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Literature summary extracted from
- Cloning and mapping of the cDNA for human sarcosine dehydrogenase, a flavoenzyme defective in patients with sarcosinemia (1999), Genomics, 59, 300-308.
Application
| EC Number | Application | Comment | Organism |
|---|---|---|---|
| 1.5.8.3 | medicine | sarcosine dehydrogenase is defective in patient with sarcosinemia | Homo sapiens |
Cloned(Commentary)
| EC Number | Cloned (Comment) | Organism |
|---|---|---|
| 1.5.8.3 | - |
Homo sapiens |
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|
Molecular Weight [Da]
| EC Number | Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|---|
| 1.5.8.3 | 99505 | - |
1 * 99505 | Homo sapiens |
| 1.5.8.3 | 99510 | - |
including covalently bound FAD | Homo sapiens |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.8.3 | sarcosine + acceptor + H2O | Homo sapiens | acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate | glycine + formaldehyde + reduced acceptor | - |
? |  |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.5.8.3 | Homo sapiens | - |
- |
- |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.5.8.3 | kidney | adult and fetal | Homo sapiens | - |
| 1.5.8.3 | liver | adult and fetal | Homo sapiens | - |
| 1.5.8.3 | pancreas | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.8.3 | sarcosine + acceptor + H2O | acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate | Homo sapiens | glycine + formaldehyde + reduced acceptor | - |
? | |
Subunits
| EC Number | Subunits | Comment | Organism |
|---|---|---|---|
| 1.5.8.3 | monomer | 1 * 99505 | Homo sapiens |
Cofactor
| EC Number | Cofactor | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.5.8.3 | FAD | covalent bound FAD linked via 8a-position of the isoalloxazin ring to the imidazole N(3) of a histidine residue, structural homology between the amino acid sequence of the flavin-peptides | Homo sapiens | |
| 1.5.8.3 | tetrahydrofolate | - |
Homo sapiens | |
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Release 2023.1 (January 2023)
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