EC Number | Application | Comment | Organism |
---|---|---|---|
1.5.1.8 | medicine | hyperlysinemia | Homo sapiens |
EC Number | Inhibitors | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.8 | (NH4)2SO4 | 1 mM, 71% inhibition | Homo sapiens |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH | Homo sapiens | lysine catabolism | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.8 | Homo sapiens | - |
- |
- |
EC Number | Purification (Comment) | Organism |
---|---|---|
1.5.1.8 | 9.6fold partial purification from liver | Homo sapiens |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.5.1.8 | adrenal gland | low enzyme concentration | Homo sapiens | - |
1.5.1.8 | brain | low enzyme concentration | Homo sapiens | - |
1.5.1.8 | heart | high enzyme concentration | Homo sapiens | - |
1.5.1.8 | kidney | after liver next highest enzyme concentration | Homo sapiens | - |
1.5.1.8 | liver | highest enzyme concentration | Homo sapiens | - |
1.5.1.8 | additional information | trace enzyme activity in lung, spleen, and striated muscle, no activity in pancreas, thymus, peripheral leucocyte or erythrocyte | Homo sapiens | - |
1.5.1.8 | skin | low enzyme concentration | Homo sapiens | - |
1.5.1.8 | thyroid gland | low enzyme concentration | Homo sapiens | - |
EC Number | Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|---|
1.5.1.8 | additional information | - |
- |
Homo sapiens |
EC Number | Storage Stability | Organism |
---|---|---|
1.5.1.8 | -25°C, 1 month, stable | Homo sapiens |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH | very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH | Homo sapiens | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | epsilon-N-(L-glutaryl-2)-L-lysine is identical with saccharopine | ? | |
1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH | very strict substrate specificity for L-lysine, 2-oxoglutarate and NADPH | Homo sapiens | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine | ? | |
1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH | enzyme catalyzes lysine degradation to saccharopine | Homo sapiens | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | epsilon-N-(L-glutaryl-2)-L-lysine is identical with saccharopine | ? | |
1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH | enzyme catalyzes lysine degradation to saccharopine | Homo sapiens | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | N6-(L-1,3-dicarboxypropyl)-L-lysine is identical with saccharopine | ? | |
1.5.1.8 | L-lysine + 2-oxoglutarate + NADPH | lysine catabolism | Homo sapiens | N6-(L-1,3-dicarboxypropyl)-L-lysine + NADP+ + H2O | - |
? |
EC Number | pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|---|
1.5.1.8 | 6.7 | 7 | - |
Homo sapiens |
EC Number | pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|---|
1.5.1.8 | 6.2 | 8.6 | pH 6.2: about 50% of activity maximum, pH 8.6: about 60% of activity maximum | Homo sapiens |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.8 | additional information | NADH can not replace NADPH | Homo sapiens | |
1.5.1.8 | NADPH | specific for NADPH | Homo sapiens |