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Literature summary extracted from

  • Tabor, H.; Tabor, C.W.
    Biosynthesis and metabolism of 1,4-diaminobutane, spermidine, spermine, and related amines (1972), Adv. Enzymol. Relat. Areas Mol. Biol., 36, 203-268.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
2.5.1.16 5'-methylthioadenosine W strain Escherichia coli
2.5.1.16 5'-methylthioadenosine
-
 Rattus norvegicus
2.5.1.16 spermidine W strain Escherichia coli
2.5.1.16 spermidine
-
 Neurospora crassa
2.5.1.16 spermidine
-
 Rattus norvegicus
2.5.1.16 spermidine
-
 Saccharomyces cerevisiae
2.5.1.16 sulfhydryl reagents W strain Escherichia coli

Metals/Ions

EC Number Metals/Ions Comment Organism Structure
2.5.1.16 additional information no metal ion requirement Escherichia coli
2.5.1.16 additional information no metal ion requirement Rattus norvegicus
2.5.1.16 additional information no metal ion requirement Saccharomyces cerevisiae
2.5.1.16 additional information no metal ion requirement Neurospora crassa

Molecular Weight [Da]

EC Number Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
1.5.99.6 76000
-
-
 Serratia marcescens
2.5.1.16 73000
-
-
 Rattus norvegicus
2.5.1.16 73000
-
 W strain Escherichia coli

Natural Substrates/ Products (Substrates)

EC Number Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
1.5.99.6 spermidine + cytochrome c Serratia marcescens
-
 1,3-diaminopropane + gamma-aminobutylaldehyde
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane Escherichia coli
-
 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane Rattus norvegicus
-
 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane Saccharomyces cerevisiae
-
 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane Neurospora crassa
-
 5'-methylthioadenosine + spermidine
-
 ?

Organism

EC Number Organism UniProt Comment Textmining
1.5.99.6 Serratia marcescens
-
-
-
2.5.1.16 Escherichia coli
-
 W strain
-
2.5.1.16 Neurospora crassa
-
-
-
2.5.1.16 Rattus norvegicus
-
-
-
2.5.1.16 Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

EC Number Purification (Comment) Organism
1.5.99.6
-
 Serratia marcescens
2.5.1.16
-
 Escherichia coli
2.5.1.16 partial Rattus norvegicus

Source Tissue

EC Number Source Tissue Comment Organism Textmining
2.5.1.16 brain
-
 Rattus norvegicus
-
2.5.1.16 liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.99.6 N,N'-bis(3-aminopropyl)-1,3-propanediamine + electron acceptor
-
 Serratia marcescens ? + reduced electron acceptor
-
 ?
1.5.99.6 N-(3-aminopropyl)-1,3-propanediamine + electron acceptor
-
 Serratia marcescens ? + reduced electron acceptor
-
 ?
1.5.99.6 N8-acetylspermidine + electron acceptor
-
 Serratia marcescens ? + reduced electron acceptor
-
 ?
1.5.99.6 spermidine + 2,6-dichlorophenolindophenol
-
 Serratia marcescens 1,3-diaminopropane + DELTA1-pyrroline + reduced 2,6-dichlorophenolindophenol
-
 ?
1.5.99.6 spermidine + cytochrome c
-
 Serratia marcescens 1,3-diaminopropane + gamma-aminobutylaldehyde
-
 ?
1.5.99.6 spermidine + electron acceptor
-
 Serratia marcescens 1,3-diaminopropane + DELTA1-pyrroline + reduced electron acceptor
-
 ?
1.5.99.6 spermidine + K3Fe(CN)6
-
 Serratia marcescens 1,3-diaminopropane + DELTA1-pyrroline + ferrocyanide
-
 ?
1.5.99.6 spermine + electron acceptor oxidized slowly Serratia marcescens ? + reduced electron acceptor
-
 ?
2.5.1.16 S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Escherichia coli 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Rattus norvegicus 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Saccharomyces cerevisiae 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-(5')-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Neurospora crassa 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Escherichia coli 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Rattus norvegicus 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Saccharomyces cerevisiae 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,4-diaminobutane
-
 Neurospora crassa 5'-methylthioadenosine + spermidine
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
-
 Rattus norvegicus 5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
-
 Saccharomyces cerevisiae 5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane
-
 Neurospora crassa 5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
 ?
2.5.1.16 S-adenosyl-3-methylthio-1-propylamine + 1,5-diaminopentane cadaverine Escherichia coli 5'-methylthioadenosine + N-(3-aminopropyl)-1,5-diaminopentane
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
2.5.1.16 10.3
-
 W strain Escherichia coli

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.99.6 FAD
-
 Serratia marcescens
1.5.99.6 heme
-
 Serratia marcescens
1.5.99.6 iron-protoporphyrin IX
-
 Serratia marcescens
2.5.1.16 additional information no cofactor requirement Escherichia coli
2.5.1.16 additional information no cofactor requirement Rattus norvegicus
2.5.1.16 additional information no cofactor requirement Saccharomyces cerevisiae
2.5.1.16 additional information no cofactor requirement Neurospora crassa