Any feedback?
Literature summary extracted from
- Inhibition by capsaicin of NADH-quinone oxidoreductase is correlated with the presence of energy-coupling site 1 in various organisms (1990), Arch. Biochem. Biophys., 281, 305-311.
Inhibitors
| EC Number | Inhibitors | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | capsaicin | no inhibition of enzymes where the energy couling site is absent | Bacillus subtilis |  |
| 7.1.1.2 | capsaicin | inhibition of enzymes involved in energy coupling site | Bos taurus | |
| 7.1.1.2 | capsaicin | inhibition of enzymes involved in energy coupling site | Escherichia coli | |
| 7.1.1.2 | capsaicin | inhibition of enzymes involved in energy coupling site | Paracoccus denitrificans | |
| 7.1.1.2 | capsaicin | no inhibition of enzymes where the energy couling site is absent | Saccharomyces cerevisiae | |
| 7.1.1.2 | capsaicin | inhibition of enzymes involved in energy coupling site | Thermus thermophilus | |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.1.1.2 | membrane | - |
Paracoccus denitrificans | 16020 | - |
| 7.1.1.2 | membrane | - |
Bacillus subtilis | 16020 | - |
| 7.1.1.2 | membrane | - |
Thermus thermophilus | 16020 | - |
| 7.1.1.2 | membrane | - |
Escherichia coli | 16020 | - |
| 7.1.1.2 | membrane | - |
Saccharomyces cerevisiae | 16020 | - |
| 7.1.1.2 | mitochondrion | - |
Thermus thermophilus | 5739 | - |
| 7.1.1.2 | mitochondrion | - |
Saccharomyces cerevisiae | 5739 | - |
| 7.1.1.2 | mitochondrion | - |
Bos taurus | 5739 | - |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.1.1.2 | Bacillus subtilis | - |
- |
- |
| 7.1.1.2 | Bos taurus | - |
- |
- |
| 7.1.1.2 | Escherichia coli | - |
- |
- |
| 7.1.1.2 | Paracoccus denitrificans | - |
- |
- |
| 7.1.1.2 | Saccharomyces cerevisiae | - |
- |
- |
| 7.1.1.2 | Thermus thermophilus | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 7.1.1.2 | heart | - |
Bos taurus | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.1.1.2 | NADH + ubiquinone | - |
Paracoccus denitrificans | NAD+ + ubiquinol | - |
? | |
| 7.1.1.2 | NADH + ubiquinone | - |
Bacillus subtilis | NAD+ + ubiquinol | - |
? | |
| 7.1.1.2 | NADH + ubiquinone | - |
Thermus thermophilus | NAD+ + ubiquinol | - |
? | |
| 7.1.1.2 | NADH + ubiquinone | - |
Escherichia coli | NAD+ + ubiquinol | - |
? | |
| 7.1.1.2 | NADH + ubiquinone | - |
Saccharomyces cerevisiae | NAD+ + ubiquinol | - |
? | |
| 7.1.1.2 | NADH + ubiquinone | - |
Bos taurus | NAD+ + ubiquinol | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 7.1.1.2 | More | - |
Paracoccus denitrificans |
| 7.1.1.2 | More | - |
Escherichia coli |
| 7.1.1.2 | More | - |
Bos taurus |
| 7.1.1.2 | More | enzyme complex is composed of approximately 10 unlike polypeptides, the NADH-binding subunit has a MW of 47000 Da determined by SDS-PAGE | Thermus thermophilus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | FMN | - |
Paracoccus denitrificans | |
| 7.1.1.2 | FMN | - |
Thermus thermophilus | |
| 7.1.1.2 | FMN | - |
Bos taurus | |
| 7.1.1.2 | NADH | - |
Paracoccus denitrificans | |
| 7.1.1.2 | NADH | - |
Bacillus subtilis | |
| 7.1.1.2 | NADH | - |
Thermus thermophilus | |
| 7.1.1.2 | NADH | - |
Escherichia coli | |
| 7.1.1.2 | NADH | - |
Saccharomyces cerevisiae | |
| 7.1.1.2 | NADH | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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