
EC Number
General Stability
Organism
1.8.1.7
concentrated solution, stable for years
Mus musculus
1.8.1.7
concentrated solution, stable for years
Escherichia coli
1.8.1.7
concentrated solution, stable for years
Homo sapiens
1.8.1.7
concentrated solution, stable for years
Rattus norvegicus
1.8.1.7
concentrated solution, stable for years
Sus scrofa
1.8.1.7
concentrated solution, stable for years
Saccharomyces cerevisiae
1.8.1.7
concentrated solution, stable for years
Bos taurus
1.8.1.7
concentrated solution, stable for years
Oryctolagus cuniculus
1.8.1.7
concentrated solution, stable for years
Penicillium chrysogenum
1.8.1.7
concentrated solution, stable for years
Spinacia oleracea
1.8.1.7
concentrated solution, stable for years
Meriones unguiculatus
1.8.1.7
concentrated solution, stable for years
Allochromatium vinosum
1.8.1.7
concentrated solution, stable for years
Scombridae
1.8.1.7
concentrated solution, stable for years
Plasmodium vinckei
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Mus musculus
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Escherichia coli
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Homo sapiens
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Rattus norvegicus
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Sus scrofa
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Saccharomyces cerevisiae
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Bos taurus
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Oryctolagus cuniculus
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Penicillium chrysogenum
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Spinacia oleracea
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Meriones unguiculatus
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Allochromatium vinosum
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Scombridae
1.8.1.7
crystals and amorphous protein obtained by precipitation with ammonium sulfate are stable
Plasmodium vinckei
1.8.1.7
repeated freezing and thawing, inactivation
Mus musculus
1.8.1.7
repeated freezing and thawing, inactivation
Escherichia coli
1.8.1.7
repeated freezing and thawing, inactivation
Homo sapiens
1.8.1.7
repeated freezing and thawing, inactivation
Rattus norvegicus
1.8.1.7
repeated freezing and thawing, inactivation
Sus scrofa
1.8.1.7
repeated freezing and thawing, inactivation
Saccharomyces cerevisiae
1.8.1.7
repeated freezing and thawing, inactivation
Bos taurus
1.8.1.7
repeated freezing and thawing, inactivation
Oryctolagus cuniculus
1.8.1.7
repeated freezing and thawing, inactivation
Penicillium chrysogenum
1.8.1.7
repeated freezing and thawing, inactivation
Spinacia oleracea
1.8.1.7
repeated freezing and thawing, inactivation
Meriones unguiculatus
1.8.1.7
repeated freezing and thawing, inactivation
Allochromatium vinosum
1.8.1.7
repeated freezing and thawing, inactivation
Scombridae
1.8.1.7
repeated freezing and thawing, inactivation
Plasmodium vinckei
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.8.1.7
1,2-Cyclohexanedione
-
Homo sapiens
1.8.1.7
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
Homo sapiens
