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Literature summary extracted from
- The proton-translocating NADH-quinone oxidoreductase (NDH-1) of the thermophilic bacterium Thermus thermophilus HB-8 (1997), J. Biol. Chem., 272, 4201-4211.
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 7.1.1.2 | NQO2 subunit expressed in Escherichia coli | Thermus thermophilus |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 7.1.1.2 | mitochondrion | - |
Thermus thermophilus | 5739 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | Iron | the enzyme contains at most nine putative iron-sulfur cluster binding sites, the NQO2 subunit bears a single [2Fe-2S] cluster, the NQO3 subunit contains multiple iron-sulfur clusters: one [2Fe-2S] cluster, one [4Fe-4S] cluster and possibly another [4Fe-4S] cluster | Thermus thermophilus |  |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.1.1.2 | NADH + ubiquinone | Thermus thermophilus | proton-translocating enzyme | ? | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 7.1.1.2 | Thermus thermophilus | - |
HB-8 | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 7.1.1.2 | NADH + ubiquinone | proton-translocating enzyme | Thermus thermophilus | NAD+ + ubiquinol | - |
? | |
| 7.1.1.2 | NADH + ubiquinone | proton-translocating enzyme | Thermus thermophilus | ? | - |
? | |
Synonyms
| EC Number | Synonyms | Comment | Organism |
|---|---|---|---|
| 7.1.1.2 | NADH-quinone oxidoreductase | - |
Thermus thermophilus |
| 7.1.1.2 | NDH-1 | - |
Thermus thermophilus |
| 7.1.1.2 | proton-translocating NADH-quinone oxidoreductase | - |
Thermus thermophilus |
Temperature Stability [°C]
| EC Number | Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|---|
| 7.1.1.2 | 65 | - |
3 h, Fe-S cluster remains intact | Thermus thermophilus |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 7.1.1.2 | NADH | - |
Thermus thermophilus | |
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