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Literature summary extracted from

  • Moritani, M.; Tung, T.C.; Fujii, S.; Mito, H.; Izumiya, N.; Kenmochi, K.; Hirohata, R.
    Specificity of rabbit kidney demethylase (1954), J. Biol. Chem., 209, 485-492.
    View publication on PubMed

Inhibitors

EC Number Inhibitors Comment Organism Structure
1.5.3.2 additional information not inhibited by 0.01 M benzoate, 0.01 M quinine HCl, 0.01 M atabrine, 0.01 M KCN Oryctolagus cuniculus

KM Value [mM]

EC Number KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
1.5.3.2 0.262
-
 alpha-N-methyl-L-tryptophan
-
 Oryctolagus cuniculus

Organism

EC Number Organism UniProt Comment Textmining
1.5.3.2 Oryctolagus cuniculus
-
-
-

Reaction

EC Number Reaction Comment Organism Reaction ID
1.5.3.2 an N-methyl-L-amino acid + H2O + O2 = an L-amino acid + formaldehyde + H2O2 reaction mechanism Oryctolagus cuniculus
a

Source Tissue

EC Number Source Tissue Comment Organism Textmining
1.5.3.2 kidney
-
 Oryctolagus cuniculus
-

Substrates and Products (Substrate)

EC Number Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1.5.3.2 alpha-N-methyl-L-histidine + O2 + H2O
-
 Oryctolagus cuniculus L-histidine + formaldehyde + H2O2
-
 ?
1.5.3.2 alpha-N-methyl-L-tryptophan + O2 + H2O alpha-N-methyl-L-tryptophan is identical with L-abrine Oryctolagus cuniculus L-tryptophan + formaldehyde + H2O2
-
 ?
1.5.3.2 additional information more substrates, not with: N-dimethyl-L-amino acid, N-methyl-D-amino acid, L-amino acid, D-amino acid Oryctolagus cuniculus ?
-
 ?
1.5.3.2 N-methyl-L-amino acid + O2 + H2O enzyme requires the presence of a free alpha-carboxyl group in the substrate molecule, substrates with aromatic or heterocyclic substituents are more readily oxidized, followed by aliphatic N-methylamino acids with long side chain, more slowly activity towards N-methyl derivatives of beta-hydroxy-amino acids and of basic and acidic amino acids with exception of histidin, very slow demethylation of phenylsarcosine Oryctolagus cuniculus L-amino acid + formaldehyde + H2O2
-
 ?
1.5.3.2 N-methyl-L-norleucine + O2 + H2O
-
 Oryctolagus cuniculus L-norleucine + formaldehyde + H2O2
-
 ?
1.5.3.2 N-methyl-L-phenylalanine + O2 + H2O
-
 Oryctolagus cuniculus L-phenylalanine + formaldehyde + H2O2
-
 ?
1.5.3.2 N-methyl-L-tyrosine + O2 + H2O N-methyl-DL-tyrosine is identical with surinamine Oryctolagus cuniculus L-tyrosine + formaldehyde + H2O2
-
 ?
1.5.3.2 N-methyldihydroxyphenyl-DL-alanine + O2 + H2O
-
 Oryctolagus cuniculus formaldehyde + dihydroxyphenyl-DL-alanine + H2O2
-
 ?
1.5.3.2 N-methylvanillyl-L-alanine + O2 + H2O
-
 Oryctolagus cuniculus ?
-
 ?

pH Optimum

EC Number pH Optimum Minimum pH Optimum Maximum Comment Organism
1.5.3.2 7.2
-
 assay at Oryctolagus cuniculus

Cofactor

EC Number Cofactor Comment Organism Structure
1.5.3.2 FAD as prosthetic group Oryctolagus cuniculus