1.8.1.7
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
Rattus norvegicus
1.8.1.7
1,3-Bis-(2-chloroethyl)-1-nitrosourea
-
Saccharomyces cerevisiae
1.8.1.7
1-(2-Chloroethyl)-3-(2-hydroxyethyl)-1-nitrosourea
-
Homo sapiens
1.8.1.7
1-chloro-2,4-dinitrobenzene
reversible
Homo sapiens
1.8.1.7
1-Fluoro-2,4-dinitrobenzene
reversible
Saccharomyces cerevisiae
1.8.1.7
2,3-Butanedione
-
Homo sapiens
1.8.1.7
2,4,6-Trinitrobenzenesulfonate
reversible
Bos taurus
1.8.1.7
2-Chloroethylisocyanate
-
Saccharomyces cerevisiae
1.8.1.7
arsenite
-
Homo sapiens
1.8.1.7
arsenite
-
Litomosoides carinii
1.8.1.7
arsenite
-
Rattus norvegicus
1.8.1.7
arsenite
-
Saccharomyces cerevisiae
1.8.1.7
Benzylselenosulfate
-
Rattus norvegicus
1.8.1.7
Cd2+
-
Homo sapiens
1.8.1.7
Cd2+
-
Scombridae
1.8.1.7
chromate
-
Allochromatium vinosum
1.8.1.7
chromate
-
Bos taurus
1.8.1.7
chromate
-
Escherichia coli
1.8.1.7
chromate
-
Homo sapiens
1.8.1.7
chromate
-
Meriones unguiculatus
1.8.1.7
chromate
-
Mus musculus
1.8.1.7
chromate
-
Oryctolagus cuniculus
1.8.1.7
chromate
-
Penicillium chrysogenum
1.8.1.7
chromate
-
Plasmodium vinckei
1.8.1.7
chromate
probably irreversible
Rattus norvegicus
1.8.1.7
chromate
-
Saccharomyces cerevisiae
1.8.1.7
chromate
-
Scombridae
1.8.1.7
chromate
-
Spinacia oleracea
1.8.1.7
chromate
-
Sus scrofa
1.8.1.7
Cu2+
-
Saccharomyces cerevisiae
1.8.1.7
Cu2+
-
Allochromatium vinosum
1.8.1.7
Dinitrosated isomers of N,N'-bis[N(2-chloroethyl)-N-carbonyl]cysteamine
-
Rattus norvegicus
1.8.1.7
Haemin
mediates covalent cross-linking and degradation of the enzyme
Saccharomyces cerevisiae
1.8.1.7
Hg2+
-
Rattus norvegicus
1.8.1.7
Iodine
-
Saccharomyces cerevisiae
1.8.1.7
iodoacetamide
-
Homo sapiens
1.8.1.7
iodoacetamide
-
Saccharomyces cerevisiae
1.8.1.7
Melarsen oxide
-
Homo sapiens
1.8.1.7
Melarsen oxide
-
Litomosoides carinii
1.8.1.7
additional information
regulation by inactivation in vivo, e.g. by disulfide bridging
Homo sapiens
1.8.1.7
additional information
regulation by inactivation in vivo, e.g. by disulfide bridging
Mus musculus
1.8.1.7
additional information
regulation by inactivation in vivo, e.g. by disulfide bridging
Saccharomyces cerevisiae
1.8.1.7
N,N'-bis(trans-4-hydroxycyclohexyl)-N'-nitrosourea
-
Rattus norvegicus
1.8.1.7
N-Alkylmaleimide
-
Saccharomyces cerevisiae
1.8.1.7
nifurtimox
-
Homo sapiens
1.8.1.7
nifurtimox
-
Rattus norvegicus
1.8.1.7
Nitrofurantoin
-
Allochromatium vinosum
1.8.1.7
Nitrofurantoin
-
Bos taurus
1.8.1.7
Nitrofurantoin
-
Escherichia coli
1.8.1.7
Nitrofurantoin
-
Homo sapiens
1.8.1.7
Nitrofurantoin
-
Meriones unguiculatus
1.8.1.7
Nitrofurantoin
-
Mus musculus
1.8.1.7
Nitrofurantoin
-
Oryctolagus cuniculus
1.8.1.7
Nitrofurantoin
-
Penicillium chrysogenum
1.8.1.7
Nitrofurantoin
-
Plasmodium vinckei
1.8.1.7
Nitrofurantoin
-
Rattus norvegicus
1.8.1.7
Nitrofurantoin
-
Saccharomyces cerevisiae
1.8.1.7
Nitrofurantoin
-
Scombridae
1.8.1.7
Nitrofurantoin
-
Spinacia oleracea
1.8.1.7
Nitrofurantoin
-
Sus scrofa
1.8.1.7
Nitrogen mustard
-
Homo sapiens
1.8.1.7
p-hydroxymercuribenzoate
-
Escherichia coli
1.8.1.7
p-hydroxymercuribenzoate
-
Oryctolagus cuniculus
1.8.1.7
