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Literature summary extracted from

  • Smeitink, J.; Sengers, R.; Trijbels, F.; Van den Heuvel, L.
    Human NADH:ubiquinone oxidoreductase (2001), J. Bioenerg. Biomembr., 33, 259-266.
    View publication on PubMed

Application

EC Number Application Comment Organism
7.1.1.2 medicine a deficient activity of the NADH:ubiquinone oxidoreductase enzyme complex is frequently observed in clinical heterogeneous group of mitochondrial disorders with Leigh (-like) disease as the main contributor. Enzyme complex activity measurement in skeletal muscle is the mainstay of the diagnostic process. Fibroblast studies are a prerequisite whenever prenatal enzyme diagnostic is considered Homo sapiens

Organism

EC Number Organism UniProt Comment Textmining
7.1.1.2 Homo sapiens
-
-
-

Source Tissue

EC Number Source Tissue Comment Organism Textmining
7.1.1.2 chorionic villus
-
 Homo sapiens
-
7.1.1.2 muscle skeletal Homo sapiens
-
7.1.1.2 skin fibroblast cell culture Homo sapiens
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
7.1.1.2 NADH + ubiquinone
-
 Homo sapiens NAD+ + ubiquinol
-
 ?

Subunits

EC Number Subunits Comment Organism
7.1.1.2 More the enzyme complex consists of at least 43 proteins, seven are encoded by the mitochondrial genome, while the remainder are encoded by the nuclear genome Homo sapiens

Cofactor

EC Number Cofactor Comment Organism Structure
7.1.1.2 NADH
-
 Homo sapiens