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Literature summary extracted from

  • Lash, L.H.; Jones, D.P.
    Purification and properties of the membranal thiol oxidase from porcine kidney (1986), Arch. Biochem. Biophys., 247, 120-130.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.3.2 H2O2
-
Sus scrofa
1.8.3.2 L-(alphaS,5S)-alpha-Amino-3-chloro-4,5-dihydro-5-isoxazoleacetic acid
-
Sus scrofa
1.8.3.2 NEM
-
Sus scrofa

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.3.2 0.42
-
L-Cys
-
Sus scrofa
1.8.3.2 0.51
-
dithiothreitol
-
Sus scrofa
1.8.3.2 0.73
-
GSH
-
Sus scrofa
1.8.3.2 1.6
-
cysteamine
-
Sus scrofa
1.8.3.2 3.3
-
N-acetylcysteine
-
Sus scrofa

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
1.8.3.2 plasma membrane
-
Sus scrofa 5886
-

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.3.2 copper contains 1 mol copper per subunit, in a binuclear complex Sus scrofa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.8.3.2 70000
-
2 * 70000, also aggregates to larger multimers, SDS-PAGE Sus scrofa
1.8.3.2 120000
-
gel filtration Sus scrofa

Organism

EC Number Organism UniProt Comment Textmining
1.8.3.2 Sus scrofa
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.8.3.2
-
Sus scrofa

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.8.3.2 kidney cortex Sus scrofa
-

Specific Activity [micromol/min/mg]

EC Number Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
1.8.3.2 additional information
-
-
Sus scrofa

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.3.2 cysteamine + O2
-
Sus scrofa ? + H2O
-
?
1.8.3.2 dithiothreitol + O2
-
Sus scrofa ? + H2O
-
?
1.8.3.2 GSH + O2 + O2
-
Sus scrofa GSSG + H2O
-
?
1.8.3.2 L-Cys + O2
-
Sus scrofa ? + H2O
-
?
1.8.3.2 N-acetylcysteine + O2
-
Sus scrofa ? + H2O
-
?

Subunits

EC Number Subunits Comment Organism
1.8.3.2 dimer 2 * 70000, also aggregates to larger multimers, SDS-PAGE Sus scrofa