p-hydroxymercuribenzoate
-
Rattus norvegicus
1.8.1.7
p-hydroxymercuribenzoate
-
Meriones unguiculatus
1.8.1.7
p-hydroxymercuribenzoate
-
Allochromatium vinosum
1.8.1.7
Phenylarsonous acid
-
Saccharomyces cerevisiae
1.8.1.7
Phenylglyoxal
-
Homo sapiens
1.8.1.7
Phenylglyoxal
-
Saccharomyces cerevisiae
1.8.1.7
S-(2,4-dinitrophenyl)-glutathione
-
Homo sapiens
1.8.1.7
Zn2+
-
Homo sapiens
1.8.1.7
Zn2+
-
Rattus norvegicus
1.8.1.7
Zn2+
-
Spinacia oleracea
Ki Value [mM] (protein specific)
EC Number
Ki Value [mM]
Ki Value maximum [mM]
Inhibitor
Commentary
Organism
Structure
1.8.1.7
0.00033
-
Hg2+
-
Rattus norvegicus
1.8.1.7
0.0005
-
2,4,6-trinitrobenzene-sulfonate
below, at 50% inhibition value, leading to oxidase activity
Bos taurus
1.8.1.7
0.0008
-
Zn2+
at 50% inhibition value
Homo sapiens
1.8.1.7
0.001
-
Cd2+
at 50% inhibition value
Homo sapiens
1.8.1.7
0.001
-
Cu2+
at 50% inhibition value
Saccharomyces cerevisiae
1.8.1.7
0.001
-
Nitrofurantoin
at 50% inhibition value, enzyme partially purified from platelets
Homo sapiens
1.8.1.7
0.005
-
Zn2+
at 50% inhibition value
Homo sapiens
1.8.1.7
0.0065
-
Zn2+
at 50% inhibition value
Rattus norvegicus
1.8.1.7
0.0091
-
Melarsen oxide
at 50% inhibition value
Litomosoides carinii
1.8.1.7
0.01
-
p-hydroxymercuribenzoate
-
Escherichia coli
1.8.1.7
0.02
-
Nitrofurantoin
at 50% inhibition value
Rattus norvegicus
1.8.1.7
0.022
-
1-chloro-2,4-dinitrobenzene
at 50% inhibition value
Homo sapiens
1.8.1.7
0.025
-
Nitrofurantoin
at 50% inhibition value, enzyme from erythrocytes
Homo sapiens
1.8.1.7
0.03
-
nifurtimox
at 50% inhibition value
Rattus norvegicus
1.8.1.7
0.03
-
S-(2,4-dinitrophenyl)-glutathione
at 50% inhibition value
Homo sapiens
1.8.1.7
0.04
-
nifurtimox
at 50% inhibition value
Homo sapiens
1.8.1.7
0.25
-
Cd2+
-
Scombridae
1.8.1.7
0.25
-
Melarsen oxide
at 50% inhibition value
Homo sapiens
1.8.1.7
0.35
-
chromate
at 50% inhibition value
Homo sapiens
1.8.1.7
0.35
-
chromate
-
Rattus norvegicus
1.8.1.7
1.1
-
Nitrogen mustard
at 50% inhibition value
Homo sapiens
1.8.1.7
2.2
9
arsenite
at 50% inhibition value
Homo sapiens
1.8.1.7
3
-
arsenite
at 50% inhibition value
Litomosoides carinii
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.8.1.7
0.008
-
NADPH
-
Homo sapiens
1.8.1.7
0.008
-
NADPH
-
Oryctolagus cuniculus
1.8.1.7
0.008
-
NADPH
-
Rattus norvegicus
1.8.1.7
0.065
-
GSSG
-
Homo sapiens
1.8.1.7
0.25
-
glutathione-S-sulfonate
-
Saccharomyces cerevisiae
1.8.1.7
1
-
mixed disulfide of coenzyme A and glutathione
-
Homo sapiens
1.8.1.7
7
-
GSSG
-
Allochromatium vinosum
1.8.1.7
11.6
-
bis-N,N'-(gamma-glutamylcystine)
-
Saccharomyces cerevisiae
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.8.1.7
chloroplast
cytoplasm-like spaces of chloroplasts
Spinacia oleracea
9507
-
1.8.1.7
cytoplasm
-
Bos taurus
5737
-
1.8.1.7
cytoplasm
-
Rattus norvegicus
5737
-
1.8.1.7
mitochondrion
cytoplasm-like spaces of mitochondria
Rattus norvegicus
5739
-
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.8.1.7
52500
-
2 * 52500
Homo sapiens
Natural Substrates/ Products (Substrates) (protein specific)
EC Number
Natural Substrates
Organism
Commentary (Nat. Sub.)
