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Literature summary extracted from

  • Mager, J.; Magasanik, B.
    Guanosine 5'-phosphate reductase and its role in the interconversion of purine nucleotides (1960), J. Biol. Chem., 235, 1474-1478.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.7.1.7 AMP weak Escherichia coli
1.7.1.7 AMP weak Klebsiella aerogenes
1.7.1.7 AMP weak Salmonella enterica subsp. enterica serovar Typhimurium
1.7.1.7 ATP
-
 Escherichia coli
1.7.1.7 ATP
-
 Klebsiella aerogenes
1.7.1.7 ATP
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.7.1.7 IMP
-
 Escherichia coli
1.7.1.7 IMP
-
 Klebsiella aerogenes
1.7.1.7 IMP
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.7.1.7 additional information not inhibited by KCN Escherichia coli
1.7.1.7 additional information not inhibited by KCN Klebsiella aerogenes
1.7.1.7 additional information not inhibited by KCN Salmonella enterica subsp. enterica serovar Typhimurium

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.7.1.7 0.096
-
 GMP
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.7.1.7 0.096
-
 GMP
-
 Escherichia coli
1.7.1.7 0.096
-
 GMP
-
 Klebsiella aerogenes

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.7.1.7 additional information no requirement for monovalent or divalent cations Salmonella enterica subsp. enterica serovar Typhimurium
1.7.1.7 additional information no requirement for monovalent or divalent cations Escherichia coli
1.7.1.7 additional information no requirement for monovalent or divalent cations Klebsiella aerogenes

Organism

EC Number Organism UniProt Comment Textmining
1.7.1.7 Escherichia coli
-
-
-
1.7.1.7 Klebsiella aerogenes
-
-
-
1.7.1.7 Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.7.1.7 additional information
-
 72.4 units/mg, 1 unit is defined as the amount of enzyme producing a decrease in absorbancy at 340 nm of 0.1 per min Salmonella enterica subsp. enterica serovar Typhimurium
1.7.1.7 additional information
-
 72.4 units/mg, 1 unit is defined as the amount of enzyme producing a decrease in absorbancy at 340 nm of 0.1 per min Escherichia coli
1.7.1.7 additional information
-
 72.4 units/mg, 1 unit is defined as the amount of enzyme producing a decrease in absorbancy at 340 nm of 0.1 per min Klebsiella aerogenes

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.7.1.7 NADPH + guanosine 5'-phosphate specific for GMP Salmonella enterica subsp. enterica serovar Typhimurium NADP+ + inosine 5'-phosphate + NH3
-
 ir
1.7.1.7 NADPH + guanosine 5'-phosphate specific for GMP Escherichia coli NADP+ + inosine 5'-phosphate + NH3
-
 ir
1.7.1.7 NADPH + guanosine 5'-phosphate specific for GMP Klebsiella aerogenes NADP+ + inosine 5'-phosphate + NH3
-
 ir

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.7.1.7 7.5 8.2
-
 Salmonella enterica subsp. enterica serovar Typhimurium
1.7.1.7 7.5 8.2
-
 Escherichia coli
1.7.1.7 7.5 8.2
-
 Klebsiella aerogenes

Cofactor

EC Number Cofactor Comment Organism Structure
1.7.1.7 NADPH specific for Salmonella enterica subsp. enterica serovar Typhimurium
1.7.1.7 NADPH specific for Escherichia coli
1.7.1.7 NADPH specific for Klebsiella aerogenes