BRENDA - Enzyme Database show

Molybdenum iron-sulfur flavin hydroxylases and related enzymes

Bray, R.C.; The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ) 12, 299-419 (1975)
No PubMed abstract available

Data extracted from this reference:

Inhibitors
EC Number
Inhibitors
Commentary
Organism
Structure
1.8.3.1
arsenite
-
Oryctolagus cuniculus
1.8.3.1
arsenite
-
Sus scrofa
1.8.3.1
arsenite
-
Gallus gallus
1.8.3.1
arsenite
-
Rattus norvegicus
1.8.3.1
arsenite
-
Bos taurus
1.8.3.1
CN-
-
Gallus gallus
1.8.3.1
CN-
-
Oryctolagus cuniculus
1.8.3.1
CN-
-
Rattus norvegicus
1.8.3.1
CN-
-
Sus scrofa
1.8.3.1
CN-
-
Bos taurus
1.17.3.2
2,4-Diamino-6-hydroxy-s-triazine
-
Bos taurus
1.17.3.2
2,4-dinitrofluorobenzene
-
Bos taurus
1.17.3.2
2-Amino-4-hydroxypterine-6-aldehyde
-
Bos taurus
1.17.3.2
allopurinol
-
Bos taurus
1.17.3.2
arsenite
-
Bos taurus
1.17.3.2
cyanide
-
Bos taurus
1.17.3.2
cyanide
-
Gallus gallus
1.17.3.2
formaldehyde
-
Bos taurus
1.17.3.2
guanine
-
Bos taurus
1.17.3.2
methanol
-
Gallus gallus
1.17.3.2
methanol
-
Bos taurus
1.17.3.2
Purine-6-aldehyde
-
Bos taurus
1.17.3.2
salicylate
-
Bos taurus
1.17.3.2
thiocyanate
-
Drosophila melanogaster
1.17.3.2
thiocyanate
-
Gallus gallus
1.17.3.2
Urea
-
Bos taurus
KM Value [mM]
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.8.3.1
0.002
-
cytochrome c
-
Gallus gallus
1.8.3.1
0.002
-
cytochrome c
-
Rattus norvegicus
1.8.3.1
0.39
-
sulfite
-
Bos taurus
1.17.3.2
additional information
-
additional information
-
Bos taurus
1.17.3.2
additional information
-
additional information
-
Drosophila melanogaster
1.17.3.2
0.05
-
O2
cosubstrate xanthine, pH 8.5
Bos taurus
1.17.3.2
0.08
-
O2
cosubstrate xanthine, pH 10.0
Bos taurus
Localization
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.8.3.1
mitochondrion
-
Gallus gallus
5739
-
1.8.3.1
mitochondrion
-
Oryctolagus cuniculus
5739
-
1.8.3.1
mitochondrion
-
Sus scrofa
5739
-
1.8.3.1
mitochondrion
-
Bos taurus
5739
-
1.8.3.1
mitochondrion
-
Rattus norvegicus
5739
-
Metals/Ions
EC Number
Metals/Ions
Commentary
Organism
Structure
1.8.3.1
Mo
-
Bos taurus
1.8.3.1
Mo
-
Oryctolagus cuniculus
1.8.3.1
Mo
-
Sus scrofa
1.8.3.1
Mo
-
Rattus norvegicus
1.8.3.1
Mo
-
Gallus gallus
1.17.3.2
Iron
contains FAD, iron and molybdenum in the ratio 1/4/4; iron-molybdenum protein
Drosophila melanogaster
1.17.3.2
Iron
contains FAD, iron and molybdenum in the ratio 1/4/4; iron-molybdenum protein
Gallus gallus
1.17.3.2
Iron
contains FAD, iron and molybdenum in the ratio 1/4/4; iron-molybdenum protein
Bos taurus
1.17.3.2
Molybdenum
an iron-molybdenum protein; contains FAD, molybdenum and iron in the ratio 1/4/4
Drosophila melanogaster
1.17.3.2
Molybdenum
an iron-molybdenum protein; contains FAD, molybdenum and iron in the ratio 1/4/4
Gallus gallus
1.17.3.2
Molybdenum
an iron-molybdenum protein; contains FAD, molybdenum and iron in the ratio 1/4/4
Bos taurus
Molecular Weight [Da]
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.17.3.2
additional information
-
-
Bos taurus
1.17.3.2
additional information
-
-
Gallus gallus