Natural Products
Commentary (Nat. Pro.)
Organism (Nat. Pro.)
Reversibility
1.8.1.7
GSSG + NADPH
Rattus norvegicus
-
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Mus musculus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Escherichia coli
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Homo sapiens
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Sus scrofa
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Saccharomyces cerevisiae
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Bos taurus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Oryctolagus cuniculus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Penicillium chrysogenum
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Spinacia oleracea
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Meriones unguiculatus
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Allochromatium vinosum
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Scombridae
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Plasmodium vinckei
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
glutathione + NADP+
-
-
?
1.8.1.7
GSSG + NADPH
Bufo bufo
high GSSG level in dormant stage
glutathione + NADP+
-
-
?
1.8.1.7
additional information
Homo sapiens
glutathione redox cycle
?
-
-
-
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.8.1.7
partially
Litomosoides carinii
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.1.7
erythrocyte
-
Oryctolagus cuniculus
-
1.8.1.7
erythrocyte
-
Sus scrofa
-
1.8.1.7
erythrocyte
-
Homo sapiens
-
1.8.1.7
leaf
-
Spinacia oleracea
-
1.8.1.7
lens fiber
-
Homo sapiens
-
1.8.1.7
leukocyte
-
Homo sapiens
-
1.8.1.7
liver
-
Meriones unguiculatus
-
1.8.1.7
liver
-
Oryctolagus cuniculus
-
1.8.1.7
liver
-
Mus musculus
-
1.8.1.7
liver
-
Bos taurus
-
1.8.1.7
liver
-
Rattus norvegicus
-
1.8.1.7
muscle
-
Scombridae
-
1.8.1.7
platelet
-
Homo sapiens
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [µmol/min/mg]
Specific Activity Maximum [µmol/min/mg]
Commentary
Organism
1.8.1.7
additional information
-
-
Bos taurus
1.8.1.7
additional information
-
-
Escherichia coli
1.8.1.7
additional information
-
activity decreases with age of the organism
Homo sapiens
1.8.1.7
additional information
-
activity decreases with age of the organism
Mus musculus
1.8.1.7
additional information
-
activity decreases with age of the organism
Rattus norvegicus
1.8.1.7
240
-
-
Homo sapiens
Storage Stability (protein specific)
EC Number
Storage Stability
Organism
1.8.1.7
4°C, activation after storage over days, months or years
Mus musculus
1.8.1.7
4°C, activation after storage over days, months or years
Escherichia coli
1.8.1.7
4°C, activation after storage over days, months or years
Homo sapiens
1.8.1.7
4°C, activation after storage over days, months or years
Rattus norvegicus
1.8.1.7
4°C, activation after storage over days, months or years
Sus scrofa
1.8.1.7
4°C, activation after storage over days, months or years
Saccharomyces cerevisiae
1.8.1.7
4°C, activation after storage over days, months or years
Bos taurus
1.8.1.7
4°C, activation after storage over days, months or years
