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Literature summary extracted from
- Separation and purification of sarcosine dehydrogenase and dimethylglycine dehydrogenase (1962), J. Biol. Chem., 237, 94-98.
Localization
| EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|---|
| 1.5.8.3 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
| 1.5.8.4 | mitochondrion | - |
Rattus norvegicus | 5739 | - |
Metals/Ions
| EC Number | Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|---|
| 1.5.8.3 | Fe2+ | - |
Rattus norvegicus |  |
| 1.5.8.4 | Nonheme iron | - |
Rattus norvegicus |
Natural Substrates/ Products (Substrates)
| EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.8.3 | sarcosine + acceptor + H2O | Rattus norvegicus | acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate | glycine + formaldehyde + reduced acceptor | - |
? | |
Organism
| EC Number | Organism | UniProt | Comment | Textmining |
|---|---|---|---|---|
| 1.5.8.3 | Rattus norvegicus | - |
- |
- |
| 1.5.8.4 | Rattus norvegicus | - |
- |
- |
Purification (Commentary)
| EC Number | Purification (Comment) | Organism |
|---|---|---|
| 1.5.8.3 | - |
Rattus norvegicus |
| 1.5.8.4 | using ammonium sulfate treatment and dissolution in 7.5 mM potassium phosphate | Rattus norvegicus |
Source Tissue
| EC Number | Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|---|
| 1.5.8.3 | liver | - |
Rattus norvegicus | - |
| 1.5.8.4 | liver | - |
Rattus norvegicus | - |
Specific Activity [micromol/min/mg]
| EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|---|
| 1.5.8.4 | 129 | - |
potassium phosphate fraction | Rattus norvegicus |
Substrates and Products (Substrate)
| EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|---|
| 1.5.8.3 | sarcosine + acceptor + H2O | acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate | Rattus norvegicus | glycine + formaldehyde + reduced acceptor | - |
? | |
| 1.5.8.4 | N,N-dimethylglycine + acceptor + H2O | acceptors: 2,6-dichlorophenolindophenol, phenazine methosulfate | Rattus norvegicus | sarcosine + formaldehyde + reduced acceptor | - |
? | |
pH Optimum
| EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.5.8.3 | 8 | - |
sarcosine + phenazine methosulfate | Rattus norvegicus |
| 1.5.8.4 | 8.5 | 9 | dimethylglycine + phenazine methosulfate | Rattus norvegicus |
pH Range
| EC Number | pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|---|
| 1.5.8.3 | 6 | - |
not active below, sarcosine + phenazine methosulfate | Rattus norvegicus |
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Release 2023.1 (January 2023)
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