1.17.3.2
120000
-
2 * 120000
Gallus gallus
1.17.3.2
150000
-
2 * 150000, SDS-PAGE
Bos taurus
Organism
EC Number
Organism
Primary Accession No. (UniProt)
Commentary
Textmining
1.8.3.1
Bos taurus
-
-
-
1.8.3.1
Gallus gallus
-
-
-
1.8.3.1
Oryctolagus cuniculus
-
-
-
1.8.3.1
Rattus norvegicus
-
-
-
1.8.3.1
Sus scrofa
-
-
-
1.17.3.2
Bos taurus
-
-
-
1.17.3.2
Drosophila melanogaster
-
-
-
1.17.3.2
Gallus gallus
-
-
-
Posttranslational Modification
EC Number
Posttranslational Modification
Commentary
Organism
1.17.3.2
additional information
-
Drosophila melanogaster
1.17.3.2
additional information
-
Gallus gallus
1.17.3.2
additional information
-
Bos taurus
1.17.3.2
proteolytic modification
-
Drosophila melanogaster
1.17.3.2
proteolytic modification
-
Gallus gallus
1.17.3.2
proteolytic modification
-
Bos taurus
Purification (Commentary)
EC Number
Commentary
Organism
1.8.3.1
-
Oryctolagus cuniculus
1.8.3.1
-
Sus scrofa
1.8.3.1
-
Bos taurus
1.8.3.1
-
Rattus norvegicus
1.8.3.1
-
Gallus gallus
Reaction
EC Number
Reaction
Commentary
Organism
1.17.3.2
xanthine + H2O + O2 = urate + H2O2
mechanism
Bos taurus
Source Tissue
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.3.1
additional information
-
Gallus gallus
-
1.8.3.1
additional information
-
Oryctolagus cuniculus
-
1.8.3.1
additional information
-
Sus scrofa
-
1.8.3.1
additional information
-
Rattus norvegicus
-
1.17.3.2
liver
-
Bos taurus
-
1.17.3.2
liver
-
Gallus gallus
-
1.17.3.2
milk
-
Bos taurus
-
Specific Activity [micromol/min/mg]
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
1.8.3.1
additional information
-
-
Bos taurus
1.8.3.1
additional information
-
-
Gallus gallus
1.8.3.1
additional information
-
-
Oryctolagus cuniculus
1.8.3.1
additional information
-
-
Rattus norvegicus
1.8.3.1
additional information
-
-
Sus scrofa
1.17.3.2
2.4
5.1
-
Bos taurus
Substrates and Products (Substrate)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.3.1
sulfite + cytochrome c
-
393008
Gallus gallus
sulfate + reduced cytochrome c
-
-
-
-
1.8.3.1
sulfite + cytochrome c
-
393008
Rattus norvegicus
sulfate + reduced cytochrome c
-
-
-
-
1.8.3.1
sulfite + H2O + A
-
393008
Bos taurus
SO42- + AH2
-
-
-
-
1.17.3.2
1-methyl-2-hydroxypurine + H2O + O2
-
393008
Bos taurus
1-methyl-2-hydroxy-7,9-dihydropurin-8-one + H2O2
-
393008
Bos taurus
?
1.17.3.2
1-methylxanthine + H2O + O2
-
393008
Bos taurus
1-methylurate + H2O2
-
393008
Bos taurus
?
1.17.3.2
3-methylhypoxanthine + H2O + O2
-
393008
Bos taurus
3-methylxanthine + H2O2
-
393008
Bos taurus
?
1.17.3.2
6,8-dihydroxypurine + H2O + O2
-
393008
Bos taurus
?
-
-
-
?
1.17.3.2
6-cyanopurine + H2O + O2
-
393008
Bos taurus
6-cyano-7,9-dihydropurine-8-one
-
393008
Bos taurus
?
1.17.3.2
6-thioxanthine + H2O + O2
-
393008
Bos taurus
6-thiourate + H2O2
-
393008
Bos taurus
?
1.17.3.2
acetaldehyde + H2O + O2
-
393008
Bos taurus
acetic acid + H2O2
-
393008
Bos taurus
?
1.17.3.2
adenine + H2O + O2
-
393008
Bos taurus
6-amino-7,9-dihydropurin-8-one + H2O2
-
393008
Bos taurus
?
1.17.3.2
allopurinol + H2O + O2
-
393008
Bos taurus
?