Oryctolagus cuniculus
1.8.1.7
4°C, activation after storage over days, months or years
Penicillium chrysogenum
1.8.1.7
4°C, activation after storage over days, months or years
Spinacia oleracea
1.8.1.7
4°C, activation after storage over days, months or years
Meriones unguiculatus
1.8.1.7
4°C, activation after storage over days, months or years
Allochromatium vinosum
1.8.1.7
4°C, activation after storage over days, months or years
Scombridae
1.8.1.7
4°C, activation after storage over days, months or years
Plasmodium vinckei
1.8.1.7
concentrated solution, years
Mus musculus
1.8.1.7
concentrated solution, years
Escherichia coli
1.8.1.7
concentrated solution, years
Homo sapiens
1.8.1.7
concentrated solution, years
Rattus norvegicus
1.8.1.7
concentrated solution, years
Sus scrofa
1.8.1.7
concentrated solution, years
Saccharomyces cerevisiae
1.8.1.7
concentrated solution, years
Bos taurus
1.8.1.7
concentrated solution, years
Oryctolagus cuniculus
1.8.1.7
concentrated solution, years
Penicillium chrysogenum
1.8.1.7
concentrated solution, years
Spinacia oleracea
1.8.1.7
concentrated solution, years
Meriones unguiculatus
1.8.1.7
concentrated solution, years
Allochromatium vinosum
1.8.1.7
concentrated solution, years
Scombridae
1.8.1.7
concentrated solution, years
Plasmodium vinckei
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.1.7
GSSG + NADPH
-
394708
Mus musculus
glutathione + NADP+
-
394708
Mus musculus
r
1.8.1.7
GSSG + NADPH
-
394708
Rattus norvegicus
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
-
394708
Sus scrofa
glutathione + NADP+
-
394708
Sus scrofa
?
1.8.1.7
GSSG + NADPH
-
394708
Sus scrofa
glutathione + NADP+
-
394708
Sus scrofa
r
1.8.1.7
GSSG + NADPH
-
394708
Bos taurus
glutathione + NADP+
-
394708
Bos taurus
?
1.8.1.7
GSSG + NADPH
-
394708
Bos taurus
glutathione + NADP+
-
394708
Bos taurus
ir
1.8.1.7
GSSG + NADPH
-
394708
Bos taurus
glutathione + NADP+
-
394708
Bos taurus
r
1.8.1.7
GSSG + NADPH
-
394708
Oryctolagus cuniculus
glutathione + NADP+
-
394708
Oryctolagus cuniculus
?
1.8.1.7
GSSG + NADPH
-
394708
Oryctolagus cuniculus
glutathione + NADP+
-
394708
Oryctolagus cuniculus
r
1.8.1.7
GSSG + NADPH
-
394708
Spinacia oleracea
glutathione + NADP+
-
394708
Spinacia oleracea
?
1.8.1.7
GSSG + NADPH
-
394708
Spinacia oleracea
glutathione + NADP+
-
394708
Spinacia oleracea
r
1.8.1.7
GSSG + NADPH
-
394708
Meriones unguiculatus
glutathione + NADP+
-
394708
Meriones unguiculatus
r
1.8.1.7
GSSG + NADPH
-
394708
Allochromatium vinosum
glutathione + NADP+
-
394708
Allochromatium vinosum
r
1.8.1.7
GSSG + NADPH
-
394708
Scombridae
glutathione + NADP+
-
394708
Scombridae
r
1.8.1.7
GSSG + NADPH
-
394708
Plasmodium vinckei
glutathione + NADP+
-
394708
Plasmodium vinckei
r
1.8.1.7
GSSG + NADPH
-
394708
Litomosoides carinii
glutathione + NADP+
-
394708
Litomosoides carinii
?
1.8.1.7
GSSG + NADPH
-
394708
Litomosoides carinii
glutathione + NADP+
-
394708
Litomosoides carinii
r
1.8.1.7
GSSG + NADPH
-
394708
Bufo bufo
glutathione + NADP+
-
394708
Bufo bufo
r
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Escherichia coli
glutathione + NADP+
-
394708
Escherichia coli
?
