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Literature summary extracted from

  • Moskovitz, J.; Bar-Noy, S.; Williams, W.M.; Requena, J.; Berlett, B.S.; Stadtman, E.R.
    Methionine sulfoxide reductase (MsrA) is a regulator of antioxidant defense and lifespan in mammals (2001), Proc. Natl. Acad. Sci. USA, 98, 12920-12925.
    View publication on PubMedView publication on EuropePMC

Protein Variants

EC Number Protein Variants Comment Organism
1.8.4.11 additional information generation of MsrA-deficient mutant mice, the mutant mice show tip-toe-walking, reduced lifespan under hyperoxic conditions and increased sensitivity to oxidative stress compared to wild-type mice, phenotype overview Mus musculus

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.8.4.11 L-methionine-(S)-S-oxide + thioredoxin Mus musculus stereospecific reduction L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 additional information Mus musculus MsrA is a regulator of antioxidant defense and lifespan in mammals ?
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin Mus musculus stereospecific reduction peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.8.4.11 Mus musculus
-
 C57BL76J mice, gene msrA
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.4.11 brain
-
 Mus musculus
-
1.8.4.11 kidney
-
 Mus musculus
-
1.8.4.11 liver
-
 Mus musculus
-
1.8.4.11 lung
-
 Mus musculus
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.4.11 additional information
-
 activities in wild-type and mutant mice in different organs during 2 days, overview Mus musculus

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.4.11 dabsyl-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Mus musculus dabsyl-L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction, free methionine-(S)-S-oxide Mus musculus L-methionine + thioredoxin disulfide + H2O
-
 ?
1.8.4.11 additional information MsrA is a regulator of antioxidant defense and lifespan in mammals Mus musculus ?
-
 ?
1.8.4.11 peptide-L-methionine-(S)-S-oxide + thioredoxin stereospecific reduction Mus musculus peptide-L-methionine + thioredoxin disulfide + H2O
-
 ?

Synonyms

EC Number Synonyms Comment Organism
1.8.4.11 methionine sulfoxide reductase
-
 Mus musculus
1.8.4.11 MsrA
-
 Mus musculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.4.11 thioredoxin
-
 Mus musculus