-
-
-
?
1.17.3.2
hypoxanthine + 2 H2O + 2 O2
-
393008
Gallus gallus
urate + 2 H2O2
-
393008
Gallus gallus
?
1.17.3.2
hypoxanthine + 2 H2O + 2 O2
-
393008
Drosophila melanogaster
urate + 2 H2O2
-
393008
Drosophila melanogaster
?
1.17.3.2
hypoxanthine + 2 H2O + 2 O2
-
393008
Bos taurus
urate + 2 H2O2
-
393008
Bos taurus
?
1.17.3.2
N1-methylnicotinamide + H2O + O2
-
393008
Bos taurus
?
-
-
-
-
1.17.3.2
NADH + H2O + O2
-
393008
Bos taurus
NAD+ + H2O2
-
393008
Bos taurus
?
1.17.3.2
pteridine + H2O + O2
and derivatives, e.g.: 4-amino-7-hydroxy pteridine, 4-hydroxy-7-azapteridine
393008
Bos taurus
?
-
-
-
?
1.17.3.2
purine + H2O + O2
purine and derivatives
393008
Bos taurus
7,9-dihydropurin-8-one + H2O2
-
393008
Bos taurus
?
1.17.3.2
pyrimidine derivatives + H2O + O2
e.g. 2-hydroxypyrimidine
393008
Bos taurus
?
-
-
-
?
1.17.3.2
pyrimidine derivatives + H2O + O2
6-hydroxy-6-aminepyrimidine
393008
Bos taurus
?
-
-
-
?
1.17.3.2
pyrimidine derivatives + H2O + O2
7-hydroxy-(1,2,5)-thiadiazolo(3,4-d)-pyrimidine
393008
Gallus gallus
?
-
-
-
?
1.17.3.2
pyrimidine derivatives + H2O + O2
7-hydroxy-(1,2,5)-thiadiazolo(3,4-d)-pyrimidine
393008
Drosophila melanogaster
?
-
-
-
?
1.17.3.2
salicylaldehyde + H2O + O2
-
393008
Bos taurus
salicylic acid + H2O2
-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor methylene blue
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor NAD+
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor O2
393008
Gallus gallus
uric acid + H2O2
-
393008
Gallus gallus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor O2
393008
Drosophila melanogaster
uric acid + H2O2
-
393008
Drosophila melanogaster
?
1.17.3.2
xanthine + H2O + O2
electron acceptor O2
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor quinones
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
specificity for electron acceptor is low
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
enzyme also oxidizes hypoxanthine, some other purines, pterines and aldehydes, i.e. possesses the activity of EC 1.2.3.1, probably acts on the hydrated derivatives of these substrates
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
low specificity to substrate
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor ferricyanide
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor 2,6-dichlorophenolindophenol
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
Subunits
EC Number
Subunits
Commentary
Organism
1.17.3.2
dimer
2 * 130000-140000
Drosophila melanogaster
1.17.3.2
dimer
2 * 120000
Gallus gallus
1.17.3.2
dimer
2 * 150000, SDS-PAGE
Bos taurus
Turnover Number [1/s]
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1.17.3.2
16.2
-
xanthine
pH 8.2, 23.5░C
Bos taurus
pH Optimum
