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Literature summary extracted from

  • Lash, L.H.; Jones, D.P.; Orrenius, S.
    The renal thiol (glutathione) oxidase. Subcellular localization and properties (1984), Biochim. Biophys. Acta, 779, 191-200.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.3.2 Bathocuproine disulfonate
-
 Rattus norvegicus
1.8.3.2 diethyldithiocarbamate
-
 Rattus norvegicus
1.8.3.2 EDTA milk enzyme Bos taurus
1.8.3.2 EDTA inhibition of enzyme from kidney and small intestine, no inhibition of enzyme from skin and seminal vesivles Rattus norvegicus
1.8.3.2 KCN
-
 Rattus norvegicus
1.8.3.2 L-(alphaS,5S)-alpha-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
-
 Rattus norvegicus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.3.2 0.25
-
 O2
-
 Rattus norvegicus
1.8.3.2 0.5
-
 GSH
-
 Rattus norvegicus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.3.2 cytosol
-
 Rattus norvegicus 5829
-
1.8.3.2 plasma membrane associated to basal-lateral region of the plasma membrane Rattus norvegicus 5886
-
1.8.3.2 vesicular fraction
-
 Bos taurus
-
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.3.2 copper enzyme from kindney and small intestine Rattus norvegicus
1.8.3.2 Iron
-
 Bos taurus

Organism

EC Number Organism UniProt Comment Textmining
1.8.3.2 Bos taurus
-
-
-
1.8.3.2 Rattus norvegicus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.3.2 kidney
-
 Rattus norvegicus
-
1.8.3.2 milk
-
 Rattus norvegicus
-
1.8.3.2 milk
-
 Bos taurus
-
1.8.3.2 seminal vesicle
-
 Rattus norvegicus
-
1.8.3.2 skin
-
 Rattus norvegicus
-
1.8.3.2 small intestine
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.3.2 dithiothreitol + O2
-
 Rattus norvegicus ? + H2O
-
 ?
1.8.3.2 GSH + O2 + O2
-
 Rattus norvegicus GSSG + H2O
-
 ?
1.8.3.2 GSH + O2 + O2
-
 Bos taurus GSSG + H2O
-
 ?
1.8.3.2 L-Cys + O2
-
 Rattus norvegicus ? + H2O
-
 ?
1.8.3.2 L-Cys + O2
-
 Bos taurus ? + H2O
-
 ?
1.8.3.2 N-acetylcysteine + O2
-
 Rattus norvegicus ? + H2O
-
 ?
1.8.3.2 N-acetylcysteine + O2
-
 Bos taurus ? + H2O
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.8.3.2 7.4
-
-
 Rattus norvegicus

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.3.2 FAD enzyme from seminal vesicles Rattus norvegicus