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Literature summary extracted from

  • Siegel, L.M.; Rueger, D.C.; Barber, M.J.; Krueger, R.J.; Orme-Johnson, N.R.; Orme-Johnson, W.H.
    Escherichia coli sulfite reductase hemoprotein subunit. Prosthetic groups, catalytic parameters, and ligand complexes (1982), J. Biol. Chem., 257, 6343-6350.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.8.1.2 CN-
-
 Escherichia coli
1.8.1.2 CO
-
 Escherichia coli

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.8.1.2 0.012 0.017 sulfite
-
 Escherichia coli
1.8.1.2 0.8 1.5 nitrite
-
 Escherichia coli
1.8.1.2 4.5 10.5 hydroxylamine
-
 Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
1.8.1.2 Iron-sulfur cluster hemoprotein subunit contains one siroheme and one Fe4S4 center per polypeptide, heme is in high spin Fe3+ state Escherichia coli

Organism

EC Number Organism UniProt Comment Textmining
1.8.1.2 Escherichia coli
-
-
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.8.1.2 hydroxylamine + NADPH
-
 Escherichia coli ammonia + NADP+
-
 ?
1.8.1.2 additional information reduction of sulfite, nitrite, and hydroxylamine by NADPH requires catalytic activities of both subunits, reduction of sulfite, nitrite, and hydroxylamine by methyl viologen requires hemoprotein subunit Escherichia coli ?
-
 ?
1.8.1.2 nitrite + NADPH NADPH can be replaced by reduced methyl viologen, the latter reaction is catalyzed by hemoprotein subunit alone Escherichia coli ammonia + NADP+
-
 ?
1.8.1.2 sulfite + NADPH NADPH can be replaced by reduced methyl viologen Escherichia coli sulfide + NADP+ + H2O
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
1.8.1.2 heme hemoprotein subunit contains one siroheme and one Fe4S4 center per polypeptide Escherichia coli