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.8.3.1
8.6
-
with O2 as acceptor
Bos taurus
1.17.3.2
8.3
-
-
Bos taurus
Cofactor
EC Number
Cofactor
Commentary
Organism
Structure
1.8.3.1
heme
-
Oryctolagus cuniculus
1.8.3.1
heme
-
Rattus norvegicus
1.8.3.1
heme
-
Sus scrofa
1.8.3.1
heme
-
Gallus gallus
1.8.3.1
heme
-
Bos taurus
1.17.3.2
FAD
contains FAD, molybdenum and iron in the ratio 1 : 4 : 4; flavoprotein
Drosophila melanogaster
1.17.3.2
FAD
contains FAD, molybdenum and iron in the ratio 1 : 4 : 4; flavoprotein
Gallus gallus
1.17.3.2
FAD
contains FAD, molybdenum and iron in the ratio 1 : 4 : 4; flavoprotein
Bos taurus
Cofactor (protein specific)
EC Number
Cofactor
Commentary
Organism
Structure
1.8.3.1
heme
-
Oryctolagus cuniculus
1.8.3.1
heme
-
Rattus norvegicus
1.8.3.1
heme
-
Sus scrofa
1.8.3.1
heme
-
Gallus gallus
1.8.3.1
heme
-
Bos taurus
1.17.3.2
FAD
contains FAD, molybdenum and iron in the ratio 1 : 4 : 4; flavoprotein
Drosophila melanogaster
1.17.3.2
FAD
contains FAD, molybdenum and iron in the ratio 1 : 4 : 4; flavoprotein
Gallus gallus
1.17.3.2
FAD
contains FAD, molybdenum and iron in the ratio 1 : 4 : 4; flavoprotein
Bos taurus
Inhibitors (protein specific)
EC Number
Inhibitors
Commentary
Organism
Structure
1.8.3.1
arsenite
-
Oryctolagus cuniculus
1.8.3.1
arsenite
-
Sus scrofa
1.8.3.1
arsenite
-
Gallus gallus
1.8.3.1
arsenite
-
Rattus norvegicus
1.8.3.1
arsenite
-
Bos taurus
1.8.3.1
CN-
-
Gallus gallus
1.8.3.1
CN-
-
Oryctolagus cuniculus
1.8.3.1
CN-
-
Rattus norvegicus
1.8.3.1
CN-
-
Sus scrofa
1.8.3.1
CN-
-
Bos taurus
1.17.3.2
2,4-Diamino-6-hydroxy-s-triazine
-
Bos taurus
1.17.3.2
2,4-dinitrofluorobenzene
-
Bos taurus
1.17.3.2
2-Amino-4-hydroxypterine-6-aldehyde
-
Bos taurus
1.17.3.2
allopurinol
-
Bos taurus
1.17.3.2
arsenite
-
Bos taurus
1.17.3.2
cyanide
-
Bos taurus
1.17.3.2
cyanide
-
Gallus gallus
1.17.3.2
formaldehyde
-
Bos taurus
1.17.3.2
guanine
-
Bos taurus
1.17.3.2
methanol
-
Gallus gallus
1.17.3.2
methanol
-
Bos taurus
1.17.3.2
Purine-6-aldehyde
-
Bos taurus
1.17.3.2
salicylate
-
Bos taurus
1.17.3.2
thiocyanate
-
Drosophila melanogaster
1.17.3.2
thiocyanate
-
Gallus gallus
1.17.3.2
Urea
-
Bos taurus
KM Value [mM] (protein specific)
EC Number
KM Value [mM]
KM Value Maximum [mM]
Substrate
Commentary
Organism
Structure
1.8.3.1
0.002
-
cytochrome c
-
Gallus gallus
1.8.3.1
0.002
-
cytochrome c
-
Rattus norvegicus
1.8.3.1
0.39
-
sulfite
-
Bos taurus
1.17.3.2
additional information
-
additional information
-
Bos taurus
1.17.3.2
additional information
-
additional information
-
Drosophila melanogaster
1.17.3.2
0.05
-
O2
cosubstrate xanthine, pH 8.5
Bos taurus
1.17.3.2
0.08
-
O2
cosubstrate xanthine, pH 10.0
Bos taurus
Localization (protein specific)
EC Number
Localization
Commentary
Organism
GeneOntology No.
