EC Number | Application | Comment | Organism |
---|---|---|---|
1.5.1.6 | medicine | formic acidemia: toxicity of methanol in humans is correlated with formate accumulation as a result of low rates of formate oxidation, which is in vivo dependent on enzyme activity and on hepatic tetrahydrofolate levels | Homo sapiens |
1.5.1.6 | medicine | methanol-induced toxicity in Müller cells of the retina, role of 10-FDH in formate intoxination both as a protectant and as a toxicity-provoking element | Homo sapiens |
EC Number | Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|---|
1.5.1.6 | cytosol | comparable amounts of cytosolic and mitochondrial FDH in retinal tissues | Homo sapiens | 5829 | - |
1.5.1.6 | cytosol | comparable amounts of cytosolic and mitochondrial FDH in retinal tissues | Rattus norvegicus | 5829 | - |
1.5.1.6 | mitochondrion | comparable amounts of cytosolic and mitochondrial FDH in retinal tissues | Homo sapiens | 5739 | - |
1.5.1.6 | mitochondrion | comparable amounts of cytosolic and mitochondrial FDH in retinal tissues | Rattus norvegicus | 5739 | - |
EC Number | Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | Homo sapiens | folate-dependent metabolism of formate to carbon dioxide | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | Rattus norvegicus | folate-dependent metabolism of formate to carbon dioxide | tetrahydrofolate + CO2 + NADPH + H+ | - |
? |
EC Number | Organism | UniProt | Comment | Textmining |
---|---|---|---|---|
1.5.1.6 | Homo sapiens | - |
- |
- |
1.5.1.6 | Rattus norvegicus | - |
Sprague-Dawley rats | - |
EC Number | Source Tissue | Comment | Organism | Textmining |
---|---|---|---|---|
1.5.1.6 | liver | - |
Homo sapiens | - |
1.5.1.6 | liver | - |
Rattus norvegicus | - |
1.5.1.6 | retina | much lower levels than in liver, preferentially localized in Müller cells, FDH levels in human retina are higher than in rat retina, folate levels in human retina are 14% of those in rat retina | Homo sapiens | - |
1.5.1.6 | retina | much lower levels than in liver, preferentially localized in Müller cells, FDH levels in human retina are higher than in rat retina, folate levels in human retina are 14% of those in rat retina | Rattus norvegicus | - |
EC Number | Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|---|
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | - |
Homo sapiens | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | - |
Rattus norvegicus | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | folate-dependent metabolism of formate to carbon dioxide | Homo sapiens | tetrahydrofolate + CO2 + NADPH + H+ | - |
? | |
1.5.1.6 | 10-formyltetrahydrofolate + NADP+ + H2O | folate-dependent metabolism of formate to carbon dioxide | Rattus norvegicus | tetrahydrofolate + CO2 + NADPH + H+ | - |
? |
EC Number | Cofactor | Comment | Organism | Structure |
---|---|---|---|---|
1.5.1.6 | 10-formyltetrahydrofolate | 10-formyltetrahydrofolate | Homo sapiens | |
1.5.1.6 | 10-formyltetrahydrofolate | 10-formyltetrahydrofolate | Rattus norvegicus | |
1.5.1.6 | tetrahydrofolate | - |
Homo sapiens | |
1.5.1.6 | tetrahydrofolate | - |
Rattus norvegicus |