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Escherichia coli
glutathione + NADP+
-
394708
Escherichia coli
ir
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Escherichia coli
glutathione + NADP+
-
394708
Escherichia coli
r
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
?
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
ir
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
r
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Penicillium chrysogenum
glutathione + NADP+
-
394708
Penicillium chrysogenum
?
1.8.1.7
GSSG + NADPH
glutathione or other disulfides, e.g.: bis-L-gamma-glutamyl-L-cystinyl-bis-beta-alanine
394708
Penicillium chrysogenum
glutathione + NADP+
-
394708
Penicillium chrysogenum
r
1.8.1.7
GSSG + NADPH
slight activity with D,L-lipoate
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
?
1.8.1.7
GSSG + NADPH
slight activity with D,L-lipoate
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
ir
1.8.1.7
GSSG + NADPH
slight activity with D,L-lipoate
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
r
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
?
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
ir
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Homo sapiens
glutathione + NADP+
-
394708
Homo sapiens
r
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
?
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
ir
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Rattus norvegicus
glutathione + NADP+
-
394708
Rattus norvegicus
r
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
1.8.1.7
GSSG + NADPH
mixed disulfide between coenzyme A and glutathione
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
1.8.1.7
GSSG + NADPH
slight activity with bis-N,N'-(gamma-glutamylcystine)
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
1.8.1.7
GSSG + NADPH
slight activity with bis-N,N'-(gamma-glutamylcystine)
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
1.8.1.7
GSSG + NADPH
glutathione-S-sulfonate
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
?
1.8.1.7
GSSG + NADPH
glutathione-S-sulfonate
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
394708
Saccharomyces cerevisiae
r
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Mus musculus
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Escherichia coli
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Homo sapiens
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Sus scrofa
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Saccharomyces cerevisiae
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Bos taurus
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Oryctolagus cuniculus
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Penicillium chrysogenum
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Spinacia oleracea
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Meriones unguiculatus
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Allochromatium vinosum
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Scombridae
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
maintenance of glutathione/GSSG ratio is a protective mechanism for intracellular thiols during growth in atmospheric oxygen
394708
Plasmodium vinckei
glutathione + NADP+
-
-
-
?
1.8.1.7
GSSG + NADPH
high GSSG level in dormant stage
394708
Bufo bufo
glutathione + NADP+
-
-
-
?
1.8.1.7
additional information
-
394708
Mus musculus
?
-
-
-
-
1.8.1.7
additional information
-
394708
Rattus norvegicus
?
-
-
-
-
1.8.1.7
additional information
-
394708
Sus scrofa
?
-
-
-
-
1.8.1.7
additional information
-
394708
Saccharomyces cerevisiae
?
-
-
-
-
1.8.1.7
additional information
-
394708
Spinacia oleracea
?
-
-
-
-
1.8.1.7
additional information
-
394708
Meriones unguiculatus
?
-
-
-
-
1.8.1.7
additional information
-
394708
Allochromatium vinosum
?
-
-
-
-
1.8.1.7
additional information
glutathione redox cycle
394708
Homo sapiens
?
-
-
-
-
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
1.8.1.7
dimer
-
Meriones unguiculatus
1.8.1.7
dimer
-
Mus musculus
1.8.1.7
dimer
-
Oryctolagus cuniculus
1.8.1.7
dimer
-
Spinacia oleracea
1.8.1.7
dimer
-
Sus scrofa
1.8.1.7
dimer
-
Rattus norvegicus
1.8.1.7
dimer
2 * 52500
Homo sapiens
1.8.1.7
dimer
-
Escherichia coli
1.8.1.7
dimer
-
Bos taurus
Turnover Number [1/s] (protein specific)
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1.8.1.7
210
-
GSSG
-
Homo sapiens