Textmining
1.8.3.1
mitochondrion
-
Gallus gallus
5739
-
1.8.3.1
mitochondrion
-
Oryctolagus cuniculus
5739
-
1.8.3.1
mitochondrion
-
Sus scrofa
5739
-
1.8.3.1
mitochondrion
-
Bos taurus
5739
-
1.8.3.1
mitochondrion
-
Rattus norvegicus
5739
-
Metals/Ions (protein specific)
EC Number
Metals/Ions
Commentary
Organism
Structure
1.8.3.1
Mo
-
Bos taurus
1.8.3.1
Mo
-
Oryctolagus cuniculus
1.8.3.1
Mo
-
Sus scrofa
1.8.3.1
Mo
-
Rattus norvegicus
1.8.3.1
Mo
-
Gallus gallus
1.17.3.2
Iron
contains FAD, iron and molybdenum in the ratio 1/4/4; iron-molybdenum protein
Drosophila melanogaster
1.17.3.2
Iron
contains FAD, iron and molybdenum in the ratio 1/4/4; iron-molybdenum protein
Gallus gallus
1.17.3.2
Iron
contains FAD, iron and molybdenum in the ratio 1/4/4; iron-molybdenum protein
Bos taurus
1.17.3.2
Molybdenum
an iron-molybdenum protein; contains FAD, molybdenum and iron in the ratio 1/4/4
Drosophila melanogaster
1.17.3.2
Molybdenum
an iron-molybdenum protein; contains FAD, molybdenum and iron in the ratio 1/4/4
Gallus gallus
1.17.3.2
Molybdenum
an iron-molybdenum protein; contains FAD, molybdenum and iron in the ratio 1/4/4
Bos taurus
Molecular Weight [Da] (protein specific)
EC Number
Molecular Weight [Da]
Molecular Weight Maximum [Da]
Commentary
Organism
1.17.3.2
additional information
-
-
Bos taurus
1.17.3.2
additional information
-
-
Gallus gallus
1.17.3.2
120000
-
2 * 120000
Gallus gallus
1.17.3.2
150000
-
2 * 150000, SDS-PAGE
Bos taurus
Posttranslational Modification (protein specific)
EC Number
Posttranslational Modification
Commentary
Organism
1.17.3.2
additional information
-
Drosophila melanogaster
1.17.3.2
additional information
-
Gallus gallus
1.17.3.2
additional information
-
Bos taurus
1.17.3.2
proteolytic modification
-
Drosophila melanogaster
1.17.3.2
proteolytic modification
-
Gallus gallus
1.17.3.2
proteolytic modification
-
Bos taurus
Purification (Commentary) (protein specific)
EC Number
Commentary
Organism
1.8.3.1
-
Oryctolagus cuniculus
1.8.3.1
-
Sus scrofa
1.8.3.1
-
Bos taurus
1.8.3.1
-
Rattus norvegicus
1.8.3.1
-
Gallus gallus
Source Tissue (protein specific)
EC Number
Source Tissue
Commentary
Organism
Textmining
1.8.3.1
additional information
-
Gallus gallus
-
1.8.3.1
additional information
-
Oryctolagus cuniculus
-
1.8.3.1
additional information
-
Sus scrofa
-
1.8.3.1
additional information
-
Rattus norvegicus
-
1.17.3.2
liver
-
Bos taurus
-
1.17.3.2
liver
-
Gallus gallus
-
1.17.3.2
milk
-
Bos taurus
-
Specific Activity [micromol/min/mg] (protein specific)
EC Number
Specific Activity Minimum [Ámol/min/mg]
Specific Activity Maximum [Ámol/min/mg]
Commentary
Organism
1.8.3.1
additional information
-
-
Bos taurus
1.8.3.1
additional information
-
-
Gallus gallus
1.8.3.1
additional information
-
-
Oryctolagus cuniculus
1.8.3.1
additional information
-
-
Rattus norvegicus
1.8.3.1
additional information
-
-
Sus scrofa
1.17.3.2
2.4
5.1
-
Bos taurus
Substrates and Products (Substrate) (protein specific)
EC Number
Substrates
Commentary Substrates
Literature (Substrates)
Organism
Products
Commentary (Products)
Literature (Products)
Organism (Products)
Reversibility
1.8.3.1
sulfite + cytochrome c
-
393008
Gallus gallus
sulfate + reduced cytochrome c
-
-
-
-
1.8.3.1
sulfite + cytochrome c
-
393008
Rattus norvegicus
sulfate + reduced cytochrome c
-
-
-
-
1.8.3.1
sulfite + H2O + A
-
393008
Bos taurus
SO42- + AH2
-
-
-
-
1.17.3.2
1-methyl-2-hydroxypurine + H2O + O2
-
393008
Bos taurus
1-methyl-2-hydroxy-7,9-dihydropurin-8-one + H2O2
-
393008
Bos taurus
?
1.17.3.2
1-methylxanthine + H2O + O2
-
393008
Bos taurus
1-methylurate + H2O2
-
393008
Bos taurus
?
1.17.3.2
3-methylhypoxanthine + H2O + O2
-
393008
Bos taurus
3-methylxanthine + H2O2
-
393008
Bos taurus
?
1.17.3.2
6,8-dihydroxypurine + H2O + O2
-
393008
Bos taurus
?
-
-
-
?
1.17.3.2
6-cyanopurine + H2O + O2
-
393008
Bos taurus
6-cyano-7,9-dihydropurine-8-one
-
393008
Bos taurus
?
1.17.3.2
6-thioxanthine + H2O + O2
-
393008
Bos taurus
6-thiourate + H2O2
-
393008
Bos taurus
?
