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Literature summary extracted from

  • Hiro, I.; Tsugeno, Y.; Hirashiki, I.; Ogata, F.; Ito, A.
    Characterization of rat monoamine oxidase A with noncovalently-bound FAD expressed in yeast cells (1996), J. Biochem., 120, 759-765.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.4 expression in Saccharomyces cerevisiae YSA-1C Rattus norvegicus

Protein Variants

EC Number Protein Variants Comment Organism
1.4.3.4 C406A MAO-A, Km for serotonin and tyramine not altered Rattus norvegicus

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 Clorgyline
-
 Rattus norvegicus
1.4.3.4 Pargyline irreversible inhibitor Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 additional information
-
 additional information Km of wild-type MAO-A and B and of their chimera Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrion
-
 Rattus norvegicus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining

Storage Stability

EC Number Storage Stability Organism
1.4.3.4 30°C, 8 h, 30% of initial activity of Ala-mutated enzyme, in the presence of 0.005 mM FAD 70% of activity Rattus norvegicus
1.4.3.4 30°C, 8 h, no decrease in activity of wild-type enzyme Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 RCH2NH2 + H2O + O2
-
 Rattus norvegicus RCHO + NH3 + H2O2
-
 ?
1.4.3.4 serotonin + H2O + O2
-
 Rattus norvegicus (5-hydroxy-1H-indol-3-yl)acetaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 tyramine + H2O + O2
-
 Rattus norvegicus (4-hydroxyphenyl)acetaldehyde + NH3 + H2O2
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.4 flavin FAD is covalent linkage at Cys406 in MAO-A and is not essentiell for the catalytically activity Rattus norvegicus