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Literature summary extracted from

  • Newton-Vinson, P.; Hubalek, F.; Edmondson, D.E.
    High-level expression of human liver monoamine oxidase B in Pichia pastoris (2000), Protein Expr. Purif., 20, 334-345.
    View publication on PubMed

Cloned(Commentary)

EC Number Cloned (Comment) Organism
1.4.3.4 expression in Pichia pastoris Homo sapiens

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.4.3.4 (aminomethyl)trimethylsilane
-
 Homo sapiens
1.4.3.4 5-(aminomethyl)-3-aryl-2-oxazolidinones
-
 Homo sapiens
1.4.3.4 Pargyline MAO-B sensitive Homo sapiens

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.4.3.4 additional information
-
 additional information
-
 Homo sapiens
1.4.3.4 additional information
-
 additional information
-
 Bos taurus
1.4.3.4 0.33
-
 O2
-
 Homo sapiens
1.4.3.4 0.5
-
 benzylamine
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.4.3.4 mitochondrial outer membrane
-
 Homo sapiens 5741
-

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.4.3.4 59163
-
 x * 59163, electrospray mass spectroscopy, including one covalent FAD, MAO-B Homo sapiens
1.4.3.4 59474
-
 x * 60000, SDS-PAGE, x * 59474, electrospray mass spectroscopy, including one covalent FAD, MAO-B Homo sapiens
1.4.3.4 60000
-
 x * 60000, SDS-PAGE, x * 59474, electrospray mass spectroscopy, including one covalent FAD, MAO-B Homo sapiens

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.4.3.4 RCH2NH2 + H2O + O2 Bos taurus responsible for the catabolism of various biogenic amine neurotransmitters as well as for the metabolism of certain exogenous amines RCHO + NH3 + H2O2
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.4.3.4 Bos taurus
-
-
-
1.4.3.4 Homo sapiens
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.4.3.4
-
 Homo sapiens

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.4.3.4 liver
-
 Homo sapiens
-
1.4.3.4 liver
-
 Bos taurus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.4.3.4 additional information
-
-
 Homo sapiens
1.4.3.4 additional information
-
-
 Bos taurus

Storage Stability

EC Number Storage Stability Organism
1.4.3.4 considerable stability to handling and storage, MAO-B Homo sapiens

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.4.3.4 benzylamine + H2O + O2
-
 Homo sapiens benzaldehyde + NH3 + H2O2
-
 ?
1.4.3.4 RCH2NH2 + H2O + O2 responsible for the catabolism of various biogenic amine neurotransmitters as well as for the metabolism of certain exogenous amines Bos taurus RCHO + NH3 + H2O2
-
 ?

Subunits

EC Number Subunits Comment Organism
1.4.3.4 ? x * 59163, electrospray mass spectroscopy, including one covalent FAD, MAO-B Homo sapiens
1.4.3.4 ? x * 60000, SDS-PAGE, x * 59474, electrospray mass spectroscopy, including one covalent FAD, MAO-B Homo sapiens

Turnover Number [1/s]

EC Number Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
1.4.3.4 10
-
 benzylamine recombinant MAO-B Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.4.3.4 flavin 1 mol FAD per mol of MAO B is covalently bound by an 8-alpha-S-cysteinyl 397 linkage Homo sapiens