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Literature summary extracted from

  • Huang, M.T.; Miwa, G.T.; Cronheim, N.; Lu, A.Y.H.
    Rat liver cytosolic azoreductase. Electron transport properties and the mechanism of dicumarol inhibition of the purified enzyme (1979), J. Biol. Chem., 254, 11223-11227.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.7.1.6 dicoumarol 0.0001 mM, 50% inhibition of methyl red reduction, 0.0004 mM, 90% inhibition, competitive vs. NADPH noncompetitve vs. methyl red Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.7.1.6 dicoumarol
-
 Rattus norvegicus

Organism

EC Number Organism UniProt Comment Textmining
1.7.1.6 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.7.1.6 liver
-
 Rattus norvegicus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.7.1.6 57
-
-
 Rattus norvegicus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.7.1.6 2 ferricyanide + NADPH
-
 Rattus norvegicus 2 ferrocyanide + NADP+ + H+
-
 ?
1.7.1.6 4-(dimethylamino)azobenzene + 2 NADPH electron transport protein Rattus norvegicus N,N-dimethyl-1,4-phenylenediamine + aniline + 2 NADP+ + 2 H+
-
 ?
1.7.1.6 NADPH + 9,10-phenanthrenequinone
-
 Rattus norvegicus NADP+ + 9,10-phenanthrenequinol
-
 ?
1.7.1.6 NADPH + H+ + 1,4-benzoquinone
-
 Rattus norvegicus NADP+ + 1,4-benzoquinol
-
 ?
1.7.1.6 NADPH + H+ + 1,4-naphthoquinone
-
 Rattus norvegicus NADP+ + 1,4-naphthoquinol
-
 ?
1.7.1.6 NADPH + H+ + oxidized 2,6-dichlorophenolindophenol
-
 Rattus norvegicus NADP+ + reduced 2,6-dichlorophenolindophenol
-
 ?
1.7.1.6 NADPH + oxidized cytochrome c in the presence of menadione as electron carrier Rattus norvegicus NADP+ + reduced cytochrome c
-
 ?

Ki Value [mM]

EC Number Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
1.7.1.6 0.00003
-
 dicoumarol vs. NADPH Rattus norvegicus
1.7.1.6 0.00011
-
 dicoumarol vs. methyl red Rattus norvegicus