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Literature summary extracted from

  • Umeki, S.
    Mechanisms for the activation/electron transfer of neutrophil NADPH-oxidase complex and molecular pathology of chronic granulomatous disease (1994), Ann. Hematol., 68, 267-277.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
1.6.3.1 Protein kinase C
-
 Homo sapiens

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.6.3.1 membrane
-
 Cavia porcellus 16020
-
1.6.3.1 membrane
-
 Sus scrofa 16020
-
1.6.3.1 membrane
-
 Bos taurus 16020
-
1.6.3.1 membrane subunit gp91-phox of cytochrome b558 of the multicomponent complex is an integral membrane protein with several membrane-spanning regions Homo sapiens 16020
-

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.6.3.1 NADPH + O2 Cavia porcellus
-
 NADP+ + O2-
-
 ?
1.6.3.1 NADPH + O2 Sus scrofa
-
 NADP+ + O2-
-
 ?
1.6.3.1 NADPH + O2 Bos taurus
-
 NADP+ + O2-
-
 ?
1.6.3.1 NADPH + O2 Homo sapiens part of defense mechanism against a wide variety of bacteria NADP+ + O2-
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.6.3.1 Bos taurus
-
-
-
1.6.3.1 Cavia porcellus
-
-
-
1.6.3.1 Homo sapiens
-
 multicomponent NADPH-oxidase consisting of a heterodimeric flavocytochrome b558, localized in the membrane and at least two cytosolic components p47-phox and p67-phox, enzyme plays a role in chronic granulomatous diseases, enzyme system is activated upon exposure to the appropriate stimuli leading to assembly in the plasma membrane of membrane-bound and cytosolic components
-
1.6.3.1 Sus scrofa
-
-
-

Posttranslational Modification

EC Number Posttranslational Modification Comment Organism
1.6.3.1 glycoprotein cytochrome b558 subunit gp91-phox of the multicomponent complex is heavily glycosylated Homo sapiens
1.6.3.1 side-chain modification phosphorylation of cytosolic component p47-phox Homo sapiens

Purification (Commentary)

EC Number Purification (Comment) Organism
1.6.3.1 cytochrome b558 and cytosolic components p47-phox and p67-phox Homo sapiens

Reaction

EC Number Reaction Comment Organism Reaction ID
1.6.3.1 NAD(P)H + H+ + O2 = NAD(P)+ + H2O2 model of electron transport from NADPH to the terminal electron acceptor O2 Homo sapiens
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.6.3.1 neutrophil
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.6.3.1 NADPH + O2
-
 Cavia porcellus NADP+ + O2-
-
 ?
1.6.3.1 NADPH + O2
-
 Homo sapiens NADP+ + O2-
-
 ?
1.6.3.1 NADPH + O2
-
 Sus scrofa NADP+ + O2-
-
 ?
1.6.3.1 NADPH + O2
-
 Bos taurus NADP+ + O2-
-
 ?
1.6.3.1 NADPH + O2 part of defense mechanism against a wide variety of bacteria Homo sapiens NADP+ + O2-
-
 ?

Subunits

EC Number Subunits Comment Organism
1.6.3.1 ? x * 47000-48000, p47-phox, cytosolic component of the multicomponent complex, SDS-PAGE Homo sapiens
1.6.3.1 ? x * 65000-67000, p67-phox, cytosolic component of the multicomponent complex, SDS-PAGE Homo sapiens
1.6.3.1 dimer 1 * 22000-23000 + 1 * 76000-91000, subunits of the membrane component of the enzyme complex, cytochrome b558, SDS-PAGE Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
1.6.3.1 FAD
-
 Cavia porcellus
1.6.3.1 FAD
-
 Sus scrofa
1.6.3.1 FAD
-
 Bos taurus
1.6.3.1 FAD cytochrome b558 of the multienzyme complex may contain FAD and heme Homo sapiens