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Literature summary extracted from

  • Grivennikova, V.G.; Kapustin, A.N.; Vinogradov, A.D.
    Catalytic activity of NADH-ubiquinone oxidoreductase (complex I) in intact mitochondria: evidence for the slow active/inactive transition (2001), J. Biol. Chem., 276, 9038-9044.
    View publication on PubMed

Activating Compound

EC Number Activating Compound Comment Organism Structure
7.1.1.2 additional information brief exposure of the thermally deactivated mitochondria with malate/glutamate, NAD+ and cytochrome c induced reactivation of the inactivated enzyme, exposure to 37°C induces deactivation of complex I Bos taurus

Inhibitors

EC Number Inhibitors Comment Organism Structure
7.1.1.2 Mg2+ inhibition of the enzyme in its inactive form, in its active form the enzyme complex is not sensitive Bos taurus
7.1.1.2 NEM inhibition of the enzyme in its inactive form, in its active form the enzyme complex is not sensitive Bos taurus

Localization

EC Number Localization Comment Organism GeneOntology No. Textmining
7.1.1.2 mitochondrion
-
 Bos taurus 5739
-

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Bos taurus
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 heart
-
 Bos taurus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + ubiquinone
-
 Bos taurus NAD+ + ubiquinol
-
 ?

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Bos taurus