1.17.3.2
acetaldehyde + H2O + O2
-
393008
Bos taurus
acetic acid + H2O2
-
393008
Bos taurus
?
1.17.3.2
adenine + H2O + O2
-
393008
Bos taurus
6-amino-7,9-dihydropurin-8-one + H2O2
-
393008
Bos taurus
?
1.17.3.2
allopurinol + H2O + O2
-
393008
Bos taurus
?
-
-
-
?
1.17.3.2
hypoxanthine + 2 H2O + 2 O2
-
393008
Gallus gallus
urate + 2 H2O2
-
393008
Gallus gallus
?
1.17.3.2
hypoxanthine + 2 H2O + 2 O2
-
393008
Drosophila melanogaster
urate + 2 H2O2
-
393008
Drosophila melanogaster
?
1.17.3.2
hypoxanthine + 2 H2O + 2 O2
-
393008
Bos taurus
urate + 2 H2O2
-
393008
Bos taurus
?
1.17.3.2
N1-methylnicotinamide + H2O + O2
-
393008
Bos taurus
?
-
-
-
-
1.17.3.2
NADH + H2O + O2
-
393008
Bos taurus
NAD+ + H2O2
-
393008
Bos taurus
?
1.17.3.2
pteridine + H2O + O2
and derivatives, e.g.: 4-amino-7-hydroxy pteridine, 4-hydroxy-7-azapteridine
393008
Bos taurus
?
-
-
-
?
1.17.3.2
purine + H2O + O2
purine and derivatives
393008
Bos taurus
7,9-dihydropurin-8-one + H2O2
-
393008
Bos taurus
?
1.17.3.2
pyrimidine derivatives + H2O + O2
e.g. 2-hydroxypyrimidine
393008
Bos taurus
?
-
-
-
?
1.17.3.2
pyrimidine derivatives + H2O + O2
6-hydroxy-6-aminepyrimidine
393008
Bos taurus
?
-
-
-
?
1.17.3.2
pyrimidine derivatives + H2O + O2
7-hydroxy-(1,2,5)-thiadiazolo(3,4-d)-pyrimidine
393008
Gallus gallus
?
-
-
-
?
1.17.3.2
pyrimidine derivatives + H2O + O2
7-hydroxy-(1,2,5)-thiadiazolo(3,4-d)-pyrimidine
393008
Drosophila melanogaster
?
-
-
-
?
1.17.3.2
salicylaldehyde + H2O + O2
-
393008
Bos taurus
salicylic acid + H2O2
-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor methylene blue
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor NAD+
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor O2
393008
Gallus gallus
uric acid + H2O2
-
393008
Gallus gallus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor O2
393008
Drosophila melanogaster
uric acid + H2O2
-
393008
Drosophila melanogaster
?
1.17.3.2
xanthine + H2O + O2
electron acceptor O2
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor quinones
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
specificity for electron acceptor is low
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
enzyme also oxidizes hypoxanthine, some other purines, pterines and aldehydes, i.e. possesses the activity of EC 1.2.3.1, probably acts on the hydrated derivatives of these substrates
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
low specificity to substrate
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor ferricyanide
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
1.17.3.2
xanthine + H2O + O2
electron acceptor 2,6-dichlorophenolindophenol
393008
Bos taurus
uric acid + H2O2
under some conditions the product is mainly superoxide rather than peroxide: RH + H2O + 2 O2 = ROH + 2 H+ + 2 O2-
393008
Bos taurus
?
Subunits (protein specific)
EC Number
Subunits
Commentary
Organism
1.17.3.2
dimer
2 * 130000-140000
Drosophila melanogaster
1.17.3.2
dimer
2 * 120000
Gallus gallus
1.17.3.2
dimer
2 * 150000, SDS-PAGE
Bos taurus
Turnover Number [1/s] (protein specific)
EC Number
Turnover Number Minimum [1/s]
Turnover Number Maximum [1/s]
Substrate
Commentary
Organism
Structure
1.17.3.2
16.2
-
xanthine
pH 8.2, 23.5░C
Bos taurus
pH Optimum (protein specific)
EC Number
pH Optimum Minimum
pH Optimum Maximum
Commentary
Organism
1.8.3.1
8.6
-
with O2 as acceptor
Bos taurus
1.17.3.2
8.3
-
-
Bos taurus